Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion.

abstract：:The cellular dynamics of the egress of lymphocytes from lymph nodes are poorly defined. Here we visualized the branched organization of lymph node cortical sinuses and found that after entry, some T cells were retained, whereas others returned to the parenchyma. T cells deficient in sphingosine 1-phosphate receptor ty...

journal_title：Nature immunology

authors： Grigorova IL,Schwab SR,Phan TG,Pham TH,Okada T,Cyster JG

更新日期：2009-01-01 00:00:00

abstract：:Human CD4+ T cells that produce interleukin 22 are an essential component of skin defense and repair. New evidence shows that these T cells recognize CD1a-lipid complexes on Langerhans cells. ...

journal_title：Nature immunology

authors： Colonna M

更新日期：2010-12-01 00:00:00

abstract：:Toll-like receptors (TLRs) are key initiators of the innate immune response and promote adaptive immunity. Much has been learned about the role of TLRs in human immunity from studies linking TLR genetic variation with disease. First, monogenic disorders associated with complete deficiency in certain TLR pathways, such...

journal_title：Nature immunology

authors： Netea MG,Wijmenga C,O'Neill LA

更新日期：2012-05-18 00:00:00

abstract：:The extracellular protein Spätzle is required for activation of the Toll signaling pathway in the embryonic development and innate immune defense of Drosophila. Spätzle is synthesized as a pro-protein and is processed to a functional form by a serine protease. We show here that the mature form of Spätzle triggers a To...

journal_title：Nature immunology

authors： Weber AN,Tauszig-Delamasure S,Hoffmann JA,Lelièvre E,Gascan H,Ray KP,Morse MA,Imler JL,Gay NJ

更新日期：2003-08-01 00:00:00

abstract：:T cell receptor engagement in the absence of proper accessory signals leads to T cell anergy. E3 ligases are involved in maintaining the anergic state. However, the specific molecules responsible for the induction of anergy have yet to be elucidated. Using microarray analysis we have identified here early growth respo...

journal_title：Nature immunology

authors： Safford M,Collins S,Lutz MA,Allen A,Huang CT,Kowalski J,Blackford A,Horton MR,Drake C,Schwartz RH,Powell JD

更新日期：2005-05-01 00:00:00

abstract：:Clonal expansion and immunological memory are hallmark features of the mammalian adaptive immune response and essential for prolonged host control of pathogens. Recent work demonstrates that natural killer (NK) cells of the innate immune system also exhibit these adaptive traits during infection. Here we demonstrate t...

journal_title：Nature immunology

authors： Lau CM,Adams NM,Geary CD,Weizman OE,Rapp M,Pritykin Y,Leslie CS,Sun JC

更新日期：2018-09-01 00:00:00

abstract：:A20 is an anti-inflammatory protein that is strongly linked to human disease. Here, we find that mice expressing three distinct targeted mutations of A20's zinc finger 7 (ZF7) ubiquitin-binding motif uniformly developed digit arthritis with features common to psoriatic arthritis, while mice expressing point mutations ...

journal_title：Nature immunology

authors： Razani B,Whang MI,Kim FS,Nakamura MC,Sun X,Advincula R,Turnbaugh JA,Pendse M,Tanbun P,Achacoso P,Turnbaugh PJ,Malynn BA,Ma A

更新日期：2020-04-01 00:00:00

abstract：:T cell activation involves the orchestration of several signaling pathways, including that of the 'classical' transcription factor NF-kappaB components NF-kappaB1-RelA. The function of the 'nonclassical' NF-kappaB2-RelB pathway is less clear, although T cells lacking components of this pathway have activation defects....

journal_title：Nature immunology

authors： Ishimaru N,Kishimoto H,Hayashi Y,Sprent J

更新日期：2006-07-01 00:00:00

abstract：:Store-operated Ca2+ entry through calcium release-activated calcium channels is the chief mechanism for increasing intracellular Ca2+ in immune cells. Here we show that mouse T cells and fibroblasts lacking the calcium sensor STIM1 had severely impaired store-operated Ca2+ influx, whereas deficiency in the calcium sen...

