Analysis of regulatory CD8 T cells in Qa-1-deficient mice.

abstract：:CD25(+)CD4(+) regulatory T cells in normal animals are engaged in the maintenance of immunological self-tolerance. We show here that glucocorticoid-induced tumor necrosis factor receptor family-related gene (GITR, also known as TNFRSF18)--a member of the tumor necrosis factor-nerve growth factor (TNF-NGF) receptor gen...

journal_title：Nature immunology

authors： Shimizu J,Yamazaki S,Takahashi T,Ishida Y,Sakaguchi S

更新日期：2002-02-01 00:00:00

abstract：:Although Moraxella catarrhalis and Neisseria meningitidis are important human pathogens, they often colonize the human respiratory tract without causing overt clinical symptoms. Both pathogens express structurally unrelated proteins that share the ability to stimulate the adhesion molecule CEACAM1 expressed on human c...

journal_title：Nature immunology

authors： Slevogt H,Zabel S,Opitz B,Hocke A,Eitel J,N'guessan PD,Lucka L,Riesbeck K,Zimmermann W,Zweigner J,Temmesfeld-Wollbrueck B,Suttorp N,Singer BB

更新日期：2008-11-01 00:00:00

abstract：:Current approaches for the treatment of obesity, including diet and lifestyle changes, have not been successful in curtailing the obesity epidemic. The higher incidence of inflammation-associated chronic disease and greater susceptibility to infection in obese people represents a growing health threat. Improved unders...

journal_title：Nature immunology

authors： Kanneganti TD,Dixit VD

更新日期：2012-07-19 00:00:00

abstract：:The ST2L receptor for interleukin 33 (IL-33) mediates pulmonary inflammation and immune system-related disorders, such as asthma and rheumatoid arthritis. At present, very little is known about the molecular regulation of ST2L expression. Here we found that FBXL19, an 'orphan' member of the Skp1-Cullin-F-box family of...

journal_title：Nature immunology

authors： Zhao J,Wei J,Mialki RK,Mallampalli DF,Chen BB,Coon T,Zou C,Mallampalli RK,Zhao Y

更新日期：2012-06-03 00:00:00

abstract：:Macrophages have protective roles in immunity to pathogens, tissue development, homeostasis and repair following damage. Maladaptive immunity and inflammation provoke changes in macrophage function that are causative of disease. Despite a historical wealth of knowledge about macrophages, recent advances have revealed ...

journal_title：Nature immunology

authors： Ginhoux F,Schultze JL,Murray PJ,Ochando J,Biswas SK

更新日期：2016-01-01 00:00:00

abstract：:Nedd4 and Itch are E3 ubiquitin ligases that ubiquitinate similar targets in vitro and thus are thought to function similarly. T cells lacking Itch show spontaneous activation and T helper type 2 polarization. To test whether loss of Nedd4 affects T cells in the same way, we generated Nedd4(+/+) and Nedd4(-/-) fetal l...

journal_title：Nature immunology

authors： Yang B,Gay DL,MacLeod MK,Cao X,Hala T,Sweezer EM,Kappler J,Marrack P,Oliver PM

更新日期：2008-12-01 00:00:00

abstract：:The transcription factor ThPOK promotes CD4(+) T cell differentiation in the thymus. Here, using a mouse strain that allows post-thymic gene deletion, we show that ThPOK maintains CD4(+) T lineage integrity and couples effector differentiation to environmental cues after antigenic stimulation. ThPOK preserved the inte...

journal_title：Nature immunology

authors： Vacchio MS,Wang L,Bouladoux N,Carpenter AC,Xiong Y,Williams LC,Wohlfert E,Song KD,Belkaid Y,Love PE,Bosselut R

更新日期：2014-10-01 00:00:00

abstract：:Healthy individuals of African ancestry have neutropenia that has been linked with the variant rs2814778(G) of the gene encoding atypical chemokine receptor 1 (ACKR1). This polymorphism selectively abolishes the expression of ACKR1 in erythroid cells, causing a Duffy-negative phenotype. Here we describe an unexpected ...

