当前位置： SCI文献检索 > NATURE IMMUNOLOGY期刊下所有文献 > An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires.

An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires.

Abstract：

:The relationship between the T cell receptor (TCR) repertoires used by self-reactive transcription factor Foxp3-positive (Foxp3(+)) CD4(+) regulatory T cells (T(reg) cells) and nonregulatory T cells with autoimmune potential is unclear. Here we found that the TCR repertoire of thymic T(reg) cells in TCRbeta-transgenic mice was diverse and was more similar to that of peripheral T(reg) cells than that of nonregulatory T cells, suggesting that thymic T(reg) cells make a substantial contribution to the peripheral T(reg) cell population. Activated T cells in Foxp3-deficient mice, which lack T(reg) cells, 'preferentially' used TCRs found in the TCR repertoire of T(reg) cells in Foxp3-sufficient TCRbeta-transgenic mice, suggesting that these self-reactive TCRs contribute to the pathology of Foxp3-deficient mice. Our analyses suggest that T(reg) cells and potentially pathogenic autoimmune T cells use overlapping pools of self-reactive TCRs.

journal_name

Nat Immunol

journal_title

Nature immunology

authors

Hsieh CS,Zheng Y,Liang Y,Fontenot JD,Rudensky AY

doi

10.1038/ni1318

keywords:

subject

Has Abstract

pub_date

2006-04-01 00:00:00

pages

401-10

issue

4

eissn

1529-2908

issn

1529-2916

pii

ni1318

journal_volume

7

pub_type

杂志文章

相关文献

NATURE IMMUNOLOGY文献大全
  • High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3.

    abstract：:High-density lipoprotein (HDL) mediates reverse cholesterol transport and is known to be protective against atherosclerosis. In addition, HDL has potent anti-inflammatory properties that may be critical for protection against other inflammatory diseases. The molecular mechanisms of how HDL can modulate inflammation, p...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.2784

    authors： De Nardo D,Labzin LI,Kono H,Seki R,Schmidt SV,Beyer M,Xu D,Zimmer S,Lahrmann C,Schildberg FA,Vogelhuber J,Kraut M,Ulas T,Kerksiek A,Krebs W,Bode N,Grebe A,Fitzgerald ML,Hernandez NJ,Williams BR,Knolle P,Kneillin

    更新日期：2014-02-01 00:00:00

  • An innate antiviral pathway acting before interferons at epithelial surfaces.

    abstract：:Mucosal surfaces are exposed to environmental substances and represent a major portal of entry for microorganisms. The innate immune system is responsible for early defense against infections and it is believed that the interferons (IFNs) constitute the first line of defense against viruses. Here we identify an innate...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.3319

    authors： Iversen MB,Reinert LS,Thomsen MK,Bagdonaite I,Nandakumar R,Cheshenko N,Prabakaran T,Vakhrushev SY,Krzyzowska M,Kratholm SK,Ruiz-Perez F,Petersen SV,Goriely S,Bibby BM,Eriksson K,Ruland J,Thomsen AR,Herold BC,Wandall H

    更新日期：2016-02-01 00:00:00

  • Toll-like receptors in the pathogenesis of human disease.

    abstract：:Members of the Toll-like receptor (TLR) family are key regulators of both innate and adaptive immune responses. The function of TLRs in various human diseases has been investigated by comparison of the incidence of disease among people having different polymorphisms in genes that participate in TLR signaling. These st...

    journal_title：Nature immunology

    pub_type： 杂志文章,评审

    doi：10.1038/ni1116

    authors： Cook DN,Pisetsky DS,Schwartz DA

    更新日期：2004-10-01 00:00:00

  • Skewing of the population balance of lymphoid and myeloid cells by secreted and intracellular osteopontin.

