Abstract:
:The human helicase senataxin (SETX) has been linked to the neurodegenerative diseases amyotrophic lateral sclerosis (ALS4) and ataxia with oculomotor apraxia (AOA2). Here we identified a role for SETX in controlling the antiviral response. Cells that had undergone depletion of SETX and SETX-deficient cells derived from patients with AOA2 had higher expression of antiviral mediators in response to infection than did wild-type cells. Mechanistically, we propose a model whereby SETX attenuates the activity of RNA polymerase II (RNAPII) at genes stimulated after a virus is sensed and thus controls the magnitude of the host response to pathogens and the biogenesis of various RNA viruses (e.g., influenza A virus and West Nile virus). Our data indicate a potentially causal link among inborn errors in SETX, susceptibility to infection and the development of neurologic disorders.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Miller MS,Rialdi A,Ho JS,Tilove M,Martinez-Gil L,Moshkina NP,Peralta Z,Noel J,Melegari C,Maestre AM,Mitsopoulos P,Madrenas J,Heinz S,Benner C,Young JA,Feagins AR,Basler CF,Fernandez-Sesma A,Becherel OJ,Lavin MF,vadoi
10.1038/ni.3132subject
Has Abstractpub_date
2015-05-01 00:00:00pages
485-94issue
5eissn
1529-2908issn
1529-2916pii
ni.3132journal_volume
16pub_type
杂志文章abstract::Allergic inflammation has crucial roles in allergic diseases such as asthma. It is therefore important to understand why and how the immune system responds to allergens. Here we found that full-length interleukin 33 (IL-33FL), an alarmin cytokine with critical roles in type 2 immunity and asthma, functioned as a prote...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-018-0067-5
更新日期:2018-04-01 00:00:00
abstract::The activation of dendritic cells (DC) to produce interleukin 12 (IL-12) is thought to be a key step in the initiation of cell-mediated immunity to intracellular pathogens. Here we show that ligation of the C-C chemokine receptor (CCR) 5 can provide a major signal for the induction of IL-12 synthesis by the CD8 alpha+...
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abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature immunology
pub_type: 已发布勘误
doi:10.1038/s41590-020-0739-9
更新日期:2020-08-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/76877
更新日期:2000-07-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1670
更新日期:2008-12-01 00:00:00
abstract::The molecular mechanisms directing the development of 'natural' CD4+CD25+Foxp3+ regulatory T cells (T(reg) cells) in the thymus are not thoroughly understood. We show here that conditional deletion of transforming growth factor-beta receptor I (TbetaRI) in T cells blocked the appearance of CD4+CD25+Foxp3+ thymocytes a...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1607
更新日期:2008-06-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3470
更新日期:2016-07-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni.3691
更新日期:2017-03-22 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2154
更新日期:2011-11-13 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/79767
更新日期:2000-09-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni.2491
更新日期:2013-01-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1020
更新日期:2004-01-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1304
更新日期:2006-03-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-018-0110-6
更新日期:2018-06-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni790
更新日期:2002-05-01 00:00:00
abstract::Respiratory infections are common precursors to asthma exacerbations in children, but molecular immune responses that determine whether and how an infection causes an exacerbation are poorly understood. By using systems-scale network analysis, we identify repertoires of cellular transcriptional pathways that lead to a...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-019-0347-8
更新日期:2019-05-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni.1894
更新日期:2010-08-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1267
更新日期:2005-12-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni810
更新日期:2002-07-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3412
更新日期:2016-06-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2018-12-01 00:00:00
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更新日期:2019-12-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1085
更新日期:2004-07-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature immunology
pub_type: 已发布勘误
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更新日期:2020-01-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2918
更新日期:2014-07-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3667
更新日期:2017-03-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/87766
更新日期:2001-05-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
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更新日期:2020-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-03-01 00:00:00