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Antigen-specific NK cell memory in rhesus macaques.

Abstract：

:Natural killer (NK) cells have traditionally been considered nonspecific components of innate immunity, but recent studies have shown features of antigen-specific memory in mouse NK cells. However, it has remained unclear whether this phenomenon also exists in primates. We found that splenic and hepatic NK cells from SHIV(SF162P3)-infected and SIV(mac251)-infected macaques specifically lysed Gag- and Env-pulsed dendritic cells in an NKG2-dependent fashion, in contrast to NK cells from uninfected macaques. Moreover, splenic and hepatic NK cells from Ad26-vaccinated macaques efficiently lysed antigen-matched but not antigen-mismatched targets 5 years after vaccination. These data demonstrate that robust, durable, antigen-specific NK cell memory can be induced in primates after both infection and vaccination, and this finding could be important for the development of vaccines against HIV-1 and other pathogens.

journal_name

Nat Immunol

journal_title

Nature immunology

authors

Reeves RK,Li H,Jost S,Blass E,Li H,Schafer JL,Varner V,Manickam C,Eslamizar L,Altfeld M,von Andrian UH,Barouch DH

doi

10.1038/ni.3227

subject

Has Abstract

pub_date

2015-09-01 00:00:00

pages

927-32

issue

9

eissn

1529-2908

issn

1529-2916

pii

ni.3227

journal_volume

16

pub_type

杂志文章

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