journal_title：Nature immunology

authors： Oh-Hora M,Yamashita M,Hogan PG,Sharma S,Lamperti E,Chung W,Prakriya M,Feske S,Rao A

更新日期：2008-04-01 00:00:00

abstract：:Double-stranded DNA (dsDNA) in the cytoplasm triggers the production of interleukin 1β (IL-1β) as an antiviral host response, and deregulation of the pathways involved can promote inflammatory disease. Here we report a direct cytosolic interaction between the DNA-damage sensor Rad50 and the innate immune system adapto...

journal_title：Nature immunology

authors： Roth S,Rottach A,Lotz-Havla AS,Laux V,Muschaweckh A,Gersting SW,Muntau AC,Hopfner KP,Jin L,Vanness K,Petrini JH,Drexler I,Leonhardt H,Ruland J

更新日期：2014-06-01 00:00:00

abstract：:The detection of aberrant cells by natural killer (NK) cells is controlled by the integration of signals from activating and inhibitory ligands and from cytokines such as IL-15. We identified cytokine-inducible SH2-containing protein (CIS, encoded by Cish) as a critical negative regulator of IL-15 signaling in NK cell...

journal_title：Nature immunology

authors： Delconte RB,Kolesnik TB,Dagley LF,Rautela J,Shi W,Putz EM,Stannard K,Zhang JG,Teh C,Firth M,Ushiki T,Andoniou CE,Degli-Esposti MA,Sharp PP,Sanvitale CE,Infusini G,Liau NP,Linossi EM,Burns CJ,Carotta S,Gray DH,Se

更新日期：2016-07-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature immunology

authors： Bernink JH,Ohne Y,Teunissen MBM,Wang J,Wu J,Krabbendam L,Guntermann C,Volckmann R,Koster J,van Tol S,Ramirez I,Shrestha Y,de Rie MA,Spits H,Ros XR,Humbles AA

更新日期：2020-01-01 00:00:00

abstract：:DAP12-coupled receptors influence signals emanating from Toll-like receptors, integrins and receptors for cytokines and growth factors. New findings indicate that DAP12 also facilitates the ability of CSF-1R, the receptor for M-CSF, to induce the stabilization and nuclear translocation of beta-catenin. ...

journal_title：Nature immunology

authors： McVicar DW,Trinchieri G

更新日期：2009-07-01 00:00:00

abstract：:Polarization of the T cell microtubule-organizing center (MTOC) toward the antigen-presenting cell (APC) is driven by the accumulation of diacylglycerol (DAG) at the immunological synapse (IS). The mechanisms that couple DAG to the MTOC are not known. By single-cell photoactivation of the T cell antigen receptor (TCR)...

journal_title：Nature immunology

authors： Quann EJ,Liu X,Altan-Bonnet G,Huse M

更新日期：2011-05-22 00:00:00

abstract：:High-fat diet (HFD) and inflammation are key contributors to insulin resistance and type 2 diabetes (T2D). Interleukin (IL)-1β plays a role in insulin resistance, yet how IL-1β is induced by the fatty acids in an HFD, and how this alters insulin signaling, is unclear. We show that the saturated fatty acid palmitate, b...

journal_title：Nature immunology

authors： Wen H,Gris D,Lei Y,Jha S,Zhang L,Huang MT,Brickey WJ,Ting JP

更新日期：2011-05-01 00:00:00

abstract：:Dynamic changes in the expression of transcription factors (TFs) can influence the specification of distinct CD8+ T cell fates, but the observation of equivalent expression of TFs among differentially fated precursor cells suggests additional underlying mechanisms. Here we profiled the genome-wide histone modification...

