Innate-like functions of natural killer T cell subsets result from highly divergent gene programs.

abstract：:Innate lymphoid cells (ILCs) of the ILC22 type protect the intestinal mucosa from infection by secreting interleukin 22 (IL-22). ILC22 cells include NKp46(+) and lymphoid tissue-inducer (LTi)-like subsets that express the aryl hydrocarbon receptor (AHR). Here we found that Ahr(-/-) mice had a considerable deficit in I...

journal_title：Nature immunology

authors： Lee JS,Cella M,McDonald KG,Garlanda C,Kennedy GD,Nukaya M,Mantovani A,Kopan R,Bradfield CA,Newberry RD,Colonna M

更新日期：2011-11-20 00:00:00

abstract：:The molecular mechanisms underlying the differentiation of interleukin 17-producing T helper cells (T(H)-17 cells) are still poorly understood. Here we show that optimal transcription of the gene encoding interleukin 17 (Il17) required a 2-kilobase promoter and at least one conserved noncoding (enhancer) sequence, CNS...

journal_title：Nature immunology

authors： Zhang F,Meng G,Strober W

更新日期：2008-11-01 00:00:00

abstract：:B cells are activated by two temporally distinct signals, the first provided by the binding of antigen to the B cell antigen receptor (BCR), and the second provided by helper T cells. Here we found that B cells responded to antigen by rapidly increasing their metabolic activity, including both oxidative phosphorylatio...

journal_title：Nature immunology

authors： Akkaya M,Traba J,Roesler AS,Miozzo P,Akkaya B,Theall BP,Sohn H,Pena M,Smelkinson M,Kabat J,Dahlstrom E,Dorward DW,Skinner J,Sack MN,Pierce SK

更新日期：2018-08-01 00:00:00

abstract：:Type 2 helper T cells (T(H)2) are critically involved in allergies and asthma. Here we demonstrate that extracellular matrix protein-1 (ECM1) is highly and selectively expressed in T(H)2 cells. ECM1 deficiency caused impaired T(H)2 responses and reduced allergic airway inflammation in vivo. Functional analysis demonst...

journal_title：Nature immunology

authors： Li Z,Zhang Y,Liu Z,Wu X,Zheng Y,Tao Z,Mao K,Wang J,Lin G,Tian L,Ji Y,Qin M,Sun S,Zhu X,Sun B

更新日期：2011-02-01 00:00:00

abstract：:Immune responses to microbial challenge in various tissues are not the same. Organ-specific immune responses are adapted to maintain organ physiology. ...

journal_title：Nature immunology

authors： Raz E

更新日期：2007-01-01 00:00:00

abstract：:A20 is an anti-inflammatory protein that is strongly linked to human disease. Here, we find that mice expressing three distinct targeted mutations of A20's zinc finger 7 (ZF7) ubiquitin-binding motif uniformly developed digit arthritis with features common to psoriatic arthritis, while mice expressing point mutations ...

journal_title：Nature immunology

authors： Razani B,Whang MI,Kim FS,Nakamura MC,Sun X,Advincula R,Turnbaugh JA,Pendse M,Tanbun P,Achacoso P,Turnbaugh PJ,Malynn BA,Ma A

更新日期：2020-04-01 00:00:00

abstract：:Inflammation is a fundamental protective response that sometimes goes awry and becomes a major cofactor in the pathogenesis of many chronic human diseases, including cancer. Here we review the evolutionary relationship and opposing functions of the transcription factor NF-κB in inflammation and cancer. Although it see...

journal_title：Nature immunology

authors： Ben-Neriah Y,Karin M

更新日期：2011-07-19 00:00:00

abstract：:Antigen receptor-mediated production of inositol-1,4,5-trisphosphate (Ins(1,4,5)P3) in lymphocytes triggers the release of Ca2+ from intracellular stores; this release of Ca2+ results in the opening of store-operated Ca2+ channels in the plasma membrane. Here we report that mice lacking Ins(1,4,5)P3 3-kinase B (Itpkb)...

