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Cortical sinus probing, S1P1-dependent entry and flow-based capture of egressing T cells.

Abstract：

:The cellular dynamics of the egress of lymphocytes from lymph nodes are poorly defined. Here we visualized the branched organization of lymph node cortical sinuses and found that after entry, some T cells were retained, whereas others returned to the parenchyma. T cells deficient in sphingosine 1-phosphate receptor type 1 probed the sinus surface but failed to enter the sinuses. In some sinuses, T cells became rounded and moved unidirectionally. T cells traveled from cortical sinuses into macrophage-rich sinus areas. Many T cells flowed from medullary sinuses into the subcapsular space. We propose a multistep model of lymph node egress in which cortical sinus probing is followed by entry dependent on sphingosine 1-phosphate receptor type 1, capture of cells in a sinus region with flow, and transport to medullary sinuses and the efferent lymph.

journal_name

Nat Immunol

journal_title

Nature immunology

authors

Grigorova IL,Schwab SR,Phan TG,Pham TH,Okada T,Cyster JG

doi

10.1038/ni.1682

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

58-65

issue

1

eissn

1529-2908

issn

1529-2916

pii

ni.1682

journal_volume

10

pub_type

杂志文章

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