T cell sensing of antigen dose governs interactive behavior with dendritic cells and sets a threshold for T cell activation.

abstract：:The actin cytoskeleton seems to play two critical roles in the activation of T cells. One of these roles is T cell shape development and movement, including formation of the immunological synapse. The other is the formation of a scaffold for signaling components. This review focuses on the recent convergence of cell b...

journal_title：Nature immunology

authors： Dustin ML,Cooper JA

更新日期：2000-07-01 00:00:00

abstract：:The lineage commitment of CD4+ T cells is coordinately regulated by signals through the T cell receptor and cytokine receptors, yet how these signals are integrated remains elusive. Here we find that mice lacking Dock2, a Rac activator in lymphocytes, developed allergic disease through a mechanism dependent on CD4+ T ...

journal_title：Nature immunology

authors： Tanaka Y,Hamano S,Gotoh K,Murata Y,Kunisaki Y,Nishikimi A,Takii R,Kawaguchi M,Inayoshi A,Masuko S,Himeno K,Sasazuki T,Fukui Y

更新日期：2007-10-01 00:00:00

abstract：:The extracellular protein Spätzle is required for activation of the Toll signaling pathway in the embryonic development and innate immune defense of Drosophila. Spätzle is synthesized as a pro-protein and is processed to a functional form by a serine protease. We show here that the mature form of Spätzle triggers a To...

journal_title：Nature immunology

authors： Weber AN,Tauszig-Delamasure S,Hoffmann JA,Lelièvre E,Gascan H,Ray KP,Morse MA,Imler JL,Gay NJ

更新日期：2003-08-01 00:00:00

abstract：:High-fat diet (HFD) and inflammation are key contributors to insulin resistance and type 2 diabetes (T2D). Interleukin (IL)-1β plays a role in insulin resistance, yet how IL-1β is induced by the fatty acids in an HFD, and how this alters insulin signaling, is unclear. We show that the saturated fatty acid palmitate, b...

journal_title：Nature immunology

authors： Wen H,Gris D,Lei Y,Jha S,Zhang L,Huang MT,Brickey WJ,Ting JP

更新日期：2011-05-01 00:00:00

abstract：:Microbial DNA sequences containing unmethylated CpG dinucleotides activate Toll-like receptor 9 (TLR9). We have found that TLR9 is localized to the endoplasmic reticulum (ER) of dendritic cells (DCs) and macrophages. Because there is no precedent for immune receptor signaling in the ER, we investigated how TLR9 is act...

journal_title：Nature immunology

authors： Latz E,Schoenemeyer A,Visintin A,Fitzgerald KA,Monks BG,Knetter CF,Lien E,Nilsen NJ,Espevik T,Golenbock DT

更新日期：2004-02-01 00:00:00

abstract：:CD4(+) follicular helper T cells (T(FH) cells) are essential for germinal center (GC) responses and long-lived antibody responses. Here we report that naive CD4(+) T cells deficient in the transcription factor Foxp1 'preferentially' differentiated into T(FH) cells, which resulted in substantially enhanced GC and antib...

journal_title：Nature immunology

authors： Wang H,Geng J,Wen X,Bi E,Kossenkov AV,Wolf AI,Tas J,Choi YS,Takata H,Day TJ,Chang LY,Sprout SL,Becker EK,Willen J,Tian L,Wang X,Xiao C,Jiang P,Crotty S,Victora GD,Showe LC,Tucker HO,Erikson J,Hu H

更新日期：2014-07-01 00:00:00

abstract：:CD4+ T cell priming under T helper type I (T(H)1) or T(H)2 conditions gives rise to polarized cytokine gene expression. We found that in these conditions human naive T cells acquired stable histone hyperacetylation at either the Ifng or Il4 promoter. Effector memory T cells showed polarized cytokine gene acetylation p...

