Abstract:
:Autophagosomes delivers cytoplasmic constituents to lysosomes for degradation, whereas inflammasomes are molecular platforms activated by infection or stress that regulate the activity of caspase-1 and the maturation of interleukin 1β (IL-1β) and IL-18. Here we show that the induction of AIM2 or NLRP3 inflammasomes in macrophages triggered activation of the G protein RalB and autophagosome formation. The induction of autophagy did not depend on the adaptor ASC or capase-1 but was dependent on the presence of the inflammasome sensor. Blocking autophagy potentiated inflammasome activity, whereas stimulating autophagy limited it. Assembled inflammasomes underwent ubiquitination and recruited the autophagic adaptor p62, which assisted their delivery to autophagosomes. Our data indicate that autophagy accompanies inflammasome activation to temper inflammation by eliminating active inflammasomes.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Shi CS,Shenderov K,Huang NN,Kabat J,Abu-Asab M,Fitzgerald KA,Sher A,Kehrl JHdoi
10.1038/ni.2215subject
Has Abstractpub_date
2012-01-29 00:00:00pages
255-63issue
3eissn
1529-2908issn
1529-2916pii
ni.2215journal_volume
13pub_type
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journal_title:Nature immunology
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pub_type: 已发布勘误
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更新日期:2014-11-01 00:00:00
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更新日期:2004-01-01 00:00:00
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更新日期:2001-11-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni1410
更新日期:2006-12-01 00:00:00
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journal_title:Nature immunology
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doi:10.1038/ni1123
更新日期:2004-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1038/ni1053
更新日期:2004-04-01 00:00:00
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更新日期:2006-07-01 00:00:00
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更新日期:2003-09-01 00:00:00
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更新日期:2004-07-01 00:00:00
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更新日期:2002-11-01 00:00:00
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更新日期:2003-01-01 00:00:00
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