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A cascade of protein kinase C isozymes promotes cytoskeletal polarization in T cells.

Abstract：

:Polarization of the T cell microtubule-organizing center (MTOC) toward the antigen-presenting cell (APC) is driven by the accumulation of diacylglycerol (DAG) at the immunological synapse (IS). The mechanisms that couple DAG to the MTOC are not known. By single-cell photoactivation of the T cell antigen receptor (TCR), we found that three distinct isoforms of protein kinase C (PKC) were recruited by DAG to the IS in two steps. PKC-ɛ and PKC-η accumulated first in a broad region of membrane, whereas PKC-θ arrived later in a smaller zone. Functional experiments indicated that PKC-θ was required for MTOC reorientation and that PKC-ɛ and PKC-η operated redundantly to promote the recruitment of PKC-θ and subsequent polarization responses. Our results establish a previously uncharacterized role for PKC proteins in T cell polarity.

journal_name

Nat Immunol

journal_title

Nature immunology

authors

Quann EJ,Liu X,Altan-Bonnet G,Huse M

doi

10.1038/ni.2033

subject

Has Abstract

pub_date

2011-05-22 00:00:00

pages

647-54

issue

7

eissn

1529-2908

issn

1529-2916

pii

ni.2033

journal_volume

12

pub_type

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