The microRNA miR-148a functions as a critical regulator of B cell tolerance and autoimmunity.

abstract：:The molecular mechanisms directing the development of 'natural' CD4+CD25+Foxp3+ regulatory T cells (T(reg) cells) in the thymus are not thoroughly understood. We show here that conditional deletion of transforming growth factor-beta receptor I (TbetaRI) in T cells blocked the appearance of CD4+CD25+Foxp3+ thymocytes a...

journal_title：Nature immunology

authors： Liu Y,Zhang P,Li J,Kulkarni AB,Perruche S,Chen W

更新日期：2008-06-01 00:00:00

abstract：:Hematopoiesis requires tight regulation of the hematopoietic stem cell (HSC) population; however, the dynamics of HSC use at steady state are uncertain. Over 3-7 months, we evaluated the repopulation and self-renewal of more than 600 individual human 'severe combined immunodeficiency mouse-repopulating cells' (SRCs), ...

journal_title：Nature immunology

authors： McKenzie JL,Gan OI,Doedens M,Wang JC,Dick JE

更新日期：2006-11-01 00:00:00

abstract：:Respiratory infections are common precursors to asthma exacerbations in children, but molecular immune responses that determine whether and how an infection causes an exacerbation are poorly understood. By using systems-scale network analysis, we identify repertoires of cellular transcriptional pathways that lead to a...

journal_title：Nature immunology

authors： Altman MC,Gill MA,Whalen E,Babineau DC,Shao B,Liu AH,Jepson B,Gruchalla RS,O'Connor GT,Pongracic JA,Kercsmar CM,Khurana Hershey GK,Zoratti EM,Johnson CC,Teach SJ,Kattan M,Bacharier LB,Beigelman A,Sigelman SM,Presnel

更新日期：2019-05-01 00:00:00

abstract：:The heterodimeric cytokine interleukin 27 (IL-27) signals through the IL-27Rα subunit of its receptor, combined with gp130, a common receptor chain used by several cytokines, including IL-6. Notably, the IL-27 subunits p28 (IL-27p28) and EBI3 are not always expressed together, which suggests that they may have unique ...

journal_title：Nature immunology

authors： Stumhofer JS,Tait ED,Quinn WJ 3rd,Hosken N,Spudy B,Goenka R,Fielding CA,O'Hara AC,Chen Y,Jones ML,Saris CJ,Rose-John S,Cua DJ,Jones SA,Elloso MM,Grötzinger J,Cancro MP,Levin SD,Hunter CA

更新日期：2010-12-01 00:00:00

abstract：:In addition to the conventional innate and acquired immune responses, complex organisms have evolved an array of dominant, constitutively expressed genes that suppress or prevent viral infections. Two major cellular defenses against infection by retroviruses are the Fv1 and TRIM5 class of inhibitors that target incomi...

journal_title：Nature immunology

authors： Bieniasz PD

更新日期：2004-11-01 00:00:00

abstract：:Although Moraxella catarrhalis and Neisseria meningitidis are important human pathogens, they often colonize the human respiratory tract without causing overt clinical symptoms. Both pathogens express structurally unrelated proteins that share the ability to stimulate the adhesion molecule CEACAM1 expressed on human c...

journal_title：Nature immunology

authors： Slevogt H,Zabel S,Opitz B,Hocke A,Eitel J,N'guessan PD,Lucka L,Riesbeck K,Zimmermann W,Zweigner J,Temmesfeld-Wollbrueck B,Suttorp N,Singer BB

更新日期：2008-11-01 00:00:00

abstract：:The final stages of restriction to the T cell lineage occur in the thymus after the entry of thymus-seeding progenitors (TSPs). The identity and lineage potential of TSPs remains unclear. Because the first embryonic TSPs enter a non-vascularized thymic rudiment, we were able to directly image and establish the functio...

