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Deletion of a coordinate regulator of type 2 cytokine expression in mice.

Abstract：

:Mechanisms that underlie the patterning of cytokine expression in T helper (T(H)) cell subsets remain incompletely defined. An evolutionarily conserved approximately 400-bp noncoding sequence in the intergenic region between the genes Il4 and Il13, designated conserved noncoding sequence 1 (CNS-1), was deleted in mice. The capacity to develop T(H)2 cells was compromised in vitro and in vivo in the absence of CNS-1. Despite the profound effect in T cells, mast cells from CNS-1(-/-) mice maintained their capacity to produce interleukin 4. A T cell-specific element critical for the optimal expression of type 2 cytokines may represent the evolution of a regulatory sequence exploited by adaptive immunity.

journal_name

Nat Immunol

journal_title

Nature immunology

authors

Mohrs M,Blankespoor CM,Wang ZE,Loots GG,Afzal V,Hadeiba H,Shinkai K,Rubin EM,Locksley RM

doi

10.1038/ni0901-842

keywords:

subject

Has Abstract

pub_date

2001-09-01 00:00:00

pages

842-7

issue

9

eissn

1529-2908

issn

1529-2916

pii

ni0901-842

journal_volume

2

pub_type

杂志文章

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