journal_title：Nature immunology

authors： Duchene J,Novitzky-Basso I,Thiriot A,Casanova-Acebes M,Bianchini M,Etheridge SL,Hub E,Nitz K,Artinger K,Eller K,Caamaño J,Rülicke T,Moss P,Megens RTA,von Andrian UH,Hidalgo A,Weber C,Rot A

更新日期：2017-07-01 00:00:00

abstract：:The present paradigm dictates that phagocytosis is accomplished mainly by 'professional' phagocytes (such as macrophages and monocytes), whereas B cells lack phagocytic capabilities. Here we demonstrate that B cells from teleost fish have potent in vitro and in vivo phagocytic activities. Particle uptake by B cells in...

journal_title：Nature immunology

authors： Li J,Barreda DR,Zhang YA,Boshra H,Gelman AE,Lapatra S,Tort L,Sunyer JO

更新日期：2006-10-01 00:00:00

abstract：:Regulatory T cells (T(reg) cells) develop from progenitor thymocytes after the engagement of T cell antigen receptors (TCRs) with high-affinity ligands, but the underlying molecular mechanisms are still unclear. Here we show that the Nr4a nuclear receptors, which are encoded by immediate-early genes upregulated by TCR...

journal_title：Nature immunology

authors： Sekiya T,Kashiwagi I,Yoshida R,Fukaya T,Morita R,Kimura A,Ichinose H,Metzger D,Chambon P,Yoshimura A

更新日期：2013-03-01 00:00:00

abstract：:The origin and specification of human dendritic cells (DCs) have not been investigated at the clonal level. Through the use of clonal assays, combined with statistical computation, to quantify the yield of granulocytes, monocytes, lymphocytes and three subsets of DCs from single human CD34+ progenitor cells, we found ...

journal_title：Nature immunology

authors： Lee J,Zhou YJ,Ma W,Zhang W,Aljoufi A,Luh T,Lucero K,Liang D,Thomsen M,Bhagat G,Shen Y,Liu K

更新日期：2017-08-01 00:00:00

abstract：:More than 20 years after the first successful engraftment of human leukocytes and hematopoietic organs in mice, scientists met for the 2nd International Workshop on Humanized Mice to discuss progress and to highlight expectations in this dynamic field. ...

journal_title：Nature immunology

authors： Manz MG,Di Santo JP

更新日期：2009-10-01 00:00:00

abstract：:Apoptosis signal-regulating kinase 1 (ASK1) is an evolutionarily conserved mitogen-activated protein 3-kinase that activates both Jnk and p38 mitogen-activated protein kinases. Here we used ASK1-deficient mice to show that ASK1 was selectively required for lipopolysaccharide-induced activation of p38 but not of Jnk or...

journal_title：Nature immunology

authors： Matsuzawa A,Saegusa K,Noguchi T,Sadamitsu C,Nishitoh H,Nagai S,Koyasu S,Matsumoto K,Takeda K,Ichijo H

更新日期：2005-06-01 00:00:00

abstract：:The immunopathogenesis of rheumatoid arthritis (RA) spans decades, beginning with the production of autoantibodies against post-translationally modified proteins (checkpoint 1). After years of asymptomatic autoimmunity and progressive immune system remodeling, tissue tolerance erodes and joint inflammation ensues as t...

journal_title：Nature immunology

authors： Weyand CM,Goronzy JJ

更新日期：2021-01-01 00:00:00

abstract：:CD8(+) T cells eliminate intracellular infections through two contact-dependent effector functions: cytolysis and secretion of antiviral cytokines. Here we identify the following additional function for memory CD8(+) T cells that persist at front-line sites of microbial exposure: to serve as local sensors of previousl...

