USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation.

abstract：:The autoimmune regulator Aire is expressed in a small proportion of medullary thymic epithelial cells (mTECs) and is crucial in the induction of central T cell tolerance. The origin and development of Aire(+) mTECs, however, are not well understood. Here we demonstrate that the tight-junction components claudin-3 and ...

journal_title：Nature immunology

authors： Hamazaki Y,Fujita H,Kobayashi T,Choi Y,Scott HS,Matsumoto M,Minato N

更新日期：2007-03-01 00:00:00

abstract：:Regulatory T (Treg) cells respond to immune and inflammatory signals to mediate immunosuppression, but how the functional integrity of Treg cells is maintained under activating environments is unclear. Here we show that autophagy is active in Treg cells and supports their lineage stability and survival fitness. Treg c...

journal_title：Nature immunology

authors： Wei J,Long L,Yang K,Guy C,Shrestha S,Chen Z,Wu C,Vogel P,Neale G,Green DR,Chi H

更新日期：2016-03-01 00:00:00

abstract：:Evidence suggests that regulatory T cells expressing the transcription factor Foxp3 develop extrathymically and intrathymically. Mechanisms of extrathymic induction require further scrutiny, especially as proliferation and/or phenotypic changes of preexisting suppressor cells must be distinguished from true de novo ge...

journal_title：Nature immunology

authors： Kretschmer K,Apostolou I,Hawiger D,Khazaie K,Nussenzweig MC,von Boehmer H

更新日期：2005-12-01 00:00:00

abstract：:EAE can refer either to experimental autoimmune encephalomyelitis or experimental allergic encephalomyelitis. Although EAE is classically a prototypic T helper 1 (TH1) cell-mediated autoimmune disease, it can also be induced by TH2 cells. Characteristically, the most severe manifestation of allergy, anaphylaxis, is as...

journal_title：Nature immunology

authors： Pedotti R,Mitchell D,Wedemeyer J,Karpuj M,Chabas D,Hattab EM,Tsai M,Galli SJ,Steinman L

更新日期：2001-03-01 00:00:00

abstract：:Beyond its well-characterized functions in antibody diversification, the cytidine deaminase AID can catalyze off-target DNA damage and has been hypothesized to edit RNA and mediate DNA demethylation. To comprehensively examine the effects of AID on the transcriptome and the pattern of DNA methylation ('methylome'), we...

journal_title：Nature immunology

authors： Fritz EL,Rosenberg BR,Lay K,Mihailović A,Tuschl T,Papavasiliou FN

更新日期：2013-07-01 00:00:00

abstract：:Deficiency in mevalonate kinase (MVK) causes systemic inflammation. However, the molecular mechanisms linking the mevalonate pathway to inflammation remain obscure. Geranylgeranyl pyrophosphate, a non-sterol intermediate of the mevalonate pathway, is the substrate for protein geranylgeranylation, a protein post-transl...

journal_title：Nature immunology

authors： Akula MK,Shi M,Jiang Z,Foster CE,Miao D,Li AS,Zhang X,Gavin RM,Forde SD,Germain G,Carpenter S,Rosadini CV,Gritsman K,Chae JJ,Hampton R,Silverman N,Gravallese EM,Kagan JC,Fitzgerald KA,Kastner DL,Golenbock DT,Ber

更新日期：2016-08-01 00:00:00

abstract：:CD25(+)CD4(+) regulatory T cells in normal animals are engaged in the maintenance of immunological self-tolerance. We show here that glucocorticoid-induced tumor necrosis factor receptor family-related gene (GITR, also known as TNFRSF18)--a member of the tumor necrosis factor-nerve growth factor (TNF-NGF) receptor gen...

journal_title：Nature immunology

authors： Shimizu J,Yamazaki S,Takahashi T,Ishida Y,Sakaguchi S

更新日期：2002-02-01 00:00:00

abstract：:Regulated glycosylation controls T cell processes, including activation, differentiation and homing by creating or masking ligands for endogenous lectins. Here we show that stimuli promoting T helper type 1 (TH1), TH2 or interleukin 17-producing T helper (TH-17) differentiation can differentially regulate the glycosyl...