journal_title：Nature immunology

authors： Miller AT,Sandberg M,Huang YH,Young M,Sutton S,Sauer K,Cooke MP

更新日期：2007-05-01 00:00:00

abstract：:Infection of erythrocytes with Plasmodium species induces clinical malaria. Parasite-specific CD4(+) T cells correlate with lower parasite burdens and severity of human malaria and are needed to control blood-stage infection in mice. However, the characteristics of CD4(+) T cells that determine protection or parasite ...

journal_title：Nature immunology

authors： Butler NS,Moebius J,Pewe LL,Traore B,Doumbo OK,Tygrett LT,Waldschmidt TJ,Crompton PD,Harty JT

更新日期：2011-12-11 00:00:00

abstract：:Newly activated CD8(+) T cells reprogram their metabolism to meet the extraordinary biosynthetic demands of clonal expansion; however, the signals that mediate metabolic reprogramming remain poorly defined. Here we demonstrate an essential role for sterol regulatory element-binding proteins (SREBPs) in the acquisition...

journal_title：Nature immunology

authors： Kidani Y,Elsaesser H,Hock MB,Vergnes L,Williams KJ,Argus JP,Marbois BN,Komisopoulou E,Wilson EB,Osborne TF,Graeber TG,Reue K,Brooks DG,Bensinger SJ

更新日期：2013-05-01 00:00:00

abstract：:A fundamental puzzle in immunology is how the immune system decides what types of immune responses to launch against different stimuli. Although much is known about control of T helper type 1 (T(H)1) and T(H)17 responses, the mechanisms that initiate T(H)2 and T regulatory (T(reg)) responses remain obscure. Emerging s...

journal_title：Nature immunology

authors： Pulendran B,Tang H,Manicassamy S

更新日期：2010-08-01 00:00:00

abstract：:Despite accumulating evidence that regulatory T cells play a crucial role in preventing autoimmunity, the processes underlying their generation during immune repertoire formation are unknown. We show here that interactions with a single self-peptide can induce thymocytes that bear an autoreactive T cell receptor (TCR)...

journal_title：Nature immunology

authors： Jordan MS,Boesteanu A,Reed AJ,Petrone AL,Holenbeck AE,Lerman MA,Naji A,Caton AJ

更新日期：2001-04-01 00:00:00

abstract：:Quantitative mass spectrometry reveals how CD4+ and CD8+ T cells restructure proteomes in response to antigen and mammalian target of rapamycin complex 1 (mTORC1). Analysis of copy numbers per cell of >9,000 proteins provides new understanding of T cell phenotypes, exposing the metabolic and protein synthesis machiner...

journal_title：Nature immunology

authors： Howden AJM,Hukelmann JL,Brenes A,Spinelli L,Sinclair LV,Lamond AI,Cantrell DA

更新日期：2019-11-01 00:00:00

abstract：:Post-translational modification of chemokines mediated by the dipeptidyl peptidase DPP4 (CD26) has been shown to negatively regulate lymphocyte trafficking, and its inhibition enhances T cell migration and tumor immunity by preserving functional chemokine CXCL10. By extending those initial findings to pre-clinical mod...

journal_title：Nature immunology

authors： Hollande C,Boussier J,Ziai J,Nozawa T,Bondet V,Phung W,Lu B,Duffy D,Paradis V,Mallet V,Eberl G,Sandoval W,Schartner JM,Pol S,Barreira da Silva R,Albert ML

更新日期：2019-03-01 00:00:00

abstract：:Clonal expansion and immunological memory are hallmark features of the mammalian adaptive immune response and essential for prolonged host control of pathogens. Recent work demonstrates that natural killer (NK) cells of the innate immune system also exhibit these adaptive traits during infection. Here we demonstrate t...

journal_title：Nature immunology

authors： Lau CM,Adams NM,Geary CD,Weizman OE,Rapp M,Pritykin Y,Leslie CS,Sun JC

更新日期：2018-09-01 00:00:00

abstract：:We used high-resolution mass spectrometry to map the cytotoxic T lymphocyte (CTL) proteome and the effect of the metabolic checkpoint kinase mTORC1 on CTLs. The CTL proteome was dominated by metabolic regulators and granzymes, and mTORC1 selectively repressed and promoted expression of a subset of CTL proteins (~10%)....

journal_title：Nature immunology

authors： Hukelmann JL,Anderson KE,Sinclair LV,Grzes KM,Murillo AB,Hawkins PT,Stephens LR,Lamond AI,Cantrell DA