journal_title：Nature immunology

authors： Schenkel JM,Fraser KA,Vezys V,Masopust D

更新日期：2013-05-01 00:00:00

abstract：:The transcription factor BATF is required for the differentiation of interleukin 17 (IL-17)-producing helper T cells (TH17 cells) and follicular helper T cells (TFH cells). Here we identified a fundamental role for BATF in regulating the differentiation of effector of CD8(+) T cells. BATF-deficient CD8(+) T cells show...

journal_title：Nature immunology

authors： Kurachi M,Barnitz RA,Yosef N,Odorizzi PM,DiIorio MA,Lemieux ME,Yates K,Godec J,Klatt MG,Regev A,Wherry EJ,Haining WN

更新日期：2014-04-01 00:00:00

abstract：:Programmed cell death is essential for the development and maintenance of the immune system and its responses to exogenous and endogenous stimuli. Studies have demonstrated that in addition to caspase-dependent apoptosis, necrosis dependent on the kinases RIP1 and RIP3 (also called necroptosis) is a major programmed c...

journal_title：Nature immunology

authors： Han J,Zhong CQ,Zhang DW

更新日期：2011-11-16 00:00:00

abstract：:EAE can refer either to experimental autoimmune encephalomyelitis or experimental allergic encephalomyelitis. Although EAE is classically a prototypic T helper 1 (TH1) cell-mediated autoimmune disease, it can also be induced by TH2 cells. Characteristically, the most severe manifestation of allergy, anaphylaxis, is as...

journal_title：Nature immunology

authors： Pedotti R,Mitchell D,Wedemeyer J,Karpuj M,Chabas D,Hattab EM,Tsai M,Galli SJ,Steinman L

更新日期：2001-03-01 00:00:00

abstract：:Viral infection induces type I interferons (IFN-alpha and IFN-beta) that recruit unexposed cells in a self-amplifying response. We report that the transcription factor MafB thwarts auto-amplification by a metastable switch activity. MafB acted as a weak positive basal regulator of transcription at the IFNB1 promoter t...

journal_title：Nature immunology

authors： Kim H,Seed B

更新日期：2010-08-01 00:00:00

abstract：:The variable lymphocyte receptors (VLRs) of jawless vertebrates such as lamprey and hagfish are composed of highly diverse modular leucine-rich repeats. Each lymphocyte assembles a unique VLR by rearrangement of the germline gene. In the lamprey genome, we identify here about 850 distinct cassettes encoding leucine-ri...

journal_title：Nature immunology

authors： Rogozin IB,Iyer LM,Liang L,Glazko GV,Liston VG,Pavlov YI,Aravind L,Pancer Z

更新日期：2007-06-01 00:00:00

abstract：:The glycolipid alpha-galactosylceramide binds with high affinity to CD1d and stimulates natural killer T cells. Here we report the crystal structure of human CD1d in complex with synthetic alpha-galactosylceramide at a resolution of 3.0 A. The structure shows a tightly fit lipid in the CD1d binding groove, with the sp...

journal_title：Nature immunology

authors： Koch M,Stronge VS,Shepherd D,Gadola SD,Mathew B,Ritter G,Fersht AR,Besra GS,Schmidt RR,Jones EY,Cerundolo V

更新日期：2005-08-01 00:00:00

abstract：:Mice deficient for paired immunoglobulin (Ig)-like receptor B (PIR-B) show defective regulation of receptor-mediated activation in antigen-presenting cells. Older PIR-B(-/-) mice had an increased number of peritoneal B1 cells. Splenic PIR-B(-/-) B2 cells were constitutively activated and proliferated much more than th...

journal_title：Nature immunology

authors： Ujike A,Takeda K,Nakamura A,Ebihara S,Akiyama K,Takai T

更新日期：2002-06-01 00:00:00

abstract：:Deletion of the DNA-binding domain of the transcription factor Ikaros generates dominant-negative isoforms that interfere with its activity and correlate with poor prognosis in human precursor B cell acute lymphoblastic leukemia (B-ALL). Here we found that conditional inactivation of the Ikaros DNA-binding domain in e...