journal_title：Nature immunology

authors： Toscano MA,Bianco GA,Ilarregui JM,Croci DO,Correale J,Hernandez JD,Zwirner NW,Poirier F,Riley EM,Baum LG,Rabinovich GA

更新日期：2007-08-01 00:00:00

abstract：:CD4(+) T cells producing interleukin 17 (IL-17) are associated with autoimmunity, although the precise mechanisms that control their development are undefined. Here we present data that challenge the idea of a shared developmental pathway with T helper type 1 (T(H)1) or T(H)2 lineages and instead favor the idea of a d...

journal_title：Nature immunology

authors： Harrington LE,Hatton RD,Mangan PR,Turner H,Murphy TL,Murphy KM,Weaver CT

更新日期：2005-11-01 00:00:00

abstract：:Plasma cells are cellular factories devoted entirely to the manufacture and export of a single product: soluble immunoglobulin (Ig). As the final mediators of a humoral response, plasma cells play a critical role in adaptive immunity. Although intense effort has been devoted to studying the regulation and requirements...

journal_title：Nature immunology

authors： Calame KL

更新日期：2001-12-01 00:00:00

abstract：:The variable lymphocyte receptors (VLRs) of jawless vertebrates such as lamprey and hagfish are composed of highly diverse modular leucine-rich repeats. Each lymphocyte assembles a unique VLR by rearrangement of the germline gene. In the lamprey genome, we identify here about 850 distinct cassettes encoding leucine-ri...

journal_title：Nature immunology

authors： Rogozin IB,Iyer LM,Liang L,Glazko GV,Liston VG,Pavlov YI,Aravind L,Pancer Z

更新日期：2007-06-01 00:00:00

abstract：:Although master transcription factors (TFs) are key to the development of specific T cell subsets, whether additional transcriptional regulators are induced by the same stimuli that dominantly repress the development of other, non-specific T cell lineages has not been fully elucidated. Through the use of regulatory T ...

journal_title：Nature immunology

authors： Wu C,Chen Z,Dardalhon V,Xiao S,Thalhamer T,Liao M,Madi A,Franca RF,Han T,Oukka M,Kuchroo V

更新日期：2017-03-01 00:00:00

abstract：:DAP12 is a signaling adaptor containing an immunoreceptor tyrosine-based activation motif (ITAM) that pairs with receptors on myeloid cells and natural killer cells. We examine here the responses of mice lacking DAP12 to stimulation through Toll-like receptors (TLRs). Unexpectedly, DAP12-deficient macrophages produced...

journal_title：Nature immunology

authors： Hamerman JA,Tchao NK,Lowell CA,Lanier LL

更新日期：2005-06-01 00:00:00

abstract：:Chronic inflammation is a common feature of obesity, with elevated cytokines such as interleukin-1 (IL-1) in the circulation and tissues. Here, we report an unconventional IL-1R-MyD88-IRAK2-PHB/OPA1 signaling axis that reprograms mitochondrial metabolism in adipocytes to exacerbate obesity. IL-1 induced recruitment of...

journal_title：Nature immunology

authors： Zhou H,Wang H,Yu M,Schugar RC,Qian W,Tang F,Liu W,Yang H,McDowell RE,Zhao J,Gao J,Dongre A,Carman JA,Yin M,Drazba JA,Dent R,Hine C,Chen YR,Smith JD,Fox PL,Brown JM,Li X

更新日期：2020-10-01 00:00:00

abstract：:Although the relationship between hematopoietic stem cells and progenitor populations has been investigated extensively under steady-state conditions, the dynamic response of the hematopoietic compartment during acute infection is largely unknown. Here we show that after infection of mice with Plasmodium chabaudi, a c...

journal_title：Nature immunology

authors： Belyaev NN,Brown DE,Diaz AI,Rae A,Jarra W,Thompson J,Langhorne J,Potocnik AJ

