Abstract:
:A fundamental puzzle in immunology is how the immune system decides what types of immune responses to launch against different stimuli. Although much is known about control of T helper type 1 (T(H)1) and T(H)17 responses, the mechanisms that initiate T(H)2 and T regulatory (T(reg)) responses remain obscure. Emerging studies suggest a fundamental role for the innate immune system, particularly dendritic cells (DCs), in this process. We review these studies, and suggest that the innate control of T(H)2 and T(reg) responses can be viewed as different hierarchies of organization, in which DCs, their innate receptors and signaling networks, and their interactions with other cells and local microenvironments represent different levels of the hierarchy.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Pulendran B,Tang H,Manicassamy Sdoi
10.1038/ni.1894subject
Has Abstractpub_date
2010-08-01 00:00:00pages
647-55issue
8eissn
1529-2908issn
1529-2916pii
ni.1894journal_volume
11pub_type
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