Abstract:
:The activation of dendritic cells (DC) to produce interleukin 12 (IL-12) is thought to be a key step in the initiation of cell-mediated immunity to intracellular pathogens. Here we show that ligation of the C-C chemokine receptor (CCR) 5 can provide a major signal for the induction of IL-12 synthesis by the CD8 alpha+ subset of DC and that this pathway is important in establishing interferon gamma-dependent resistance to the protozoan parasite Toxoplasma gondii. These findings support the concept that the early induction of chemokines by invading pathogens is a critical step not only for the recruitment of DC but also for the determination of their subsequent immunologic function.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Aliberti J,Reis e Sousa C,Schito M,Hieny S,Wells T,Huffnagle GB,Sher Adoi
10.1038/76957keywords:
subject
Has Abstractpub_date
2000-07-01 00:00:00pages
83-7issue
1eissn
1529-2908issn
1529-2916journal_volume
1pub_type
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