Caspase-3 regulates cell cycle in B cells: a consequence of substrate specificity.

abstract：:Interleukin 7 (IL-7) and T cell antigen receptor signals have been proposed to be the main drivers of homeostatic T cell proliferation. However, it is not known why CD4(+) T cells undergo less-efficient homeostatic proliferation than CD8(+) T cells do. Here we show that systemic IL-7 concentrations increased during ly...

journal_title：Nature immunology

authors： Guimond M,Veenstra RG,Grindler DJ,Zhang H,Cui Y,Murphy RD,Kim SY,Na R,Hennighausen L,Kurtulus S,Erman B,Matzinger P,Merchant MS,Mackall CL

更新日期：2009-02-01 00:00:00

abstract：:The molecular mechanisms directing the development of 'natural' CD4+CD25+Foxp3+ regulatory T cells (T(reg) cells) in the thymus are not thoroughly understood. We show here that conditional deletion of transforming growth factor-beta receptor I (TbetaRI) in T cells blocked the appearance of CD4+CD25+Foxp3+ thymocytes a...

journal_title：Nature immunology

authors： Liu Y,Zhang P,Li J,Kulkarni AB,Perruche S,Chen W

更新日期：2008-06-01 00:00:00

abstract：:Effective clinical cancer immunotherapies, such as administration of the cytokine IL-2, adoptive cell transfer (ACT) and the recent success of blockade of the checkpoint modulators CTLA-4 and PD-1, have been developed without clear identification of the immunogenic targets expressed by human cancers in vivo. Immunothe...

journal_title：Nature immunology

authors： Tran E,Robbins PF,Rosenberg SA

更新日期：2017-02-15 00:00:00

abstract：:The ST2L receptor for interleukin 33 (IL-33) mediates pulmonary inflammation and immune system-related disorders, such as asthma and rheumatoid arthritis. At present, very little is known about the molecular regulation of ST2L expression. Here we found that FBXL19, an 'orphan' member of the Skp1-Cullin-F-box family of...

journal_title：Nature immunology

authors： Zhao J,Wei J,Mialki RK,Mallampalli DF,Chen BB,Coon T,Zou C,Mallampalli RK,Zhao Y

更新日期：2012-06-03 00:00:00

abstract：:Plant proteins belonging to the nucleotide-binding site-leucine-rich repeat (NBS-LRR) family are used for pathogen detection. Like the mammalian Nod-LRR protein 'sensors' that detect intracellular conserved pathogen-associated molecular patterns, plant NBS-LRR proteins detect pathogen-associated proteins, most often t...

journal_title：Nature immunology

authors： DeYoung BJ,Innes RW

更新日期：2006-12-01 00:00:00

abstract：:Cell death is achieved by two fundamentally different mechanisms: apoptosis and necrosis. Apoptosis is dependent on caspase activation, whereas the caspase-independent necrotic signaling pathway remains largely uncharacterized. We show here that Fas kills activated primary T cells efficiently in the absence of active ...

journal_title：Nature immunology

authors： Holler N,Zaru R,Micheau O,Thome M,Attinger A,Valitutti S,Bodmer JL,Schneider P,Seed B,Tschopp J

更新日期：2000-12-01 00:00:00

abstract：:The mechanisms that lead to inflammation after necrotic cell death are poorly understood. New data show that the C-type lectin Mincle is involved in this process. ...

journal_title：Nature immunology

authors： Brown GD

更新日期：2008-10-01 00:00:00

abstract：:Induction of the transcriptional repressor Bcl-6 in CD4(+) T cells is critical for the differentiation of follicular helper T cells (T(FH) cells), which are essential for B cell-mediated immunity. In contrast, the transcription factor Blimp1 (encoded by Prdm1) inhibits T(FH) differentiation by antagonizing Bcl-6. Here...

journal_title：Nature immunology

authors： Xu L,Cao Y,Xie Z,Huang Q,Bai Q,Yang X,He R,Hao Y,Wang H,Zhao T,Fan Z,Qin A,Ye J,Zhou X,Ye L,Wu Y

更新日期：2015-09-01 00:00:00

abstract：:The extracellular protein Spätzle is required for activation of the Toll signaling pathway in the embryonic development and innate immune defense of Drosophila. Spätzle is synthesized as a pro-protein and is processed to a functional form by a serine protease. We show here that the mature form of Spätzle triggers a To...

journal_title：Nature immunology

authors： Weber AN,Tauszig-Delamasure S,Hoffmann JA,Lelièvre E,Gascan H,Ray KP,Morse MA,Imler JL,Gay NJ

更新日期：2003-08-01 00:00:00

abstract：:The manner in which regulatory T cells (Treg cells) control lymphocyte homeostasis is not fully understood. We identified two Treg cell populations with differing degrees of self-reactivity and distinct regulatory functions. We found that GITR(hi)PD-1(hi)CD25(hi) (Triple(hi)) Treg cells were highly self-reactive and c...

