Abstract:
:Cysteinyl leukotrienes are established mediators of bronchial asthma and have agonist roles analogous to those of histamine in allergic rhinitis. We now know that the substance originally termed slow-reacting substance of anaphylaxis was composed of three cysteinyl leukotrienes that act in the inflammatory response via receptors on smooth muscle and on bone marrow-derived inflammatory cells. K. Frank Austen describes the work culminating in the identification, biosynthesis and functional characterization of these moieties.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Austen KFdoi
10.1038/ni0208-113subject
Has Abstractpub_date
2008-02-01 00:00:00pages
113-5issue
2eissn
1529-2908issn
1529-2916pii
ni0208-113journal_volume
9pub_type
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