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Molecular definition of the identity and activation of natural killer cells.

Abstract：

:Using whole-genome microarray data sets of the Immunological Genome Project, we demonstrate a closer transcriptional relationship between NK cells and T cells than between any other leukocytes, distinguished by their shared expression of genes encoding molecules with similar signaling functions. Whereas resting NK cells are known to share expression of a few genes with cytotoxic CD8(+) T cells, our transcriptome-wide analysis demonstrates that the commonalities extend to hundreds of genes, many encoding molecules with unknown functions. Resting NK cells demonstrate a 'preprimed' state compared with naive T cells, which allows NK cells to respond more rapidly to viral infection. Collectively, our data provide a global context for known and previously unknown molecular aspects of NK cell identity and function by delineating the genome-wide repertoire of gene expression of NK cells in various states.

journal_name

Nat Immunol

journal_title

Nature immunology

authors

Bezman NA,Kim CC,Sun JC,Min-Oo G,Hendricks DW,Kamimura Y,Best JA,Goldrath AW,Lanier LL,Immunological Genome Project Consortium.

doi

10.1038/ni.2395

subject

Has Abstract

pub_date

2012-10-01 00:00:00

pages

1000-9

issue

10

eissn

1529-2908

issn

1529-2916

pii

ni.2395

journal_volume

13

pub_type

杂志文章

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