journal_title：Nature immunology

authors： Wyss L,Stadinski BD,King CG,Schallenberg S,McCarthy NI,Lee JY,Kretschmer K,Terracciano LM,Anderson G,Surh CD,Huseby ES,Palmer E

更新日期：2016-09-01 00:00:00

abstract：:Neutrophils encounter and 'prioritize' many chemoattractants in their pursuit of bacteria. Here we tested the possibility that the phosphatase PTEN is responsible for the prioritization of chemoattractants. Neutrophils induced chemotaxis by two separate pathways, the phosphatidylinositol-3-OH kinase (PI(3)K) phosphata...

journal_title：Nature immunology

authors： Heit B,Robbins SM,Downey CM,Guan Z,Colarusso P,Miller BJ,Jirik FR,Kubes P

更新日期：2008-07-01 00:00:00

abstract：:Mice deficient for paired immunoglobulin (Ig)-like receptor B (PIR-B) show defective regulation of receptor-mediated activation in antigen-presenting cells. Older PIR-B(-/-) mice had an increased number of peritoneal B1 cells. Splenic PIR-B(-/-) B2 cells were constitutively activated and proliferated much more than th...

journal_title：Nature immunology

authors： Ujike A,Takeda K,Nakamura A,Ebihara S,Akiyama K,Takai T

更新日期：2002-06-01 00:00:00

abstract：:Autoreactive B cells have critical roles in a large diversity of autoimmune diseases, but the molecular pathways that control these cells remain poorly understood. We performed an in vivo functional screen of a lymphocyte-expressed microRNA library and identified miR-148a as a potent regulator of B cell tolerance. Ele...

journal_title：Nature immunology

authors： Gonzalez-Martin A,Adams BD,Lai M,Shepherd J,Salvador-Bernaldez M,Salvador JM,Lu J,Nemazee D,Xiao C

更新日期：2016-04-01 00:00:00

abstract：:High-affinity antibodies are critical for host protection and underlie successful vaccines. The generation of such antibodies requires T cell-dependent help, which mediates germinal center reactions in which mutation and selection of B cells occurs. Using an interleukin 4-reporter system, we show here that CD4(+) foll...

journal_title：Nature immunology

authors： Reinhardt RL,Liang HE,Locksley RM

更新日期：2009-04-01 00:00:00

abstract：:Induction of the antiviral innate immune response depends on recognition of viral components by host pattern-recognition receptors. Members of the Toll-like receptor family have emerged as key sensors that recognize viral components such as nucleic acids. Toll-like receptor signaling results in the production of type ...

journal_title：Nature immunology

authors： Kawai T,Akira S

更新日期：2006-02-01 00:00:00

abstract：:CD8+ T cells play an important role in immunity to viruses. Just how important these cells are is demonstrated by the evolution of viral strategies for blocking the generation or display of peptide-major histocompatibility complex class I complexes on the surfaces of virus-infected cells. Here, we focus on viral inter...

journal_title：Nature immunology

authors： Yewdell JW,Hill AB

更新日期：2002-11-01 00:00:00

abstract：:Plasticity is a hallmark of cells of the myelomonocytic lineage. In response to innate recognition or signals from lymphocyte subsets, mononuclear phagocytes undergo adaptive responses. Shaping of monocyte-macrophage function is an essential component of resistance to pathogens, tissue damage and repair. The orchestra...

journal_title：Nature immunology

authors： Biswas SK,Mantovani A

更新日期：2010-10-01 00:00:00

abstract：:Dendritic cells (DCs) initiate and regulate immunity against foreign and self antigens. Here we identified more than 200 individual major histocompatibility complex class II-associated peptides on human DCs and found that mature DCs selectively upregulated the self peptide CLIP. CLIP cosegregated together with foreign...

journal_title：Nature immunology

authors： Röhn TA,Boes M,Wolters D,Spindeldreher S,Müller B,Langen H,Ploegh H,Vogt AB,Kropshofer H

更新日期：2004-09-01 00:00:00

abstract：: ...

journal_title：Nature immunology

authors： Park JY,Park JH

更新日期：2018-11-01 00:00:00

abstract：:Current approaches for the treatment of obesity, including diet and lifestyle changes, have not been successful in curtailing the obesity epidemic. The higher incidence of inflammation-associated chronic disease and greater susceptibility to infection in obese people represents a growing health threat. Improved unders...

journal_title：Nature immunology

authors： Kanneganti TD,Dixit VD

更新日期：2012-07-19 00:00:00

abstract：:Emerging concepts suggest that the functional phenotype of macrophages is regulated by transcription factors that define alternative activation states. We found that RBP-J, the main nuclear transducer of signaling via Notch receptors, augmented Toll-like receptor 4 (TLR4)-induced expression of key mediators of classic...

journal_title：Nature immunology

authors： Xu H,Zhu J,Smith S,Foldi J,Zhao B,Chung AY,Outtz H,Kitajewski J,Shi C,Weber S,Saftig P,Li Y,Ozato K,Blobel CP,Ivashkiv LB,Hu X

