Abstract:
:Hematopoietic stem and progenitor cells (HSPCs) are regulated by various bone marrow stromal cell types. Here we identified rare activated bone marrow monocytes and macrophages with high expression of α-smooth muscle actin (α-SMA) and the cyclooxygenase COX-2 that were adjacent to primitive HSPCs. These myeloid cells resisted radiation-induced cell death and further upregulated COX-2 expression under stress conditions. COX-2-derived prostaglandin E(2) (PGE(2)) prevented HSPC exhaustion by limiting the production of reactive oxygen species (ROS) via inhibition of the kinase Akt and higher stromal-cell expression of the chemokine CXCL12, which is essential for stem-cell quiescence. Our study identifies a previously unknown subset of α-SMA(+) activated monocytes and macrophages that maintain HSPCs and protect them from exhaustion during alarm situations.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Ludin A,Itkin T,Gur-Cohen S,Mildner A,Shezen E,Golan K,Kollet O,Kalinkovich A,Porat Z,D'Uva G,Schajnovitz A,Voronov E,Brenner DA,Apte RN,Jung S,Lapidot Tdoi
10.1038/ni.2408subject
Has Abstractpub_date
2012-11-01 00:00:00pages
1072-82issue
11eissn
1529-2908issn
1529-2916pii
ni.2408journal_volume
13pub_type
杂志文章abstract::We used high-resolution mass spectrometry to map the cytotoxic T lymphocyte (CTL) proteome and the effect of the metabolic checkpoint kinase mTORC1 on CTLs. The CTL proteome was dominated by metabolic regulators and granzymes, and mTORC1 selectively repressed and promoted expression of a subset of CTL proteins (~10%)....
journal_title:Nature immunology
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
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更新日期:2007-03-01 00:00:00
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journal_title:Nature immunology
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更新日期:2002-05-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Nature immunology
pub_type: 杂志文章
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journal_title:Nature immunology
pub_type: 杂志文章
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更新日期:2014-06-01 00:00:00
abstract::The balance of myeloid populations and lymphoid populations must be well controlled. Here we found that osteopontin (OPN) skewed this balance during pathogenic conditions such as infection and autoimmunity. Notably, two isoforms of OPN exerted distinct effects in shifting this balance through cell-type-specific regula...
journal_title:Nature immunology
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更新日期:2017-09-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni1410
更新日期:2006-12-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3200
更新日期:2015-07-01 00:00:00
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doi:10.1038/ni955
更新日期:2003-08-01 00:00:00
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更新日期:2016-12-01 00:00:00
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pub_type: 已发布勘误
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更新日期:2019-12-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-019-0542-7
更新日期:2019-12-01 00:00:00
abstract::In the version of this article initially published, the label (CASP4-C285A-HA) above the second and fifth lanes in the right blot in Fig. 1e is incorrect; the correct label is CASP4-C258A-HA. Also, the two labels at right above the plot in Fig. 6c were switched; the far right label should be 'Co-housed Serpinb1a-/-' (...
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pub_type: 杂志文章
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更新日期:2004-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-06-01 00:00:00
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更新日期:2014-11-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1139
更新日期:2004-12-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
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更新日期:2005-02-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
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更新日期:2007-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-08-01 00:00:00