Abstract:
:The outcome after infection with the human immunodeficiency virus type 1 (HIV-1) is a complex phenotype determined by interactions among the pathogen, the human host and the surrounding environment. An impact of host genetic variation on HIV-1 susceptibility was identified early in the pandemic, with a major role attributed to the genes encoding class I human leukocyte antigens (HLA) and the chemokine receptor CCR5. Studies using genome-wide data sets have underscored the strength of these associations relative to variants located throughout the rest of the genome. However, the extent to which additional polymorphisms influence HIV-1 disease progression, and how much of the variability in outcome can be attributed to host genetics, remain largely unclear. Here we discuss findings concerning the functional impact of associated variants, outline methods for quantifying the host genetic component and examine how available genome-wide data sets may be leveraged to discover gene variants that affect the outcome of HIV-1 infection.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
McLaren PJ,Carrington Mdoi
10.1038/ni.3147subject
Has Abstractpub_date
2015-06-01 00:00:00pages
577-83issue
6eissn
1529-2908issn
1529-2916pii
ni.3147journal_volume
16pub_type
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pub_type: 评论,新闻
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2008-04-01 00:00:00
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doi:10.1038/ni.1607
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journal_title:Nature immunology
pub_type: 杂志文章,评审
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更新日期:2013-12-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
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pub_type: 杂志文章,已发布勘误
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