Drosha controls dendritic cell development by cleaving messenger RNAs encoding inhibitors of myelopoiesis.

abstract：:Nedd4 and Itch are E3 ubiquitin ligases that ubiquitinate similar targets in vitro and thus are thought to function similarly. T cells lacking Itch show spontaneous activation and T helper type 2 polarization. To test whether loss of Nedd4 affects T cells in the same way, we generated Nedd4(+/+) and Nedd4(-/-) fetal l...

journal_title：Nature immunology

authors： Yang B,Gay DL,MacLeod MK,Cao X,Hala T,Sweezer EM,Kappler J,Marrack P,Oliver PM

更新日期：2008-12-01 00:00:00

abstract：:Vaccines can have nonspecific effects through their modulation of responses to infections not specifically targeted by the vaccine. However, lack of knowledge about the underlying immunological mechanisms and molecular cause-and-effect relationships prevent use of this potentially powerful early-life intervention to i...

journal_title：Nature immunology

authors： Aaby P,Kollmann TR,Benn CS

更新日期：2014-10-01 00:00:00

abstract：:Regulatory T (Treg) cells suppress the development of inflammatory disease, but our knowledge of transcriptional regulators that control this function remains incomplete. Here we show that expression of Id2 and Id3 in Treg cells was required to suppress development of fatal inflammatory disease. We found that T cell a...

journal_title：Nature immunology

authors： Miyazaki M,Miyazaki K,Chen S,Itoi M,Miller M,Lu LF,Varki N,Chang AN,Broide DH,Murre C

更新日期：2014-08-01 00:00:00

abstract：:Although tissue-resident memory T cells (TRM cells) have been shown to regulate host protection in infectious disorders, their function in inflammatory bowel disease (IBD) remains to be investigated. Here we characterized TRM cells in human IBD and in experimental models of intestinal inflammation. Pro-inflammatory TR...

journal_title：Nature immunology

authors： Zundler S,Becker E,Spocinska M,Slawik M,Parga-Vidal L,Stark R,Wiendl M,Atreya R,Rath T,Leppkes M,Hildner K,López-Posadas R,Lukassen S,Ekici AB,Neufert C,Atreya I,van Gisbergen KPJM,Neurath MF

更新日期：2019-03-01 00:00:00

abstract：:The cellular dynamics of the egress of lymphocytes from lymph nodes are poorly defined. Here we visualized the branched organization of lymph node cortical sinuses and found that after entry, some T cells were retained, whereas others returned to the parenchyma. T cells deficient in sphingosine 1-phosphate receptor ty...

journal_title：Nature immunology

authors： Grigorova IL,Schwab SR,Phan TG,Pham TH,Okada T,Cyster JG

更新日期：2009-01-01 00:00:00

abstract：:FoxP3 conditions the transcriptional signature and functional facets of regulatory T cells (Treg cells). Its mechanism of action, whether as an activator or a repressor, has remained unclear. Here, chromatin analysis showed that FoxP3 bound active enhancer elements, not repressed chromatin, around loci over- or under-...

journal_title：Nature immunology

authors： Kwon HK,Chen HM,Mathis D,Benoist C

更新日期：2017-11-01 00:00:00

abstract：:Deficiency in mevalonate kinase (MVK) causes systemic inflammation. However, the molecular mechanisms linking the mevalonate pathway to inflammation remain obscure. Geranylgeranyl pyrophosphate, a non-sterol intermediate of the mevalonate pathway, is the substrate for protein geranylgeranylation, a protein post-transl...

journal_title：Nature immunology

authors： Akula MK,Shi M,Jiang Z,Foster CE,Miao D,Li AS,Zhang X,Gavin RM,Forde SD,Germain G,Carpenter S,Rosadini CV,Gritsman K,Chae JJ,Hampton R,Silverman N,Gravallese EM,Kagan JC,Fitzgerald KA,Kastner DL,Golenbock DT,Ber

更新日期：2016-08-01 00:00:00

abstract：:The mechanisms that lead to inflammation after necrotic cell death are poorly understood. New data show that the C-type lectin Mincle is involved in this process. ...

journal_title：Nature immunology

authors： Brown GD

更新日期：2008-10-01 00:00:00

abstract：:The final stages of restriction to the T cell lineage occur in the thymus after the entry of thymus-seeding progenitors (TSPs). The identity and lineage potential of TSPs remains unclear. Because the first embryonic TSPs enter a non-vascularized thymic rudiment, we were able to directly image and establish the functio...

journal_title：Nature immunology

authors： Luis TC,Luc S,Mizukami T,Boukarabila H,Thongjuea S,Woll PS,Azzoni E,Giustacchini A,Lutteropp M,Bouriez-Jones T,Vaidya H,Mead AJ,Atkinson D,Böiers C,Carrelha J,Macaulay IC,Patient R,Geissmann F,Nerlov C,Sandberg R,

