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Innate immune recognition of viral infection.

Abstract：

:Induction of the antiviral innate immune response depends on recognition of viral components by host pattern-recognition receptors. Members of the Toll-like receptor family have emerged as key sensors that recognize viral components such as nucleic acids. Toll-like receptor signaling results in the production of type I interferon and inflammatory cytokines and leads to dendritic cell maturation and establishment of antiviral immunity. Cells also express cytoplasmic RNA helicases that function as alternative pattern-recognition receptors through recognition of double-stranded RNA produced during virus replication. These two classes of pattern-recognition receptor molecules are expressed in different intracellular compartments and induce type I interferon responses via distinct signaling pathways.

journal_name

Nat Immunol

journal_title

Nature immunology

authors

Kawai T,Akira S

doi

10.1038/ni1303

keywords:

subject

Has Abstract

pub_date

2006-02-01 00:00:00

pages

131-7

issue

2

eissn

1529-2908

issn

1529-2916

pii

ni1303

journal_volume

7

pub_type

杂志文章,评审

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