journal_title：Nature immunology

authors： Messi M,Giacchetto I,Nagata K,Lanzavecchia A,Natoli G,Sallusto F

更新日期：2003-01-01 00:00:00

abstract：:The gammadelta T cells are prevalent in the mucosal epithelia and are postulated to act as 'sentries' for maintaining tissue integrity. What these gammadelta T cells recognize is poorly defined, but given the restricted T cell receptor (TCR) repertoire, the idea that they are selected by self antigens of low complexit...

journal_title：Nature immunology

authors： Zhao H,Nguyen H,Kang J

更新日期：2005-12-01 00:00:00

abstract：:Dynamic changes in the expression of transcription factors (TFs) can influence the specification of distinct CD8+ T cell fates, but the observation of equivalent expression of TFs among differentially fated precursor cells suggests additional underlying mechanisms. Here we profiled the genome-wide histone modification...

journal_title：Nature immunology

authors： Yu B,Zhang K,Milner JJ,Toma C,Chen R,Scott-Browne JP,Pereira RM,Crotty S,Chang JT,Pipkin ME,Wang W,Goldrath AW

更新日期：2017-05-01 00:00:00

abstract：:T cell antigen receptor (TCR) signaling drives distinct responses depending on the differentiation state and context of CD8(+) T cells. We hypothesized that access of signal-dependent transcription factors (TFs) to enhancers is dynamically regulated to shape transcriptional responses to TCR signaling. We found that th...

journal_title：Nature immunology

authors： Roychoudhuri R,Clever D,Li P,Wakabayashi Y,Quinn KM,Klebanoff CA,Ji Y,Sukumar M,Eil RL,Yu Z,Spolski R,Palmer DC,Pan JH,Patel SJ,Macallan DC,Fabozzi G,Shih HY,Kanno Y,Muto A,Zhu J,Gattinoni L,O'Shea JJ,Okkenhau

更新日期：2016-07-01 00:00:00

abstract：:The activation of an immune response requires recognition of microorganisms by host receptors. In drosophila, detection of Gram-positive bacteria is mediated by cooperation between the peptidoglycan-recognition protein-SA (PGRP-SA) and Gram-negative binding protein 1 (GNBP1) proteins. Here we show that some Gram-posit...

journal_title：Nature immunology

authors： Bischoff V,Vignal C,Boneca IG,Michel T,Hoffmann JA,Royet J

更新日期：2004-11-01 00:00:00

abstract：:EAE can refer either to experimental autoimmune encephalomyelitis or experimental allergic encephalomyelitis. Although EAE is classically a prototypic T helper 1 (TH1) cell-mediated autoimmune disease, it can also be induced by TH2 cells. Characteristically, the most severe manifestation of allergy, anaphylaxis, is as...

journal_title：Nature immunology

authors： Pedotti R,Mitchell D,Wedemeyer J,Karpuj M,Chabas D,Hattab EM,Tsai M,Galli SJ,Steinman L

更新日期：2001-03-01 00:00:00

abstract：:In the version of this Research Highlight initially published, the url for the linked article was incorrect ( https://doi.org/10.1172/JCI90647JCI90647 ). The correct link is https://doi.org/10.1172/JCI90647 . The error has been corrected in the HTML and PDF versions of the article. ...

journal_title：Nature immunology

authors： Fehervari Z

更新日期：2018-08-01 00:00:00

abstract：:CD8+ T cells responding to chronic infections or tumors acquire an 'exhausted' state associated with elevated expression of inhibitory receptors, including PD-1, and impaired cytokine production. Exhausted T cells are continuously replenished by T cells with precursor characteristics that self-renew and depend on the ...

journal_title：Nature immunology

authors： Utzschneider DT,Gabriel SS,Chisanga D,Gloury R,Gubser PM,Vasanthakumar A,Shi W,Kallies A

更新日期：2020-10-01 00:00:00

abstract：:More than 20 years after the first successful engraftment of human leukocytes and hematopoietic organs in mice, scientists met for the 2nd International Workshop on Humanized Mice to discuss progress and to highlight expectations in this dynamic field. ...