    abstract：:The balance of myeloid populations and lymphoid populations must be well controlled. Here we found that osteopontin (OPN) skewed this balance during pathogenic conditions such as infection and autoimmunity. Notably, two isoforms of OPN exerted distinct effects in shifting this balance through cell-type-specific regula...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.3791

    authors： Kanayama M,Xu S,Danzaki K,Gibson JR,Inoue M,Gregory SG,Shinohara ML

    更新日期：2017-09-01 00:00:00

  • CEACAM1 inhibits Toll-like receptor 2-triggered antibacterial responses of human pulmonary epithelial cells.

    abstract：:Although Moraxella catarrhalis and Neisseria meningitidis are important human pathogens, they often colonize the human respiratory tract without causing overt clinical symptoms. Both pathogens express structurally unrelated proteins that share the ability to stimulate the adhesion molecule CEACAM1 expressed on human c...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.1661

    authors： Slevogt H,Zabel S,Opitz B,Hocke A,Eitel J,N'guessan PD,Lucka L,Riesbeck K,Zimmermann W,Zweigner J,Temmesfeld-Wollbrueck B,Suttorp N,Singer BB

    更新日期：2008-11-01 00:00:00

  • Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells.

    abstract：:Weak T cell antigen receptor (TCR) signals from contact with self ligands act in synergy with antiapoptotic signals induced by interleukin 7 (IL-7) to promote the survival of naive T cells in a resting state. The amount of background TCR signaling in naive T cells is set by post-thymic TCR tuning and operates at an in...

    journal_title：Nature immunology

    pub_type： 杂志文章,评审

    doi：10.1038/ni.2018

    authors： Sprent J,Surh CD

    更新日期：2011-06-01 00:00:00

  • Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling.

    abstract：:High-fat diet (HFD) and inflammation are key contributors to insulin resistance and type 2 diabetes (T2D). Interleukin (IL)-1β plays a role in insulin resistance, yet how IL-1β is induced by the fatty acids in an HFD, and how this alters insulin signaling, is unclear. We show that the saturated fatty acid palmitate, b...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.2022

    authors： Wen H,Gris D,Lei Y,Jha S,Zhang L,Huang MT,Brickey WJ,Ting JP

    更新日期：2011-05-01 00:00:00

  • F-box protein FBXL19-mediated ubiquitination and degradation of the receptor for IL-33 limits pulmonary inflammation.

    abstract：:The ST2L receptor for interleukin 33 (IL-33) mediates pulmonary inflammation and immune system-related disorders, such as asthma and rheumatoid arthritis. At present, very little is known about the molecular regulation of ST2L expression. Here we found that FBXL19, an 'orphan' member of the Skp1-Cullin-F-box family of...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.2341

    authors： Zhao J,Wei J,Mialki RK,Mallampalli DF,Chen BB,Coon T,Zou C,Mallampalli RK,Zhao Y

    更新日期：2012-06-03 00:00:00

  • STING and the innate immune response to nucleic acids in the cytosol.

    abstract：:Cytosolic detection of pathogen-derived nucleic acids is critical for the initiation of innate immune defense against diverse bacterial, viral and eukaryotic pathogens. Conversely, inappropriate responses to cytosolic nucleic acids can produce severe autoimmune pathology. The host protein STING has been identified as ...

    journal_title：Nature immunology

    pub_type： 杂志文章,评审

    doi：10.1038/ni.2491

    authors： Burdette DL,Vance RE

    更新日期：2013-01-01 00:00:00

  • Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule.

    abstract：:Cell death is achieved by two fundamentally different mechanisms: apoptosis and necrosis. Apoptosis is dependent on caspase activation, whereas the caspase-independent necrotic signaling pathway remains largely uncharacterized. We show here that Fas kills activated primary T cells efficiently in the absence of active ...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/82732

    authors： Holler N,Zaru R,Micheau O,Thome M,Attinger A,Valitutti S,Bodmer JL,Schneider P,Seed B,Tschopp J

    更新日期：2000-12-01 00:00:00

  • An unexpected version of horror autotoxicus: anaphylactic shock to a self-peptide.