journal_title：Nature immunology

authors： Luis TC,Luc S,Mizukami T,Boukarabila H,Thongjuea S,Woll PS,Azzoni E,Giustacchini A,Lutteropp M,Bouriez-Jones T,Vaidya H,Mead AJ,Atkinson D,Böiers C,Carrelha J,Macaulay IC,Patient R,Geissmann F,Nerlov C,Sandberg R,

更新日期：2016-12-01 00:00:00

abstract：:Toll-like receptors (TLRs) are key initiators of the innate immune response and promote adaptive immunity. Much has been learned about the role of TLRs in human immunity from studies linking TLR genetic variation with disease. First, monogenic disorders associated with complete deficiency in certain TLR pathways, such...

journal_title：Nature immunology

authors： Netea MG,Wijmenga C,O'Neill LA

更新日期：2012-05-18 00:00:00

abstract：:Interactions driven by the T cell antigen receptor (TCR) determine the lineage fate of CD4(+)CD8(+) thymocytes, but the molecular mechanisms that induce the lineage-determining transcription factors are unknown. Here we found that TCR-induced transcription factors Egr2 and Egr1 had higher and more-prolonged expression...

journal_title：Nature immunology

authors： Seiler MP,Mathew R,Liszewski MK,Spooner CJ,Barr K,Meng F,Singh H,Bendelac A

更新日期：2012-02-05 00:00:00

abstract：:Ingested antigens lead to the generation of effector T cells that secrete interleukin 4 (IL-4) rather than interferon-gamma (IFN-gamma) and are capable of influencing naive T cells in their immediate environment to do the same. Using chimeric mice generated by aggregation of two genotypically different embryos, we fou...

journal_title：Nature immunology

authors： Alpan O,Bachelder E,Isil E,Arnheiter H,Matzinger P

更新日期：2004-06-01 00:00:00

abstract：:Group 2 innate lymphoid cells (ILC2s) and CD4+ type 2 helper T cells (TH2 cells) are defined by their similar effector cytokines, which together mediate the features of allergic immunity. We found that tissue ILC2s and TH2 cells differentiated independently but shared overlapping effector function programs that were m...

journal_title：Nature immunology

authors： Van Dyken SJ,Nussbaum JC,Lee J,Molofsky AB,Liang HE,Pollack JL,Gate RE,Haliburton GE,Ye CJ,Marson A,Erle DJ,Locksley RM

更新日期：2016-12-01 00:00:00

abstract：:HPK1 is a Ste20-related serine-threonine kinase that inducibly associates with the adaptors SLP-76 and Gads after T cell receptor (TCR) signaling. Here, HPK1 deficiency resulted in enhanced TCR-induced phosphorylation of SLP-76, phospholipase C-gamma1 and the kinase Erk, more-persistent calcium flux, and increased pro...

journal_title：Nature immunology

authors： Shui JW,Boomer JS,Han J,Xu J,Dement GA,Zhou G,Tan TH

更新日期：2007-01-01 00:00:00

abstract：:We report here the identification of a ligand-receptor system that, upon engagement, leads to the establishment of an antiviral state. Three closely positioned genes on human chromosome 19 encode distinct but paralogous proteins, which we designate interferon-lambda1 (IFN-lambda1), IFN-lambda2 and IFN-lambda3 (tentati...

journal_title：Nature immunology

authors： Kotenko SV,Gallagher G,Baurin VV,Lewis-Antes A,Shen M,Shah NK,Langer JA,Sheikh F,Dickensheets H,Donnelly RP

更新日期：2003-01-01 00:00:00

abstract：:Chronic infection is difficult to overcome because of exhaustion or depletion of cytotoxic effector CD8(+) T cells (cytotoxic T lymphoytes (CTLs)). Here we report that signaling via Toll-like receptors (TLRs) induced intrahepatic aggregates of myeloid cells that enabled the population expansion of CTLs (iMATEs: 'intra...