journal_title：Nature immunology

authors： Manz MG,Di Santo JP

更新日期：2009-10-01 00:00:00

abstract：:NLRX1 is unique among the nucleotide-binding-domain and leucine-rich-repeat (NLR) proteins in its mitochondrial localization and ability to negatively regulate antiviral innate immunity dependent on the adaptors MAVS and STING. However, some studies have suggested a positive regulatory role for NLRX1 in inducing antiv...

journal_title：Nature immunology

authors： Feng H,Lenarcic EM,Yamane D,Wauthier E,Mo J,Guo H,McGivern DR,González-López O,Misumi I,Reid LM,Whitmire JK,Ting JP,Duncan JA,Moorman NJ,Lemon SM

更新日期：2017-12-01 00:00:00

abstract：:The manner in which regulatory T cells (Treg cells) control lymphocyte homeostasis is not fully understood. We identified two Treg cell populations with differing degrees of self-reactivity and distinct regulatory functions. We found that GITR(hi)PD-1(hi)CD25(hi) (Triple(hi)) Treg cells were highly self-reactive and c...

journal_title：Nature immunology

authors： Wyss L,Stadinski BD,King CG,Schallenberg S,McCarthy NI,Lee JY,Kretschmer K,Terracciano LM,Anderson G,Surh CD,Huseby ES,Palmer E

更新日期：2016-09-01 00:00:00

abstract：:Membrane recruitment of adaptor proteins is crucial for coupling antigen receptors to downstream signaling events. Despite the essential function of the B cell adaptor SLP-65, the mechanism of its recruitment to the plasma membrane is not yet understood. Here we show that a highly conserved leucine zipper in the SLP-6...

journal_title：Nature immunology

authors： Köhler F,Storch B,Kulathu Y,Herzog S,Kuppig S,Reth M,Jumaa H

更新日期：2005-02-01 00:00:00

abstract：:DAP12 is a signaling adaptor containing an immunoreceptor tyrosine-based activation motif (ITAM) that pairs with receptors on myeloid cells and natural killer cells. We examine here the responses of mice lacking DAP12 to stimulation through Toll-like receptors (TLRs). Unexpectedly, DAP12-deficient macrophages produced...

journal_title：Nature immunology

authors： Hamerman JA,Tchao NK,Lowell CA,Lanier LL

更新日期：2005-06-01 00:00:00

abstract：:αβ T cell antigen receptors (TCRs) bind complexes of peptide and major histocompatibility complex (pMHC) with low affinity, which poses a considerable challenge for the direct identification of αβ T cell cognate peptides. Here we describe a platform for the discovery of MHC class II epitopes based on the screening of ...

journal_title：Nature immunology

authors： Kisielow J,Obermair FJ,Kopf M

更新日期：2019-05-01 00:00:00

abstract：:Humoral autoimmunity paralleled by the accumulation of follicular helper T cells (T(FH) cells) is linked to mutation of the gene encoding the RNA-binding protein roquin-1. Here we found that T cells lacking roquin caused pathology in the lung and accumulated as cells of the T(H)17 subset of helper T cells in the lungs...

journal_title：Nature immunology

authors： Jeltsch KM,Hu D,Brenner S,Zöller J,Heinz GA,Nagel D,Vogel KU,Rehage N,Warth SC,Edelmann SL,Gloury R,Martin N,Lohs C,Lech M,Stehklein JE,Geerlof A,Kremmer E,Weber A,Anders HJ,Schmitz I,Schmidt-Supprian M,Fu M,H

更新日期：2014-11-01 00:00:00

abstract：:Tolerance to endotoxins that is triggered by prior exposure to Toll-like receptor (TLR) ligands provides a mechanism with which to dampen inflammatory cytokines. The receptor-interacting protein RIP140 interacts with the transcription factor NF-κB to regulate the expression of genes encoding proinflammatory cytokines....

journal_title：Nature immunology

authors： Ho PC,Tsui YC,Feng X,Greaves DR,Wei LN

更新日期：2012-03-04 00:00:00

abstract：:The active ubiquitin E3 ligase GRAIL is crucial in the induction of CD4 T cell anergy. Here we show that GRAIL is associated with and regulated by two isoforms of the ubiquitin-specific protease otubain 1. In lethally irradiated mice reconstituted with bone marrow cells from T cell receptor-transgenic mice retrovirall...

