Abstract:
:The activation of an immune response requires recognition of microorganisms by host receptors. In drosophila, detection of Gram-positive bacteria is mediated by cooperation between the peptidoglycan-recognition protein-SA (PGRP-SA) and Gram-negative binding protein 1 (GNBP1) proteins. Here we show that some Gram-positive bacterial species activate an immune response in a PGRP-SA- and GNBP1-independent manner, indicating that alternative receptors exist. Consistent with this, we noted that PGRP-SD mutants were susceptible to some Gram-positive bacteria and that a loss-of-function mutation in PGRP-SD severely exacerbated the PGRP-SA and GNBP1 mutant phenotypes. These data indicate that PGRP-SD can function as a receptor for Gram-positive bacteria and shows partial redundancy with the PGRP-SA-GNBP1 complex.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Bischoff V,Vignal C,Boneca IG,Michel T,Hoffmann JA,Royet Jdoi
10.1038/ni1123keywords:
subject
Has Abstractpub_date
2004-11-01 00:00:00pages
1175-80issue
11eissn
1529-2908issn
1529-2916pii
ni1123journal_volume
5pub_type
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