journal_title：Nature immunology

authors： Joshi I,Yoshida T,Jena N,Qi X,Zhang J,Van Etten RA,Georgopoulos K

更新日期：2014-03-01 00:00:00

abstract：:The transcription factor c-Myb is expressed throughout T cell development in the thymus. However, little is understood about c-Myb function because of the embryonic lethality of traditional Myb-null mutations. Using tissue-specific deletion to abrogate c-Myb expression at distinct stages of T cell development, we iden...

journal_title：Nature immunology

authors： Bender TP,Kremer CS,Kraus M,Buch T,Rajewsky K

更新日期：2004-07-01 00:00:00

abstract：:The outcome after infection with the human immunodeficiency virus type 1 (HIV-1) is a complex phenotype determined by interactions among the pathogen, the human host and the surrounding environment. An impact of host genetic variation on HIV-1 susceptibility was identified early in the pandemic, with a major role attr...

journal_title：Nature immunology

authors： McLaren PJ,Carrington M

更新日期：2015-06-01 00:00:00

abstract：:Repair of tissue damaged during inflammatory processes is key to the return of local homeostasis and restoration of epithelial integrity. Here we describe CD161+ regulatory T (Treg) cells as a distinct, highly suppressive population of Treg cells that mediate wound healing. These Treg cells were enriched in intestinal...

journal_title：Nature immunology

authors： Povoleri GAM,Nova-Lamperti E,Scottà C,Fanelli G,Chen YC,Becker PD,Boardman D,Costantini B,Romano M,Pavlidis P,McGregor R,Pantazi E,Chauss D,Sun HW,Shih HY,Cousins DJ,Cooper N,Powell N,Kemper C,Pirooznia M,Laurence

更新日期：2018-12-01 00:00:00

abstract：:The manner in which regulatory T cells (Treg cells) control lymphocyte homeostasis is not fully understood. We identified two Treg cell populations with differing degrees of self-reactivity and distinct regulatory functions. We found that GITR(hi)PD-1(hi)CD25(hi) (Triple(hi)) Treg cells were highly self-reactive and c...

journal_title：Nature immunology

authors： Wyss L,Stadinski BD,King CG,Schallenberg S,McCarthy NI,Lee JY,Kretschmer K,Terracciano LM,Anderson G,Surh CD,Huseby ES,Palmer E

更新日期：2016-09-01 00:00:00

abstract：:Kinases of the Jak ('Janus kinase') family and transcription factors (TFs) of the STAT ('signal transducer and activator of transcription') family constitute a rapid membrane-to-nucleus signaling module that affects every aspect of the mammalian immune system. Research on this paradigmatic pathway has experienced brea...

journal_title：Nature immunology

authors： Villarino AV,Kanno Y,O'Shea JJ

更新日期：2017-03-22 00:00:00

abstract：:We report here the identification of a ligand-receptor system that, upon engagement, leads to the establishment of an antiviral state. Three closely positioned genes on human chromosome 19 encode distinct but paralogous proteins, which we designate interferon-lambda1 (IFN-lambda1), IFN-lambda2 and IFN-lambda3 (tentati...

journal_title：Nature immunology

authors： Kotenko SV,Gallagher G,Baurin VV,Lewis-Antes A,Shen M,Shah NK,Langer JA,Sheikh F,Dickensheets H,Donnelly RP

更新日期：2003-01-01 00:00:00

abstract：:Effective clinical cancer immunotherapies, such as administration of the cytokine IL-2, adoptive cell transfer (ACT) and the recent success of blockade of the checkpoint modulators CTLA-4 and PD-1, have been developed without clear identification of the immunogenic targets expressed by human cancers in vivo. Immunothe...

journal_title：Nature immunology

authors： Tran E,Robbins PF,Rosenberg SA

更新日期：2017-02-15 00:00:00