Abstract:
:In recent years, a population of unconventional T cells called 'mucosal-associated invariant T cells' (MAIT cells) has captured the attention of immunologists and clinicians due to their abundance in humans, their involvement in a broad range of infectious and non-infectious diseases and their unusual specificity for microbial riboflavin-derivative antigens presented by the major histocompatibility complex (MHC) class I-like protein MR1. MAIT cells use a limited T cell antigen receptor (TCR) repertoire with public antigen specificities that are conserved across species. They can be activated by TCR-dependent and TCR-independent mechanisms and exhibit rapid, innate-like effector responses. Here we review evidence showing that MAIT cells are a key component of the immune system and discuss their basic biology, development, role in disease and immunotherapeutic potential.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Godfrey DI,Koay HF,McCluskey J,Gherardin NAdoi
10.1038/s41590-019-0444-8subject
Has Abstractpub_date
2019-09-01 00:00:00pages
1110-1128issue
9eissn
1529-2908issn
1529-2916pii
10.1038/s41590-019-0444-8journal_volume
20pub_type
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