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Diversity of receptors binding HIV on dendritic cell subsets.

Abstract：

:The ability of HIV-1 to use dendritic cells (DCs) for transport and to transfer virus to activated T cells in the lymph node may be crucial in early HIV-1 pathogenesis. We have characterized primary DCs for the receptors involved in viral envelope attachment and observed that C-type lectin receptor (CLR) binding was predominant in skin DCs, whereas binding to emigrating and tonsil DCs was CD4-dependent. No one CLR was solely responsible for envelope binding on all skin DC subsets. DC-SIGN (DC-specific ICAM-3-grabbing nonintegrin) was only expressed by CD14(+)CDla(lo) dermal DCs. The mannose receptor was expressed by CD1a(hi) and CD14(+)CDla(lo) dermal DCs, and langerin was expressed by Langerhans cells. The diversity of CLRs able to bind HIV-1 in skin DCs may reflect their ability to bind a range of microbial glycoproteins.

journal_name

Nat Immunol

journal_title

Nature immunology

authors

Turville SG,Cameron PU,Handley A,Lin G,Pöhlmann S,Doms RW,Cunningham AL

doi

10.1038/ni841

keywords:

subject

Has Abstract

pub_date

2002-10-01 00:00:00

pages

975-83

issue

10

eissn

1529-2908

issn

1529-2916

pii

ni841

journal_volume

3

pub_type

杂志文章

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