    abstract：:EAE can refer either to experimental autoimmune encephalomyelitis or experimental allergic encephalomyelitis. Although EAE is classically a prototypic T helper 1 (TH1) cell-mediated autoimmune disease, it can also be induced by TH2 cells. Characteristically, the most severe manifestation of allergy, anaphylaxis, is as...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/85266

    authors： Pedotti R,Mitchell D,Wedemeyer J,Karpuj M,Chabas D,Hattab EM,Tsai M,Galli SJ,Steinman L

    更新日期：2001-03-01 00:00:00

  • The transcription factor BCL-6 controls early development of innate-like T cells.

    abstract：:Innate T cells, including invariant natural killer T (iNKT) and mucosal-associated innate T (MAIT) cells, are a heterogeneous T lymphocyte population with effector properties preprogrammed during their thymic differentiation. How this program is initiated is currently unclear. Here, we show that the transcription fact...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/s41590-020-0737-y

    authors： Gioulbasani M,Galaras A,Grammenoudi S,Moulos P,Dent AL,Sigvardsson M,Hatzis P,Kee BL,Verykokakis M

    更新日期：2020-09-01 00:00:00

  • Lipid length controls antigen entry into endosomal and nonendosomal pathways for CD1b presentation.

    abstract：:CD1 proteins present various glycolipid antigens to T cells, but the cellular mechanisms that control which particular glycolipids generate T cell responses are not understood. We show here that T cell recognition of glucose monomycolate antigens with long (C(80)) alkyl chains involves the delivery of CD1b proteins an...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni780

    authors： Moody DB,Briken V,Cheng TY,Roura-Mir C,Guy MR,Geho DH,Tykocinski ML,Besra GS,Porcelli SA

    更新日期：2002-05-01 00:00:00

  • New insights into the multidimensional concept of macrophage ontogeny, activation and function.

    abstract：:Macrophages have protective roles in immunity to pathogens, tissue development, homeostasis and repair following damage. Maladaptive immunity and inflammation provoke changes in macrophage function that are causative of disease. Despite a historical wealth of knowledge about macrophages, recent advances have revealed ...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.3324

    authors： Ginhoux F,Schultze JL,Murray PJ,Ochando J,Biswas SK

    更新日期：2016-01-01 00:00:00

  • MEK inhibition reprograms CD8+ T lymphocytes into memory stem cells with potent antitumor effects.

    abstract：:Regenerative stem cell-like memory (TSCM) CD8+ T cells persist longer and produce stronger effector functions. We found that MEK1/2 inhibition (MEKi) induces TSCM that have naive phenotype with self-renewability, enhanced multipotency and proliferative capacity. This is achieved by delaying cell division and enhancing...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/s41590-020-00818-9

    authors： Verma V,Jafarzadeh N,Boi S,Kundu S,Jiang Z,Fan Y,Lopez J,Nandre R,Zeng P,Alolaqi F,Ahmad S,Gaur P,Barry ST,Valge-Archer VE,Smith PD,Banchereau J,Mkrtichyan M,Youngblood B,Rodriguez PC,Gupta S,Khleif SN

    更新日期：2021-01-01 00:00:00

  • Transcriptional programming of dendritic cells for enhanced MHC class II antigen presentation.

    abstract：:CD11b(+) dendritic cells (DCs) seem to be specialized for presenting antigens via major histocompatibility (MHC) class II complexes to stimulate helper T cells, but the genetic and regulatory basis for this is not established. Conditional deletion of Irf4 resulted in loss of CD11b(+) DCs, impaired formation of peptide...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.2795

    authors： Vander Lugt B,Khan AA,Hackney JA,Agrawal S,Lesch J,Zhou M,Lee WP,Park S,Xu M,DeVoss J,Spooner CJ,Chalouni C,Delamarre L,Mellman I,Singh H

    更新日期：2014-02-01 00:00:00

  • Individual stem cells with highly variable proliferation and self-renewal properties comprise the human hematopoietic stem cell compartment.