更新日期：2016-12-01 00:00:00

abstract：:The autoimmune regulator Aire is expressed in a small proportion of medullary thymic epithelial cells (mTECs) and is crucial in the induction of central T cell tolerance. The origin and development of Aire(+) mTECs, however, are not well understood. Here we demonstrate that the tight-junction components claudin-3 and ...

journal_title：Nature immunology

authors： Hamazaki Y,Fujita H,Kobayashi T,Choi Y,Scott HS,Matsumoto M,Minato N

更新日期：2007-03-01 00:00:00

abstract：:Indoleamine 2,3 dioxygenase (IDO) activity during pregnancy protects developing fetuses from maternal immune responses in CBA mice. We show here that fetal allografts were rejected only in mating combinations where paternally inherited tissue antigens elicited potent maternal T cell responses after exposure to IDO inh...

journal_title：Nature immunology

authors： Mellor AL,Sivakumar J,Chandler P,Smith K,Molina H,Mao D,Munn DH

更新日期：2001-01-01 00:00:00

abstract：:Memory B cells are at the center of longstanding controversies regarding the presence of antigen for their survival and their re-engagement in germinal centers after secondary challenge. Using a new mouse model of memory B cell labeling dependent on the cytidine deaminase AID, we show that after immunization with a pa...

journal_title：Nature immunology

authors： Dogan I,Bertocci B,Vilmont V,Delbos F,Mégret J,Storck S,Reynaud CA,Weill JC

更新日期：2009-12-01 00:00:00

abstract：:Regulatory T cells (Treg cells) can express the transcription factors T-bet and GATA-3, but the function of this expression and whether such cells represent stable subsets is still unknown. By using various reporter tools, we found that the expression of T-bet and GATA-3 in Treg cells was dynamically influenced by the...

journal_title：Nature immunology

authors： Yu F,Sharma S,Edwards J,Feigenbaum L,Zhu J

更新日期：2015-02-01 00:00:00

abstract：:While a number of extrinsic factors are known to promote the survival of plasma cells (PCs), the signaling intermediates involved remain poorly characterized. Here we identified inducible nitric oxide synthase (iNOS) as an intermediate that supported the survival of PCs. PCs deficient in iNOS (Nos2(-/-) PCs) showed en...

journal_title：Nature immunology

authors： Saini AS,Shenoy GN,Rath S,Bal V,George A

更新日期：2014-03-01 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells generated during a large array of pathologic conditions ranging from cancer to obesity. These cells represent a pathologic state of activation of monocytes and relatively immature neutrophils. MDSCs are characterized by a distinct set of ...

journal_title：Nature immunology

authors： Veglia F,Perego M,Gabrilovich D

更新日期：2018-02-01 00:00:00

abstract：:Using whole-genome microarray data sets of the Immunological Genome Project, we demonstrate a closer transcriptional relationship between NK cells and T cells than between any other leukocytes, distinguished by their shared expression of genes encoding molecules with similar signaling functions. Whereas resting NK cel...

journal_title：Nature immunology

authors： Bezman NA,Kim CC,Sun JC,Min-Oo G,Hendricks DW,Kamimura Y,Best JA,Goldrath AW,Lanier LL,Immunological Genome Project Consortium.

更新日期：2012-10-01 00:00:00

abstract：: ...

journal_title：Nature immunology

authors： Visan I

更新日期：2018-07-01 00:00:00

abstract：:T cell receptor engagement in the absence of proper accessory signals leads to T cell anergy. E3 ligases are involved in maintaining the anergic state. However, the specific molecules responsible for the induction of anergy have yet to be elucidated. Using microarray analysis we have identified here early growth respo...

journal_title：Nature immunology

authors： Safford M,Collins S,Lutz MA,Allen A,Huang CT,Kowalski J,Blackford A,Horton MR,Drake C,Schwartz RH,Powell JD

更新日期：2005-05-01 00:00:00

abstract：:Diverse cellular responses to external cues are controlled by a small number of signal-transduction pathways, but how the specificity of functional outcomes is achieved remains unclear. Here we describe a mechanism for signal integration based on the functional coupling of two distinct signaling pathways widely used i...

journal_title：Nature immunology

authors： Bezbradica JS,Rosenstein RK,DeMarco RA,Brodsky I,Medzhitov R

更新日期：2014-04-01 00:00:00

abstract：:Mechanisms that underlie the patterning of cytokine expression in T helper (T(H)) cell subsets remain incompletely defined. An evolutionarily conserved approximately 400-bp noncoding sequence in the intergenic region between the genes Il4 and Il13, designated conserved noncoding sequence 1 (CNS-1), was deleted in mice...

journal_title：Nature immunology

authors： Mohrs M,Blankespoor CM,Wang ZE,Loots GG,Afzal V,Hadeiba H,Shinkai K,Rubin EM,Locksley RM

更新日期：2001-09-01 00:00:00

abstract：:More than 20 years after the first successful engraftment of human leukocytes and hematopoietic organs in mice, scientists met for the 2nd International Workshop on Humanized Mice to discuss progress and to highlight expectations in this dynamic field. ...