journal_title：Nature immunology

authors： Soares L,Seroogy C,Skrenta H,Anandasabapathy N,Lovelace P,Chung CD,Engleman E,Fathman CG

更新日期：2004-01-01 00:00:00

abstract：:Engineered crystallizable fragment (Fc) regions of antibody domains, which assume a unique and unprecedented asymmetric structure within the homodimeric Fc polypeptide, enable completely selective binding to the complement component C1q and activation of complement via the classical pathway without any concomitant eng...

journal_title：Nature immunology

authors： Lee CH,Romain G,Yan W,Watanabe M,Charab W,Todorova B,Lee J,Triplett K,Donkor M,Lungu OI,Lux A,Marshall N,Lindorfer MA,Goff OR,Balbino B,Kang TH,Tanno H,Delidakis G,Alford C,Taylor RP,Nimmerjahn F,Varadarajan N,

更新日期：2017-08-01 00:00:00

abstract：:Chronic inflammation has been strongly associated with tumor progression, but the underlying mechanisms remain elusive. Here we demonstrate that E3 ligase Itch and deubiquitinase Cyld formed a complex via interaction through 'WW-PPXY' motifs. The Itch-Cyld complex sequentially cleaved Lys63-linked ubiquitin chains and...

journal_title：Nature immunology

authors： Ahmed N,Zeng M,Sinha I,Polin L,Wei WZ,Rathinam C,Flavell R,Massoumi R,Venuprasad K

更新日期：2011-11-06 00:00:00

abstract：:The detection of aberrant cells by natural killer (NK) cells is controlled by the integration of signals from activating and inhibitory ligands and from cytokines such as IL-15. We identified cytokine-inducible SH2-containing protein (CIS, encoded by Cish) as a critical negative regulator of IL-15 signaling in NK cell...

journal_title：Nature immunology

authors： Delconte RB,Kolesnik TB,Dagley LF,Rautela J,Shi W,Putz EM,Stannard K,Zhang JG,Teh C,Firth M,Ushiki T,Andoniou CE,Degli-Esposti MA,Sharp PP,Sanvitale CE,Infusini G,Liau NP,Linossi EM,Burns CJ,Carotta S,Gray DH,Se

更新日期：2016-07-01 00:00:00

abstract：:The identification of pattern-recognition receptors that selectively respond to evolutionarily conserved chemical (often pathogen-derived) moieties has provided key insight into how innate immune cells facilitate rapid and relatively specific antimicrobial immune activity. In contrast, relatively slower adaptive immun...

journal_title：Nature immunology

authors： Hansen TH,Huang S,Arnold PL,Fremont DH

更新日期：2007-06-01 00:00:00

abstract：:CD160, a glycosylphosphatidylinositol-anchored member of the immunoglobulin superfamily, is expressed on both cytolytic lymphocytes and some unstimulated CD4+ T cells. Here we show that CD160 expression was increased after activation of human CD4+ T cells and that crosslinking CD160 with monoclonal antibody strongly i...

journal_title：Nature immunology

authors： Cai G,Anumanthan A,Brown JA,Greenfield EA,Zhu B,Freeman GJ

更新日期：2008-02-01 00:00:00

abstract：:Regulatory T (Treg) cells respond to immune and inflammatory signals to mediate immunosuppression, but how the functional integrity of Treg cells is maintained under activating environments is unclear. Here we show that autophagy is active in Treg cells and supports their lineage stability and survival fitness. Treg c...

journal_title：Nature immunology

authors： Wei J,Long L,Yang K,Guy C,Shrestha S,Chen Z,Wu C,Vogel P,Neale G,Green DR,Chi H

更新日期：2016-03-01 00:00:00

abstract：: ...

journal_title：Nature immunology

authors： Visan I

更新日期：2018-07-01 00:00:00