    abstract：:Hematopoiesis requires tight regulation of the hematopoietic stem cell (HSC) population; however, the dynamics of HSC use at steady state are uncertain. Over 3-7 months, we evaluated the repopulation and self-renewal of more than 600 individual human 'severe combined immunodeficiency mouse-repopulating cells' (SRCs), ...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni1393

    authors： McKenzie JL,Gan OI,Doedens M,Wang JC,Dick JE

    更新日期：2006-11-01 00:00:00

  • Leukocyte extravasation and vascular permeability are each controlled in vivo by different tyrosine residues of VE-cadherin.

    abstract：:Tyrosine phosphorylation of the adhesion molecule VE-cadherin is assumed to affect endothelial junction integrity. However, it remains unclear whether tyrosine residues of VE-cadherin are required for the induction of vascular permeability and the regulation of leukocyte extravasation in vivo. We found here that knock...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.2824

    authors： Wessel F,Winderlich M,Holm M,Frye M,Rivera-Galdos R,Vockel M,Linnepe R,Ipe U,Stadtmann A,Zarbock A,Nottebaum AF,Vestweber D

    更新日期：2014-03-01 00:00:00

  • The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues.

    abstract：:Endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) appears to be specialized to produce peptides presented on class I major histocompatibility complex molecules. We found that purified ERAP1 trimmed peptides that were ten residues or longer, but spared eight-residue peptides. In vivo, ERAP1 enhanced production of an ...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni860

    authors： York IA,Chang SC,Saric T,Keys JA,Favreau JM,Goldberg AL,Rock KL

    更新日期：2002-12-01 00:00:00

  • Antagonism of B cell enhancer networks by STAT5 drives leukemia and poor patient survival.

    abstract：:The transcription factor STAT5 has a critical role in B cell acute lymphoblastic leukemia (B-ALL). How STAT5 mediates this effect is unclear. Here we found that activation of STAT5 worked together with defects in signaling components of the precursor to the B cell antigen receptor (pre-BCR), including defects in BLNK,...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.3716

    authors： Katerndahl CDS,Heltemes-Harris LM,Willette MJL,Henzler CM,Frietze S,Yang R,Schjerven H,Silverstein KAT,Ramsey LB,Hubbard G,Wells AD,Kuiper RP,Scheijen B,van Leeuwen FN,Müschen M,Kornblau SM,Farrar MA

    更新日期：2017-06-01 00:00:00

  • Loss of Ikaros DNA-binding function confers integrin-dependent survival on pre-B cells and progression to acute lymphoblastic leukemia.

    abstract：:Deletion of the DNA-binding domain of the transcription factor Ikaros generates dominant-negative isoforms that interfere with its activity and correlate with poor prognosis in human precursor B cell acute lymphoblastic leukemia (B-ALL). Here we found that conditional inactivation of the Ikaros DNA-binding domain in e...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.2821

    authors： Joshi I,Yoshida T,Jena N,Qi X,Zhang J,Van Etten RA,Georgopoulos K

    更新日期：2014-03-01 00:00:00

  • Infection of dendritic cells by murine cytomegalovirus induces functional paralysis.

    abstract：:Cytomegalovirus (CMV), measles and HIV are the main human pathogens known to induce immunosuppression. Unlike measles and HIV, and despite the availability of a well studied animal model, little is known about the mechanisms that control CMV-induced immunosuppression. We hypothesized that dendritic cells (DCs), which ...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni724

    authors： Andrews DM,Andoniou CE,Granucci F,Ricciardi-Castagnoli P,Degli-Esposti MA

    更新日期：2001-11-01 00:00:00

  • Improving the performance of enteric vaccines in the developing world.

    abstract：:Vaccines against important enteric pathogens such as rotavirus and poliovirus have shown lower efficacy in some populations. The application of new technologies and diverse scientific disciplines are needed to realize the promise of truly universal and effective solutions to combat those and other enteric diseases. ...

    journal_title：Nature immunology

    pub_type：

    doi：10.1038/ni0910-769

    authors： Serazin AC,Shackelton LA,Wilson C,Bhan MK

    更新日期：2010-09-01 00:00:00

  • The Drosophila immune system detects bacteria through specific peptidoglycan recognition.

