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Hydrogen peroxide as second messenger in lymphocyte activation.

Abstract：

:Oxidants such as H2O2 are connected to lymphocyte activation, but the molecular mechanisms behind this phenomenon are less clear. Here, I review data suggesting that by inhibiting protein tyrosine phosphatases, H2O2 plays an important role as a secondary messenger in the initiation and amplification of signaling at the antigen receptor. These findings explain why exposure of lymphocytes to H2O2 can mimic the effect of antigen. In addition, more recent data show that antigen receptors themselves are H2O2-generating enzymes and that the oxidative burst in macrophages seems to play a role not only in pathogen killing but also in the activation of these as well as neighboring cells. Thus, by controlling the activity of the negative regulatory phosphatases inside the cell, H2O2 can set and influence critical thresholds for lymphocyte activation.

journal_name

Nat Immunol

journal_title

Nature immunology

authors

Reth M

doi

10.1038/ni1202-1129

keywords:

subject

Has Abstract

pub_date

2002-12-01 00:00:00

pages

1129-34

issue

12

eissn

1529-2908

issn

1529-2916

pii

ni1202-1129

journal_volume

3

pub_type

杂志文章,评审

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