journal_title：Nature immunology

authors： Huang LR,Wohlleber D,Reisinger F,Jenne CN,Cheng RL,Abdullah Z,Schildberg FA,Odenthal M,Dienes HP,van Rooijen N,Schmitt E,Garbi N,Croft M,Kurts C,Kubes P,Protzer U,Heikenwalder M,Knolle PA

更新日期：2013-06-01 00:00:00

abstract：:Inflammation is a fundamental protective response that sometimes goes awry and becomes a major cofactor in the pathogenesis of many chronic human diseases, including cancer. Here we review the evolutionary relationship and opposing functions of the transcription factor NF-κB in inflammation and cancer. Although it see...

journal_title：Nature immunology

authors： Ben-Neriah Y,Karin M

更新日期：2011-07-19 00:00:00

abstract：:Human CD4+ T cells that produce interleukin 22 are an essential component of skin defense and repair. New evidence shows that these T cells recognize CD1a-lipid complexes on Langerhans cells. ...

journal_title：Nature immunology

authors： Colonna M

更新日期：2010-12-01 00:00:00

abstract：:Rearrangement of immunoglobulin heavy-chain variable (V(H)) gene segments has been suggested to be regulated by interleukin 7 signaling in pro-B cells. However, the genetic evidence for this recombination pathway has been challenged. Furthermore, no molecular components that directly control V(H) gene rearrangement ha...

journal_title：Nature immunology

authors： Bertolino E,Reddy K,Medina KL,Parganas E,Ihle J,Singh H

更新日期：2005-08-01 00:00:00

abstract：:In the version of this Research Highlight initially published, the url for the linked article was incorrect ( https://doi.org/10.1172/JCI90647JCI90647 ). The correct link is https://doi.org/10.1172/JCI90647 . The error has been corrected in the HTML and PDF versions of the article. ...

journal_title：Nature immunology

authors： Fehervari Z

更新日期：2018-08-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature immunology

authors： Zhu C,Chen W,Lou J,Rittase W,Li K

更新日期：2019-12-01 00:00:00

abstract：:Using whole-genome microarray data sets of the Immunological Genome Project, we demonstrate a closer transcriptional relationship between NK cells and T cells than between any other leukocytes, distinguished by their shared expression of genes encoding molecules with similar signaling functions. Whereas resting NK cel...

journal_title：Nature immunology

authors： Bezman NA,Kim CC,Sun JC,Min-Oo G,Hendricks DW,Kamimura Y,Best JA,Goldrath AW,Lanier LL,Immunological Genome Project Consortium.

更新日期：2012-10-01 00:00:00

abstract：:The transcription factor BATF directly regulates key components of the formation and function of follicular helper T cells and antibody class switching in B cells. ...

journal_title：Nature immunology

authors： Ellyard JI,Vinuesa CG

更新日期：2011-06-01 00:00:00

abstract：:Post-translational modification of chemokines mediated by the dipeptidyl peptidase DPP4 (CD26) has been shown to negatively regulate lymphocyte trafficking, and its inhibition enhances T cell migration and tumor immunity by preserving functional chemokine CXCL10. By extending those initial findings to pre-clinical mod...

journal_title：Nature immunology

authors： Hollande C,Boussier J,Ziai J,Nozawa T,Bondet V,Phung W,Lu B,Duffy D,Paradis V,Mallet V,Eberl G,Sandoval W,Schartner JM,Pol S,Barreira da Silva R,Albert ML

更新日期：2019-03-01 00:00:00

abstract：:Macrophages are professional phagocytic cells that orchestrate innate immune responses and have considerable phenotypic diversity at different anatomical locations. However, the mechanisms that control the heterogeneity of tissue macrophages are not well characterized. Here we found that the nuclear receptor LXRα was ...