journal_title：Nature immunology

authors： Yu B,Zhang K,Milner JJ,Toma C,Chen R,Scott-Browne JP,Pereira RM,Crotty S,Chang JT,Pipkin ME,Wang W,Goldrath AW

更新日期：2017-05-01 00:00:00

abstract：:Memory B cells are at the center of longstanding controversies regarding the presence of antigen for their survival and their re-engagement in germinal centers after secondary challenge. Using a new mouse model of memory B cell labeling dependent on the cytidine deaminase AID, we show that after immunization with a pa...

journal_title：Nature immunology

authors： Dogan I,Bertocci B,Vilmont V,Delbos F,Mégret J,Storck S,Reynaud CA,Weill JC

更新日期：2009-12-01 00:00:00

abstract：:Members of the Toll-like receptor (TLR) family are key regulators of both innate and adaptive immune responses. The function of TLRs in various human diseases has been investigated by comparison of the incidence of disease among people having different polymorphisms in genes that participate in TLR signaling. These st...

journal_title：Nature immunology

authors： Cook DN,Pisetsky DS,Schwartz DA

更新日期：2004-10-01 00:00:00

abstract：:The mechanisms that initiate T helper type 2 (T(H)2) responses are poorly understood. Here we demonstrate that cysteine protease-induced T(H)2 responses occur via 'cooperation' between migratory dermal dendritic cells (DCs) and basophils positive for interleukin 4 (IL-4). Subcutaneous immunization with papain plus ant...

journal_title：Nature immunology

authors： Tang H,Cao W,Kasturi SP,Ravindran R,Nakaya HI,Kundu K,Murthy N,Kepler TB,Malissen B,Pulendran B

更新日期：2010-07-01 00:00:00

abstract：:In the version of this article initially published, some identification of the supplementary information was incorrect. The items originally called Supplementary Tables 1, 2, 3, 4 and 5 should be Source Data Figures 1, 2, 4, 5 and 7, respectively; those originally called Supplementary Tables 6, 7 and 8 should be Suppl...

journal_title：Nature immunology

authors： Zhang M,Dong Y,Hu F,Yang D,Zhao Q,Lv C,Wang Y,Xia C,Weng Q,Liu X,Li C,Zhou P,Wang T,Guan Y,Guo R,Liu L,Geng Y,Wu H,Du J,Hu Z,Xu S,Chen J,He A,Liu B,Wang D,Yang YG,Wang J

更新日期：2018-09-01 00:00:00

abstract：:The lineage commitment of CD4+ T cells is coordinately regulated by signals through the T cell receptor and cytokine receptors, yet how these signals are integrated remains elusive. Here we find that mice lacking Dock2, a Rac activator in lymphocytes, developed allergic disease through a mechanism dependent on CD4+ T ...

journal_title：Nature immunology

authors： Tanaka Y,Hamano S,Gotoh K,Murata Y,Kunisaki Y,Nishikimi A,Takii R,Kawaguchi M,Inayoshi A,Masuko S,Himeno K,Sasazuki T,Fukui Y

更新日期：2007-10-01 00:00:00

abstract：:Immunological memory is thought to be mediated exclusively by lymphocytes. However, enhanced innate immune responses caused by a previous infection increase protection against reinfection, which suggests the presence of innate immunological memory. Here we identified an important role for the stress-response transcrip...

journal_title：Nature immunology

authors： Yoshida K,Maekawa T,Zhu Y,Renard-Guillet C,Chatton B,Inoue K,Uchiyama T,Ishibashi K,Yamada T,Ohno N,Shirahige K,Okada-Hatakeyama M,Ishii S

更新日期：2015-10-01 00:00:00

abstract：:Rearrangement of immunoglobulin heavy-chain variable (V(H)) gene segments has been suggested to be regulated by interleukin 7 signaling in pro-B cells. However, the genetic evidence for this recombination pathway has been challenged. Furthermore, no molecular components that directly control V(H) gene rearrangement ha...