更新日期：2016-01-01 00:00:00

abstract：:Toll-like receptor-4 activation by lipopolysaccharide (LPS) induces the expression of interferon-beta (IFN-beta) in a MyD88-independent manner. Here we report that mice devoid of the JAK protein tyrosine kinase family member, Tyk2, were resistant to shock induced by high doses of LPS. Basal and LPS-induced expression ...

journal_title：Nature immunology

authors： Karaghiosoff M,Steinborn R,Kovarik P,Kriegshäuser G,Baccarini M,Donabauer B,Reichart U,Kolbe T,Bogdan C,Leanderson T,Levy D,Decker T,Müller M

更新日期：2003-05-01 00:00:00

abstract：:Plant proteins belonging to the nucleotide-binding site-leucine-rich repeat (NBS-LRR) family are used for pathogen detection. Like the mammalian Nod-LRR protein 'sensors' that detect intracellular conserved pathogen-associated molecular patterns, plant NBS-LRR proteins detect pathogen-associated proteins, most often t...

journal_title：Nature immunology

authors： DeYoung BJ,Innes RW

更新日期：2006-12-01 00:00:00

abstract：:Healthy individuals of African ancestry have neutropenia that has been linked with the variant rs2814778(G) of the gene encoding atypical chemokine receptor 1 (ACKR1). This polymorphism selectively abolishes the expression of ACKR1 in erythroid cells, causing a Duffy-negative phenotype. Here we describe an unexpected ...

journal_title：Nature immunology

authors： Duchene J,Novitzky-Basso I,Thiriot A,Casanova-Acebes M,Bianchini M,Etheridge SL,Hub E,Nitz K,Artinger K,Eller K,Caamaño J,Rülicke T,Moss P,Megens RTA,von Andrian UH,Hidalgo A,Weber C,Rot A

更新日期：2017-07-01 00:00:00

abstract：:This corrects the article DOI: 10.1038/ni.3713. ...

journal_title：Nature immunology

authors： Mariño E,Richards JL,McLeod KH,Stanley D,Yap YA,Knight J,McKenzie C,Kranich J,Oliveira AC,Rossello FJ,Krishnamurthy B,Nefzger CM,Macia L,Thorburn A,Baxter AG,Morahan G,Wong LH,Polo JM,Moore RJ,Lockett TJ,Clarke JM

更新日期：2017-10-18 00:00:00

abstract：:Immunologists are being compelled to develop new high-dimensional perspectives of cellular heterogeneity and to determine which applications best exploit the power of mass cytometry and associated multiplex approaches. ...

journal_title：Nature immunology

authors： Newell EW,Cheng Y

更新日期：2016-07-19 00:00:00

abstract：:Regenerative stem cell-like memory (TSCM) CD8+ T cells persist longer and produce stronger effector functions. We found that MEK1/2 inhibition (MEKi) induces TSCM that have naive phenotype with self-renewability, enhanced multipotency and proliferative capacity. This is achieved by delaying cell division and enhancing...

journal_title：Nature immunology

authors： Verma V,Jafarzadeh N,Boi S,Kundu S,Jiang Z,Fan Y,Lopez J,Nandre R,Zeng P,Alolaqi F,Ahmad S,Gaur P,Barry ST,Valge-Archer VE,Smith PD,Banchereau J,Mkrtichyan M,Youngblood B,Rodriguez PC,Gupta S,Khleif SN

更新日期：2021-01-01 00:00:00

abstract：:Chemokines facilitate leukocyte migration and positioning as well as other processes such as angiogenesis and leukocyte degranulation. The burgeoning knowledge on chemokines and their receptors has influenced many aspects of immunology, in part because cell migration is intimately related to leukocyte function. This o...

journal_title：Nature immunology

authors： Mackay CR

更新日期：2001-02-01 00:00:00

abstract：:The detection of aberrant cells by natural killer (NK) cells is controlled by the integration of signals from activating and inhibitory ligands and from cytokines such as IL-15. We identified cytokine-inducible SH2-containing protein (CIS, encoded by Cish) as a critical negative regulator of IL-15 signaling in NK cell...

