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Mechanosensing through immunoreceptors.

Abstract：

:The immune response is orchestrated by a variety of immune cells. The function of each cell is determined by the collective signals from various immunoreceptors, whose expression and activity depend on the developmental stages of the cell and its environmental context. Recent studies have highlighted the presence of mechanical force on several immunoreceptor-ligand pairs and the important role of force in regulating their interaction and function. In this Perspective, we use the T cell antigen receptor as an example with which to review the current understanding of the mechanosensing properties of immunoreceptors. We discuss the types of forces that immunoreceptors may encounter and the effects of force on ligand bonding, conformational change and the triggering of immunoreceptors, as well as the effects of force on the downstream signal transduction, cell-fate decisions and effector function of immune cells.

journal_name

Nat Immunol

journal_title

Nature immunology

authors

Zhu C,Chen W,Lou J,Rittase W,Li K

doi

10.1038/s41590-019-0491-1

subject

Has Abstract

pub_date

2019-10-01 00:00:00

pages

1269-1278

issue

10

eissn

1529-2908

issn

1529-2916

pii

10.1038/s41590-019-0491-1

journal_volume

20

pub_type

杂志文章

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