更新日期：2010-06-01 00:00:00

abstract：:CD8+ T cells responding to chronic infections or tumors acquire an 'exhausted' state associated with elevated expression of inhibitory receptors, including PD-1, and impaired cytokine production. Exhausted T cells are continuously replenished by T cells with precursor characteristics that self-renew and depend on the ...

journal_title：Nature immunology

authors： Utzschneider DT,Gabriel SS,Chisanga D,Gloury R,Gubser PM,Vasanthakumar A,Shi W,Kallies A

更新日期：2020-10-01 00:00:00

abstract：:Upregulation of the inducible gene products MICA (human) and Rae-1 (mouse) may promote tumor surveillance and autoimmunity by engaging the activating receptor NKG2D on natural killer (NK) cells and T cells. Nevertheless, sustained expression of MICA by tumors can also elicit NKG2D downregulation, perhaps indicating 'i...

journal_title：Nature immunology

authors： Oppenheim DE,Roberts SJ,Clarke SL,Filler R,Lewis JM,Tigelaar RE,Girardi M,Hayday AC

更新日期：2005-09-01 00:00:00

abstract：:Group 2 innate lymphoid cells (ILC2s) and CD4+ type 2 helper T cells (TH2 cells) are defined by their similar effector cytokines, which together mediate the features of allergic immunity. We found that tissue ILC2s and TH2 cells differentiated independently but shared overlapping effector function programs that were m...

journal_title：Nature immunology

authors： Van Dyken SJ,Nussbaum JC,Lee J,Molofsky AB,Liang HE,Pollack JL,Gate RE,Haliburton GE,Ye CJ,Marson A,Erle DJ,Locksley RM

更新日期：2016-12-01 00:00:00

abstract：:Hematopoiesis requires tight regulation of the hematopoietic stem cell (HSC) population; however, the dynamics of HSC use at steady state are uncertain. Over 3-7 months, we evaluated the repopulation and self-renewal of more than 600 individual human 'severe combined immunodeficiency mouse-repopulating cells' (SRCs), ...

journal_title：Nature immunology

authors： McKenzie JL,Gan OI,Doedens M,Wang JC,Dick JE

更新日期：2006-11-01 00:00:00

abstract：:Hematopoietic stem and progenitor cells (HSPCs) are regulated by various bone marrow stromal cell types. Here we identified rare activated bone marrow monocytes and macrophages with high expression of α-smooth muscle actin (α-SMA) and the cyclooxygenase COX-2 that were adjacent to primitive HSPCs. These myeloid cells ...

journal_title：Nature immunology

authors： Ludin A,Itkin T,Gur-Cohen S,Mildner A,Shezen E,Golan K,Kollet O,Kalinkovich A,Porat Z,D'Uva G,Schajnovitz A,Voronov E,Brenner DA,Apte RN,Jung S,Lapidot T

更新日期：2012-11-01 00:00:00

abstract：:CD8(+) T cells eliminate intracellular infections through two contact-dependent effector functions: cytolysis and secretion of antiviral cytokines. Here we identify the following additional function for memory CD8(+) T cells that persist at front-line sites of microbial exposure: to serve as local sensors of previousl...

journal_title：Nature immunology

authors： Schenkel JM,Fraser KA,Vezys V,Masopust D

更新日期：2013-05-01 00:00:00

abstract：:Interleukin 1β (IL-1β) is an important inflammatory mediator of type 2 diabetes. Here we show that oligomers of islet amyloid polypeptide (IAPP), a protein that forms amyloid deposits in the pancreas during type 2 diabetes, triggered the NLRP3 inflammasome and generated mature IL-1β. One therapy for type 2 diabetes, g...

journal_title：Nature immunology

authors： Masters SL,Dunne A,Subramanian SL,Hull RL,Tannahill GM,Sharp FA,Becker C,Franchi L,Yoshihara E,Chen Z,Mullooly N,Mielke LA,Harris J,Coll RC,Mills KH,Mok KH,Newsholme P,Nuñez G,Yodoi J,Kahn SE,Lavelle EC,O'Neill