journal_title：Nature immunology

authors： Delconte RB,Kolesnik TB,Dagley LF,Rautela J,Shi W,Putz EM,Stannard K,Zhang JG,Teh C,Firth M,Ushiki T,Andoniou CE,Degli-Esposti MA,Sharp PP,Sanvitale CE,Infusini G,Liau NP,Linossi EM,Burns CJ,Carotta S,Gray DH,Se

更新日期：2016-07-01 00:00:00

abstract：:Macrophages are professional phagocytic cells that orchestrate innate immune responses and have considerable phenotypic diversity at different anatomical locations. However, the mechanisms that control the heterogeneity of tissue macrophages are not well characterized. Here we found that the nuclear receptor LXRα was ...

journal_title：Nature immunology

authors： A-Gonzalez N,Guillen JA,Gallardo G,Diaz M,de la Rosa JV,Hernandez IH,Casanova-Acebes M,Lopez F,Tabraue C,Beceiro S,Hong C,Lara PC,Andujar M,Arai S,Miyazaki T,Li S,Corbi AL,Tontonoz P,Hidalgo A,Castrillo A

更新日期：2013-08-01 00:00:00

abstract：:Autoreactive B cells have critical roles in a large diversity of autoimmune diseases, but the molecular pathways that control these cells remain poorly understood. We performed an in vivo functional screen of a lymphocyte-expressed microRNA library and identified miR-148a as a potent regulator of B cell tolerance. Ele...

journal_title：Nature immunology

authors： Gonzalez-Martin A,Adams BD,Lai M,Shepherd J,Salvador-Bernaldez M,Salvador JM,Lu J,Nemazee D,Xiao C

更新日期：2016-04-01 00:00:00

abstract：:B lymphocyte development and selection are central to adaptive immunity and self-tolerance. These processes require B cell receptor (BCR) signaling and occur in bone marrow, an environment with variable hypoxia, but whether hypoxia-inducible factor (HIF) is involved is unknown. We show that HIF activity is high in hum...

journal_title：Nature immunology

authors： Burrows N,Bashford-Rogers RJM,Bhute VJ,Peñalver A,Ferdinand JR,Stewart BJ,Smith JEG,Deobagkar-Lele M,Giudice G,Connor TM,Inaba A,Bergamaschi L,Smith S,Tran MGB,Petsalaki E,Lyons PA,Espeli M,Huntly BJP,Smith KGC,Corn

更新日期：2020-11-01 00:00:00

abstract：:The mechanisms that initiate T helper type 2 (T(H)2) responses are poorly understood. Here we demonstrate that cysteine protease-induced T(H)2 responses occur via 'cooperation' between migratory dermal dendritic cells (DCs) and basophils positive for interleukin 4 (IL-4). Subcutaneous immunization with papain plus ant...

journal_title：Nature immunology

authors： Tang H,Cao W,Kasturi SP,Ravindran R,Nakaya HI,Kundu K,Murthy N,Kepler TB,Malissen B,Pulendran B

更新日期：2010-07-01 00:00:00

abstract：:Mast cell activation induced by aggregation of Fc epsilon RI receptors with immunoglobulin E and antigen is mediated through the activation of multiple protein kinase cascades. Here we report that the regulatory protein RabGEF1 bound to Ras and negatively regulated Ras activation and its 'downstream' effector pathways...

journal_title：Nature immunology

authors： Tam SY,Tsai M,Snouwaert JN,Kalesnikoff J,Scherrer D,Nakae S,Chatterjea D,Bouley DM,Galli SJ

更新日期：2004-08-01 00:00:00

abstract：:Interleukin 7 (IL-7) and T cell antigen receptor signals have been proposed to be the main drivers of homeostatic T cell proliferation. However, it is not known why CD4(+) T cells undergo less-efficient homeostatic proliferation than CD8(+) T cells do. Here we show that systemic IL-7 concentrations increased during ly...

journal_title：Nature immunology

authors： Guimond M,Veenstra RG,Grindler DJ,Zhang H,Cui Y,Murphy RD,Kim SY,Na R,Hennighausen L,Kurtulus S,Erman B,Matzinger P,Merchant MS,Mackall CL

更新日期：2009-02-01 00:00:00