    abstract：:The Drosophila immune system discriminates between different classes of infectious microbes and responds with pathogen-specific defense reactions through selective activation of the Toll and the immune deficiency (Imd) signaling pathways. The Toll pathway mediates most defenses against Gram-positive bacteria and fungi...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni922

    authors： Leulier F,Parquet C,Pili-Floury S,Ryu JH,Caroff M,Lee WJ,Mengin-Lecreulx D,Lemaitre B

    更新日期：2003-05-01 00:00:00

  • Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex.

    abstract：:Inhibitory natural killer (NK) cell receptors down-regulate the cytotoxicity of NK cells upon recognition of specific class I major histocompatibility complex (MHC) molecules on target cells. We report here the crystal structure of the inhibitory human killer cell immunoglobulin-like receptor 2DL1 (KIR2DL1) bound to i...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/87766

    authors： Fan QR,Long EO,Wiley DC

    更新日期：2001-05-01 00:00:00

  • Two isoforms of otubain 1 regulate T cell anergy via GRAIL.

    abstract：:The active ubiquitin E3 ligase GRAIL is crucial in the induction of CD4 T cell anergy. Here we show that GRAIL is associated with and regulated by two isoforms of the ubiquitin-specific protease otubain 1. In lethally irradiated mice reconstituted with bone marrow cells from T cell receptor-transgenic mice retrovirall...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni1017

    authors： Soares L,Seroogy C,Skrenta H,Anandasabapathy N,Lovelace P,Chung CD,Engleman E,Fathman CG

    更新日期：2004-01-01 00:00:00

  • Evolution and diversification of lamprey antigen receptors: evidence for involvement of an AID-APOBEC family cytosine deaminase.

    abstract：:The variable lymphocyte receptors (VLRs) of jawless vertebrates such as lamprey and hagfish are composed of highly diverse modular leucine-rich repeats. Each lymphocyte assembles a unique VLR by rearrangement of the germline gene. In the lamprey genome, we identify here about 850 distinct cassettes encoding leucine-ri...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni1463

    authors： Rogozin IB,Iyer LM,Liang L,Glazko GV,Liston VG,Pavlov YI,Aravind L,Pancer Z

    更新日期：2007-06-01 00:00:00

  • Intrinsic immunity: a front-line defense against viral attack.

    abstract：:In addition to the conventional innate and acquired immune responses, complex organisms have evolved an array of dominant, constitutively expressed genes that suppress or prevent viral infections. Two major cellular defenses against infection by retroviruses are the Fv1 and TRIM5 class of inhibitors that target incomi...

    journal_title：Nature immunology

    pub_type： 杂志文章,评审

    doi：10.1038/ni1125

    authors： Bieniasz PD

    更新日期：2004-11-01 00:00:00

  • IL-25-responsive, lineage-negative KLRG1(hi) cells are multipotential 'inflammatory' type 2 innate lymphoid cells.

    abstract：:Innate lymphoid cells (ILCs) are lymphocyte-like cells that lack T cell or B cell antigen receptors and mediate protective and repair functions through cytokine secretion. Among these, type 2 ILCs (ILC2 cells) are able to produce type 2 cytokines. We report the existence of an inflammatory ILC2 (iILC2) population resp...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.3078

    authors： Huang Y,Guo L,Qiu J,Chen X,Hu-Li J,Siebenlist U,Williamson PR,Urban JF Jr,Paul WE

    更新日期：2015-02-01 00:00:00

  • Defective survival of naive CD8+ T lymphocytes in the absence of the beta3 regulatory subunit of voltage-gated calcium channels.

    abstract：:The survival of T lymphocytes requires sustained, Ca(2+) influx-dependent gene expression. The molecular mechanism that governs sustained Ca(2+) influx in naive T lymphocytes is unknown. Here we report an essential role for the beta3 regulatory subunit of voltage-gated calcium (Ca(v)) channels in the maintenance of na...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.1793

    authors： Jha MK,Badou A,Meissner M,McRory JE,Freichel M,Flockerzi V,Flavell RA

    更新日期：2009-12-01 00:00:00