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Inducible degradation of lncRNA Sros1 promotes IFN-γ-mediated activation of innate immune responses by stabilizing Stat1 mRNA.

Abstract：

:Interferon-γ (IFN-γ) is essential for the innate immune response to intracellular bacteria. Noncoding RNAs and RNA-binding proteins (RBPs) need to be further considered in studies of regulation of the IFN-γ-activated signaling pathway in macrophages. In the present study, we found that the microRNA miR-1 promoted IFN-γ-mediated clearance of Listeria monocytogenes in macrophages by indirectly stabilizing the Stat1 messenger RNA through the degradation of the cytoplasmic long noncoding RNA Sros1. Inducible degradation or genetic loss of Sros1 led to enhanced IFN-γ-dependent activation of the innate immune response. Mechanistically, Sros1 blocked the binding of Stat1 mRNA to the RBP CAPRIN1, which stabilized the Stat1 mRNA and, consequently, promoted IFN-γ-STAT1-mediated innate immunity. These observations shed light on the complex RNA-RNA regulatory networks involved in cytokine-initiated innate responses in host-pathogen interactions.

journal_name

Nat Immunol

journal_title

Nature immunology

authors

Xu H,Jiang Y,Xu X,Su X,Liu Y,Ma Y,Zhao Y,Shen Z,Huang B,Cao X

doi

10.1038/s41590-019-0542-7

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

1621-1630

issue

12

eissn

1529-2908

issn

1529-2916

pii

10.1038/s41590-019-0542-7

journal_volume

20

pub_type

杂志文章

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