更新日期：2010-10-01 00:00:00

abstract：:CARMA1 is a lymphocyte-specific member of the membrane-associated guanylate kinase (MAGUK) family of scaffolding proteins, which coordinate signaling pathways emanating from the plasma membrane. CARMA1 interacts with Bcl10 via its caspase-recruitment domain (CARD). Here we investigated the role of CARMA1 in T cell act...

journal_title：Nature immunology

authors： Gaide O,Favier B,Legler DF,Bonnet D,Brissoni B,Valitutti S,Bron C,Tschopp J,Thome M

更新日期：2002-09-01 00:00:00

abstract：:The detection of aberrant cells by natural killer (NK) cells is controlled by the integration of signals from activating and inhibitory ligands and from cytokines such as IL-15. We identified cytokine-inducible SH2-containing protein (CIS, encoded by Cish) as a critical negative regulator of IL-15 signaling in NK cell...

journal_title：Nature immunology

authors： Delconte RB,Kolesnik TB,Dagley LF,Rautela J,Shi W,Putz EM,Stannard K,Zhang JG,Teh C,Firth M,Ushiki T,Andoniou CE,Degli-Esposti MA,Sharp PP,Sanvitale CE,Infusini G,Liau NP,Linossi EM,Burns CJ,Carotta S,Gray DH,Se

更新日期：2016-07-01 00:00:00

abstract：:We describe a protein with the hallmarks of a chemokine, designated CXCL16, that is made by dendritic cells (DCs) in lymphoid organ T cell zones and by cells in the splenic red pulp. CXCL16 contains a transmembrane domain and both membrane-bound and soluble forms are produced. Naïve CD8 T cells, natural killer T cells...

journal_title：Nature immunology

authors： Matloubian M,David A,Engel S,Ryan JE,Cyster JG

更新日期：2000-10-01 00:00:00

abstract：:Rearrangement of immunoglobulin heavy-chain variable (V(H)) gene segments has been suggested to be regulated by interleukin 7 signaling in pro-B cells. However, the genetic evidence for this recombination pathway has been challenged. Furthermore, no molecular components that directly control V(H) gene rearrangement ha...

journal_title：Nature immunology

authors： Bertolino E,Reddy K,Medina KL,Parganas E,Ihle J,Singh H

更新日期：2005-08-01 00:00:00

abstract：:T cell homeostasis is crucial for a functional immune system, as the accumulation of T cells resulting from lack of regulatory T cells or an inability to shut down immune responses can lead to inflammation and autoimmune pathology. Here we show that Blimp-1, a transcriptional repressor that is a 'master regulator' of ...

journal_title：Nature immunology

authors： Kallies A,Hawkins ED,Belz GT,Metcalf D,Hommel M,Corcoran LM,Hodgkin PD,Nutt SL

更新日期：2006-05-01 00:00:00

abstract：:Vaccines can have nonspecific effects through their modulation of responses to infections not specifically targeted by the vaccine. However, lack of knowledge about the underlying immunological mechanisms and molecular cause-and-effect relationships prevent use of this potentially powerful early-life intervention to i...

journal_title：Nature immunology

authors： Aaby P,Kollmann TR,Benn CS

更新日期：2014-10-01 00:00:00

abstract：:The Fc receptor common gamma-chain (FcRgamma) is a widely expressed adaptor bearing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. We show here that basophils lacking FcRgamma developed normally and proliferated efficiently in response to inter...

journal_title：Nature immunology

authors： Hida S,Yamasaki S,Sakamoto Y,Takamoto M,Obata K,Takai T,Karasuyama H,Sugane K,Saito T,Taki S

更新日期：2009-02-01 00:00:00

abstract：:The maintenance of immunological tolerance requires the deletion of self-reactive T cells in the thymus. The expression of genes encoding tissue-specific antigens (TSAs) by thymic epithelial cells is critical for this process and depends on activity of the transcriptional regulator Aire; however, the molecular mechani...

journal_title：Nature immunology

authors： Waterfield M,Khan IS,Cortez JT,Fan U,Metzger T,Greer A,Fasano K,Martinez-Llordella M,Pollack JL,Erle DJ,Su M,Anderson MS

更新日期：2014-03-01 00:00:00