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Memory and flexibility of cytokine gene expression as separable properties of human T(H)1 and T(H)2 lymphocytes.

Abstract：

:CD4+ T cell priming under T helper type I (T(H)1) or T(H)2 conditions gives rise to polarized cytokine gene expression. We found that in these conditions human naive T cells acquired stable histone hyperacetylation at either the Ifng or Il4 promoter. Effector memory T cells showed polarized cytokine gene acetylation patterns in vivo, whereas central memory T cells had hypoacetylated cytokine genes but acquired polarized acetylation and expression after appropriate stimulation. However, hypoacetylation of the nonexpressed cytokine gene did not lead to irreversible silencing because most T(H)1 and T(H)2 cells acetylated and expressed the alternative gene when stimulated under opposite T(H) conditions. Such cytokine flexibility was absent in a subset of T(H)2 cells that failed to up-regulate T-bet and to express interferon-gamma when stimulated under T(H)1 conditions. Thus, most human CD4+ T cells retain both memory and flexibility of cytokine gene expression.

journal_name

Nat Immunol

journal_title

Nature immunology

authors

Messi M,Giacchetto I,Nagata K,Lanzavecchia A,Natoli G,Sallusto F

doi

10.1038/ni872

keywords:

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

78-86

issue

1

eissn

1529-2908

issn

1529-2916

pii

ni872

journal_volume

4

pub_type

杂志文章

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