更新日期：2012-05-20 00:00:00

abstract：:Interleukin 17 (IL-17)-producing T helper 17 cells (T(H)-17 cells) have been described as a T helper cell subset distinct from T helper type 1 (T(H)1) and T(H)2 cells, with specific functions in antimicrobial defense and autoimmunity. The factors driving human T(H)-17 differentiation remain controversial. Using a syst...

journal_title：Nature immunology

authors： Volpe E,Servant N,Zollinger R,Bogiatzi SI,Hupé P,Barillot E,Soumelis V

更新日期：2008-06-01 00:00:00

abstract：:The active ubiquitin E3 ligase GRAIL is crucial in the induction of CD4 T cell anergy. Here we show that GRAIL is associated with and regulated by two isoforms of the ubiquitin-specific protease otubain 1. In lethally irradiated mice reconstituted with bone marrow cells from T cell receptor-transgenic mice retrovirall...

journal_title：Nature immunology

authors： Soares L,Seroogy C,Skrenta H,Anandasabapathy N,Lovelace P,Chung CD,Engleman E,Fathman CG

更新日期：2004-01-01 00:00:00

abstract：:The activation of dendritic cells (DC) to produce interleukin 12 (IL-12) is thought to be a key step in the initiation of cell-mediated immunity to intracellular pathogens. Here we show that ligation of the C-C chemokine receptor (CCR) 5 can provide a major signal for the induction of IL-12 synthesis by the CD8 alpha+...

journal_title：Nature immunology

authors： Aliberti J,Reis e Sousa C,Schito M,Hieny S,Wells T,Huffnagle GB,Sher A

更新日期：2000-07-01 00:00:00

abstract：:Innate T cells, including invariant natural killer T (iNKT) and mucosal-associated innate T (MAIT) cells, are a heterogeneous T lymphocyte population with effector properties preprogrammed during their thymic differentiation. How this program is initiated is currently unclear. Here, we show that the transcription fact...

journal_title：Nature immunology

authors： Gioulbasani M,Galaras A,Grammenoudi S,Moulos P,Dent AL,Sigvardsson M,Hatzis P,Kee BL,Verykokakis M

更新日期：2020-09-01 00:00:00

abstract：:The mouse protein Qa-1 (HLA-E in humans) is essential for immunological protection and immune regulation. Although Qa-1 has been linked to CD8 T cell-dependent suppression, the physiological relevance of this observation is unclear. We generated mice deficient in Qa-1 to develop an understanding of this process. Qa-1-...

journal_title：Nature immunology

authors： Hu D,Ikizawa K,Lu L,Sanchirico ME,Shinohara ML,Cantor H

更新日期：2004-05-01 00:00:00

abstract：:CD4(+) follicular helper T cells (T(FH) cells) are essential for germinal center (GC) responses and long-lived antibody responses. Here we report that naive CD4(+) T cells deficient in the transcription factor Foxp1 'preferentially' differentiated into T(FH) cells, which resulted in substantially enhanced GC and antib...

journal_title：Nature immunology

authors： Wang H,Geng J,Wen X,Bi E,Kossenkov AV,Wolf AI,Tas J,Choi YS,Takata H,Day TJ,Chang LY,Sprout SL,Becker EK,Willen J,Tian L,Wang X,Xiao C,Jiang P,Crotty S,Victora GD,Showe LC,Tucker HO,Erikson J,Hu H

更新日期：2014-07-01 00:00:00

abstract：:Mucosal surfaces are exposed to environmental substances and represent a major portal of entry for microorganisms. The innate immune system is responsible for early defense against infections and it is believed that the interferons (IFNs) constitute the first line of defense against viruses. Here we identify an innate...

journal_title：Nature immunology

authors： Iversen MB,Reinert LS,Thomsen MK,Bagdonaite I,Nandakumar R,Cheshenko N,Prabakaran T,Vakhrushev SY,Krzyzowska M,Kratholm SK,Ruiz-Perez F,Petersen SV,Goriely S,Bibby BM,Eriksson K,Ruland J,Thomsen AR,Herold BC,Wandall H

更新日期：2016-02-01 00:00:00

abstract：:Invariant natural killer T cells (iNKT cells) are innate-like T lymphocytes that act as critical regulators of the immune response. To better characterize this population, we profiled gene expression in iNKT cells during ontogeny and in peripheral subsets as part of the Immunological Genome Project. High-resolution co...

journal_title：Nature immunology

authors： Cohen NR,Brennan PJ,Shay T,Watts GF,Brigl M,Kang J,Brenner MB,ImmGen Project Consortium.

更新日期：2013-01-01 00:00:00

abstract：:In addition to the conventional innate and acquired immune responses, complex organisms have evolved an array of dominant, constitutively expressed genes that suppress or prevent viral infections. Two major cellular defenses against infection by retroviruses are the Fv1 and TRIM5 class of inhibitors that target incomi...

journal_title：Nature immunology

authors： Bieniasz PD

更新日期：2004-11-01 00:00:00