Abstract:
:Notch molecules are well conserved from Drosophila melanogaster to mammals and regulate a broad spectrum of various cell lineage commitment processes. Recent studies using inhibitors, transgenic mice and conditional loss-of-function approaches have demonstrated essential roles for Notch signaling in the differentiation of thymocytes and peripheral T cells, as well as B cells. Here we highlight parallels in the developmental regulation of mammalian lymphocytes and the D. melanogaster nervous system through Notch cooperation with the transcriptional regulators RBP-J (Su(H)), MINT (Hairless) and E2A (Ac-Sc-Da).
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Tanigaki K,Honjo Tdoi
10.1038/ni1453subject
Has Abstractpub_date
2007-05-01 00:00:00pages
451-6issue
5eissn
1529-2908issn
1529-2916pii
ni1453journal_volume
8pub_type
杂志文章,评审abstract::B cells are activated by two temporally distinct signals, the first provided by the binding of antigen to the B cell antigen receptor (BCR), and the second provided by helper T cells. Here we found that B cells responded to antigen by rapidly increasing their metabolic activity, including both oxidative phosphorylatio...
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pub_type: 杂志文章
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pub_type: 已发布勘误
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pub_type: 杂志文章
doi:10.1038/ni.2343
更新日期:2012-07-19 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
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更新日期:2015-09-01 00:00:00
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更新日期:2017-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-03-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
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更新日期:2014-03-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2364
更新日期:2012-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1038/ni.2180
更新日期:2011-12-11 00:00:00
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pub_type: 新闻
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更新日期:2009-07-01 00:00:00
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更新日期:2015-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-07-01 00:00:00
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pub_type: 已发布勘误
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更新日期:2019-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2012-06-17 00:00:00
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更新日期:2020-02-01 00:00:00
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journal_title:Nature immunology
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更新日期:2016-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2008-07-01 00:00:00
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pub_type: 杂志文章
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journal_title:Nature immunology
pub_type: 杂志文章
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更新日期:2014-02-01 00:00:00
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journal_title:Nature immunology
pub_type: 杂志文章
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更新日期:2006-05-01 00:00:00
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pub_type: 杂志文章,评审
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