journal_title：Nature immunology

authors： Bertolino E,Reddy K,Medina KL,Parganas E,Ihle J,Singh H

更新日期：2005-08-01 00:00:00

abstract：:CD8+ T cells play an important role in immunity to viruses. Just how important these cells are is demonstrated by the evolution of viral strategies for blocking the generation or display of peptide-major histocompatibility complex class I complexes on the surfaces of virus-infected cells. Here, we focus on viral inter...

journal_title：Nature immunology

authors： Yewdell JW,Hill AB

更新日期：2002-11-01 00:00:00

abstract：:Although approximately 200 viral microRNAs are known, only very few share similar targets with their host's microRNAs. A notable example of this is the stress-induced ligand MICB, which is targeted by several distinct viral and cellular microRNAs. Through the investigation of the microRNA-mediated immune-evasion strat...

journal_title：Nature immunology

authors： Nachmani D,Lankry D,Wolf DG,Mandelboim O

更新日期：2010-09-01 00:00:00

abstract：:EAE can refer either to experimental autoimmune encephalomyelitis or experimental allergic encephalomyelitis. Although EAE is classically a prototypic T helper 1 (TH1) cell-mediated autoimmune disease, it can also be induced by TH2 cells. Characteristically, the most severe manifestation of allergy, anaphylaxis, is as...

journal_title：Nature immunology

authors： Pedotti R,Mitchell D,Wedemeyer J,Karpuj M,Chabas D,Hattab EM,Tsai M,Galli SJ,Steinman L

更新日期：2001-03-01 00:00:00

abstract：:Group 2 innate lymphoid cells (ILC2s) and CD4+ type 2 helper T cells (TH2 cells) are defined by their similar effector cytokines, which together mediate the features of allergic immunity. We found that tissue ILC2s and TH2 cells differentiated independently but shared overlapping effector function programs that were m...

journal_title：Nature immunology

authors： Van Dyken SJ,Nussbaum JC,Lee J,Molofsky AB,Liang HE,Pollack JL,Gate RE,Haliburton GE,Ye CJ,Marson A,Erle DJ,Locksley RM

更新日期：2016-12-01 00:00:00

abstract：:The transcription factor STAT5 has a critical role in B cell acute lymphoblastic leukemia (B-ALL). How STAT5 mediates this effect is unclear. Here we found that activation of STAT5 worked together with defects in signaling components of the precursor to the B cell antigen receptor (pre-BCR), including defects in BLNK,...

journal_title：Nature immunology

authors： Katerndahl CDS,Heltemes-Harris LM,Willette MJL,Henzler CM,Frietze S,Yang R,Schjerven H,Silverstein KAT,Ramsey LB,Hubbard G,Wells AD,Kuiper RP,Scheijen B,van Leeuwen FN,Müschen M,Kornblau SM,Farrar MA

更新日期：2017-06-01 00:00:00

abstract：:Interactions driven by the T cell antigen receptor (TCR) determine the lineage fate of CD4(+)CD8(+) thymocytes, but the molecular mechanisms that induce the lineage-determining transcription factors are unknown. Here we found that TCR-induced transcription factors Egr2 and Egr1 had higher and more-prolonged expression...

journal_title：Nature immunology

authors： Seiler MP,Mathew R,Liszewski MK,Spooner CJ,Barr K,Meng F,Singh H,Bendelac A

更新日期：2012-02-05 00:00:00

abstract：:The activation of dendritic cells (DC) to produce interleukin 12 (IL-12) is thought to be a key step in the initiation of cell-mediated immunity to intracellular pathogens. Here we show that ligation of the C-C chemokine receptor (CCR) 5 can provide a major signal for the induction of IL-12 synthesis by the CD8 alpha+...

journal_title：Nature immunology

authors： Aliberti J,Reis e Sousa C,Schito M,Hieny S,Wells T,Huffnagle GB,Sher A

更新日期：2000-07-01 00:00:00