Abstract:
:Regulatory T cells (Treg cells) can express the transcription factors T-bet and GATA-3, but the function of this expression and whether such cells represent stable subsets is still unknown. By using various reporter tools, we found that the expression of T-bet and GATA-3 in Treg cells was dynamically influenced by the cytokine environment. Treg cell-specific deletion of the gene encoding either T-bet (Tbx21) or GATA-3 (Gata3) alone did not result in loss of Treg cell function; however, mice with combined deficiency in both genes in Treg cells developed severe autoimmune-like diseases. Loss of Treg cell function correlated with upregulation of expression of the transcription factor RORγt and reduced expression of the transcription factor Foxp3. Thus, in the steady state, activated Treg cells transiently upregulated either T-bet or GATA-3 to maintain T cell homeostasis.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Yu F,Sharma S,Edwards J,Feigenbaum L,Zhu Jdoi
10.1038/ni.3053subject
Has Abstractpub_date
2015-02-01 00:00:00pages
197-206issue
2eissn
1529-2908issn
1529-2916pii
ni.3053journal_volume
16pub_type
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