journal_title：Nature immunology

authors： A-Gonzalez N,Guillen JA,Gallardo G,Diaz M,de la Rosa JV,Hernandez IH,Casanova-Acebes M,Lopez F,Tabraue C,Beceiro S,Hong C,Lara PC,Andujar M,Arai S,Miyazaki T,Li S,Corbi AL,Tontonoz P,Hidalgo A,Castrillo A

更新日期：2013-08-01 00:00:00

abstract：:Activated T helper cells produce many cytokines, some of which are secreted through the immunological synapse toward the antigen-presenting cell. Here we have used immunocytochemistry, live-cell imaging and a surface-mediated secretion assay to show that there are two cytokine export pathways in T helper cells. Some c...

journal_title：Nature immunology

authors： Huse M,Lillemeier BF,Kuhns MS,Chen DS,Davis MM

更新日期：2006-03-01 00:00:00

abstract：:Regulatory T (Treg) cells suppress the development of inflammatory disease, but our knowledge of transcriptional regulators that control this function remains incomplete. Here we show that expression of Id2 and Id3 in Treg cells was required to suppress development of fatal inflammatory disease. We found that T cell a...

journal_title：Nature immunology

authors： Miyazaki M,Miyazaki K,Chen S,Itoi M,Miller M,Lu LF,Varki N,Chang AN,Broide DH,Murre C

更新日期：2014-08-01 00:00:00

abstract：:We identified a tumor-associated cytotoxic T lymphocyte (CTL) epitope derived from the widely expressed human MDM2 oncoprotein and were able to bypass self-tolerance to this tumor antigen in HLA-A*0201 (A2.1) transgenic mice and by generating A2.1-negative, allo-A2.1-restricted human T lymphocytes. A broad range of ma...

journal_title：Nature immunology

authors： Stanislawski T,Voss RH,Lotz C,Sadovnikova E,Willemsen RA,Kuball J,Ruppert T,Bolhuis RL,Melief CJ,Huber C,Stauss HJ,Theobald M

更新日期：2001-10-01 00:00:00

abstract：:The balance of myeloid populations and lymphoid populations must be well controlled. Here we found that osteopontin (OPN) skewed this balance during pathogenic conditions such as infection and autoimmunity. Notably, two isoforms of OPN exerted distinct effects in shifting this balance through cell-type-specific regula...

journal_title：Nature immunology

authors： Kanayama M,Xu S,Danzaki K,Gibson JR,Inoue M,Gregory SG,Shinohara ML

更新日期：2017-09-01 00:00:00

abstract：:T cells compete in the response to antigen in vivo and this competition may drive the affinity maturation of a secondary T cell response. Here we show that high-affinity T cells out-competed lower affinity T cells during a response to antigenic challenge in vivo. Although competition between T cells specific for diffe...

journal_title：Nature immunology

authors： Kedl RM,Schaefer BC,Kappler JW,Marrack P

更新日期：2002-01-01 00:00:00

abstract：:NLRX1 is unique among the nucleotide-binding-domain and leucine-rich-repeat (NLR) proteins in its mitochondrial localization and ability to negatively regulate antiviral innate immunity dependent on the adaptors MAVS and STING. However, some studies have suggested a positive regulatory role for NLRX1 in inducing antiv...

journal_title：Nature immunology

authors： Feng H,Lenarcic EM,Yamane D,Wauthier E,Mo J,Guo H,McGivern DR,González-López O,Misumi I,Reid LM,Whitmire JK,Ting JP,Duncan JA,Moorman NJ,Lemon SM

更新日期：2017-12-01 00:00:00

abstract：:The Fc receptor common gamma-chain (FcRgamma) is a widely expressed adaptor bearing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. We show here that basophils lacking FcRgamma developed normally and proliferated efficiently in response to inter...

journal_title：Nature immunology

authors： Hida S,Yamasaki S,Sakamoto Y,Takamoto M,Obata K,Takai T,Karasuyama H,Sugane K,Saito T,Taki S

更新日期：2009-02-01 00:00:00