journal_title：Nature immunology

authors： Manz MG,Di Santo JP

更新日期：2009-10-01 00:00:00

abstract：:Autophagosomes delivers cytoplasmic constituents to lysosomes for degradation, whereas inflammasomes are molecular platforms activated by infection or stress that regulate the activity of caspase-1 and the maturation of interleukin 1β (IL-1β) and IL-18. Here we show that the induction of AIM2 or NLRP3 inflammasomes in...

journal_title：Nature immunology

authors： Shi CS,Shenderov K,Huang NN,Kabat J,Abu-Asab M,Fitzgerald KA,Sher A,Kehrl JH

更新日期：2012-01-29 00:00:00

abstract：:Using a human CD25 reporter transgene controlled by regulatory sequences from the gene encoding pre-T cell receptor alpha, we identified a common lymphocyte precursor (CLP-2) population that, in contrast to the previously identified CLP-1 population, was c-Kit-B220+. In short-term culture, the CLP-2 could be derived f...

journal_title：Nature immunology

authors： Martin CH,Aifantis I,Scimone ML,von Andrian UH,Reizis B,von Boehmer H,Gounari F

更新日期：2003-09-01 00:00:00

abstract：:Vaccines against important enteric pathogens such as rotavirus and poliovirus have shown lower efficacy in some populations. The application of new technologies and diverse scientific disciplines are needed to realize the promise of truly universal and effective solutions to combat those and other enteric diseases. ...

journal_title：Nature immunology

authors： Serazin AC,Shackelton LA,Wilson C,Bhan MK

更新日期：2010-09-01 00:00:00

abstract：:After homing to lymph nodes, CD8+ T cells are primed by dendritic cells (DCs) in three phases. During phase one, T cells undergo brief serial contacts with DCs for several hours, whereas phase two is characterized by stable T cell-DC interactions. We show here that the duration of phase one and T cell activation kinet...

journal_title：Nature immunology

authors： Henrickson SE,Mempel TR,Mazo IB,Liu B,Artyomov MN,Zheng H,Peixoto A,Flynn MP,Senman B,Junt T,Wong HC,Chakraborty AK,von Andrian UH

更新日期：2008-03-01 00:00:00

abstract：:Although approximately 200 viral microRNAs are known, only very few share similar targets with their host's microRNAs. A notable example of this is the stress-induced ligand MICB, which is targeted by several distinct viral and cellular microRNAs. Through the investigation of the microRNA-mediated immune-evasion strat...

journal_title：Nature immunology

authors： Nachmani D,Lankry D,Wolf DG,Mandelboim O

更新日期：2010-09-01 00:00:00

abstract：:We report here the identification of a ligand-receptor system that, upon engagement, leads to the establishment of an antiviral state. Three closely positioned genes on human chromosome 19 encode distinct but paralogous proteins, which we designate interferon-lambda1 (IFN-lambda1), IFN-lambda2 and IFN-lambda3 (tentati...

journal_title：Nature immunology

authors： Kotenko SV,Gallagher G,Baurin VV,Lewis-Antes A,Shen M,Shah NK,Langer JA,Sheikh F,Dickensheets H,Donnelly RP

更新日期：2003-01-01 00:00:00

abstract：:TET proteins oxidize 5-methylcytosine in DNA to 5-hydroxymethylcytosine and other oxidation products. We found that simultaneous deletion of Tet2 and Tet3 in mouse CD4+CD8+ double-positive thymocytes resulted in dysregulated development and proliferation of invariant natural killer T cells (iNKT cells). Tet2-Tet3 doub...

journal_title：Nature immunology

authors： Tsagaratou A,González-Avalos E,Rautio S,Scott-Browne JP,Togher S,Pastor WA,Rothenberg EV,Chavez L,Lähdesmäki H,Rao A

更新日期：2017-01-01 00:00:00

abstract：:Antibody specificity and diversity is generated in B cells during germinal center maturation through clonal expansion while they undergo class-switch recombination and somatic hypermutation. Here we demonstrate that the transcriptional repressor Bcl-6 mediates this phenotype by directly repressing ATR in centroblasts ...

journal_title：Nature immunology

authors： Ranuncolo SM,Polo JM,Dierov J,Singer M,Kuo T,Greally J,Green R,Carroll M,Melnick A

更新日期：2007-07-01 00:00:00

abstract：:Tyrosine kinases couple the T cell receptor (TCR) to discrete signaling cascades, each of which is capable of inducing a distinct functional outcome. Precisely how TCR signals are channeled toward specific targets remains unclear. TCR stimulation triggers 'alternative' activation of the mitogen-activated protein kinas...

journal_title：Nature immunology

authors： Round JL,Humphries LA,Tomassian T,Mittelstadt P,Zhang M,Miceli MC

更新日期：2007-02-01 00:00:00