Abstract:
:Macrophages have protective roles in immunity to pathogens, tissue development, homeostasis and repair following damage. Maladaptive immunity and inflammation provoke changes in macrophage function that are causative of disease. Despite a historical wealth of knowledge about macrophages, recent advances have revealed unknown aspects of their development and function. Following development, macrophages are activated by diverse signals. Such tissue microenvironmental signals together with epigenetic changes influence macrophage development, activation and functional diversity, with consequences in disease and homeostasis. We discuss here how recent discoveries in these areas have led to a multidimensional concept of macrophage ontogeny, activation and function. In connection with this, we also discuss how technical advances facilitate a new roadmap for the isolation and analysis of macrophages at high resolution.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Ginhoux F,Schultze JL,Murray PJ,Ochando J,Biswas SKdoi
10.1038/ni.3324subject
Has Abstractpub_date
2016-01-01 00:00:00pages
34-40issue
1eissn
1529-2908issn
1529-2916pii
ni.3324journal_volume
17pub_type
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