Regulating MAVS.

abstract：: ...

journal_title：Nature immunology

authors： Visan I

更新日期：2018-07-01 00:00:00

abstract：:Toll-like receptor (TLR) signaling activates the inhibitor of transcription factor NF-κB (IκB) kinase (IKK) complex, which governs NF-κB-mediated transcription during inflammation. The RNase regnase-1 serves a critical role in preventing autoimmunity by controlling the stability of mRNAs that encode cytokines. Here we...

journal_title：Nature immunology

authors： Iwasaki H,Takeuchi O,Teraguchi S,Matsushita K,Uehata T,Kuniyoshi K,Satoh T,Saitoh T,Matsushita M,Standley DM,Akira S

更新日期：2011-10-30 00:00:00

abstract：:Most antigenic peptides presented by major histocompatibility complex (MHC) class I molecules are produced by the proteasome. Here we show that a proteasome-independent peptide derived from the human tumor protein MAGE-A3 is produced directly by insulin-degrading enzyme (IDE), a cytosolic metallopeptidase. Cytotoxic T...

journal_title：Nature immunology

authors： Parmentier N,Stroobant V,Colau D,de Diesbach P,Morel S,Chapiro J,van Endert P,Van den Eynde BJ

更新日期：2010-05-01 00:00:00

abstract：:Cell death is achieved by two fundamentally different mechanisms: apoptosis and necrosis. Apoptosis is dependent on caspase activation, whereas the caspase-independent necrotic signaling pathway remains largely uncharacterized. We show here that Fas kills activated primary T cells efficiently in the absence of active ...

journal_title：Nature immunology

authors： Holler N,Zaru R,Micheau O,Thome M,Attinger A,Valitutti S,Bodmer JL,Schneider P,Seed B,Tschopp J

更新日期：2000-12-01 00:00:00

abstract：:Fc epsilon RI activation of mast cells is thought to involve Lyn and Syk kinases proximal to the receptor and the signaling complex organized by the linker for activation of T cells (LAT). We report here that Fc epsilon RI also uses a Fyn kinase-dependent pathway that does not require Lyn kinase or the adapter LAT for...

journal_title：Nature immunology

authors： Parravicini V,Gadina M,Kovarova M,Odom S,Gonzalez-Espinosa C,Furumoto Y,Saitoh S,Samelson LE,O'Shea JJ,Rivera J

更新日期：2002-08-01 00:00:00

abstract：:As part of the most important contributions to the understanding of viral immunity, Michael Oldstone recounts his pioneering work on lymphocytic choriomeningitis virus. ...

journal_title：Nature immunology

authors： Oldstone MB

更新日期：2007-04-01 00:00:00

abstract：:Oxidants such as H2O2 are connected to lymphocyte activation, but the molecular mechanisms behind this phenomenon are less clear. Here, I review data suggesting that by inhibiting protein tyrosine phosphatases, H2O2 plays an important role as a secondary messenger in the initiation and amplification of signaling at th...

journal_title：Nature immunology

authors： Reth M

更新日期：2002-12-01 00:00:00

abstract：:FoxP3 conditions the transcriptional signature and functional facets of regulatory T cells (Treg cells). Its mechanism of action, whether as an activator or a repressor, has remained unclear. Here, chromatin analysis showed that FoxP3 bound active enhancer elements, not repressed chromatin, around loci over- or under-...

journal_title：Nature immunology

authors： Kwon HK,Chen HM,Mathis D,Benoist C

更新日期：2017-11-01 00:00:00

abstract：:The gammadelta T cells are prevalent in the mucosal epithelia and are postulated to act as 'sentries' for maintaining tissue integrity. What these gammadelta T cells recognize is poorly defined, but given the restricted T cell receptor (TCR) repertoire, the idea that they are selected by self antigens of low complexit...

journal_title：Nature immunology

authors： Zhao H,Nguyen H,Kang J

更新日期：2005-12-01 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Nature immunology

authors： Zhu C,Chen W,Lou J,Rittase W,Li K

更新日期：2019-12-01 00:00:00

abstract：:Regions of the normal arterial intima predisposed to atherosclerosis are sites of ongoing monocyte trafficking and also contain resident myeloid cells with features of dendritic cells. However, the pathophysiological roles of these cells are poorly understood. Here we found that intimal myeloid cells underwent reverse...

journal_title：Nature immunology

authors： Roufaiel M,Gracey E,Siu A,Zhu SN,Lau A,Ibrahim H,Althagafi M,Tai K,Hyduk SJ,Cybulsky KO,Ensan S,Li A,Besla R,Becker HM,Xiao H,Luther SA,Inman RD,Robbins CS,Jongstra-Bilen J,Cybulsky MI

更新日期：2016-11-01 00:00:00

abstract：:The origin and specification of human dendritic cells (DCs) have not been investigated at the clonal level. Through the use of clonal assays, combined with statistical computation, to quantify the yield of granulocytes, monocytes, lymphocytes and three subsets of DCs from single human CD34+ progenitor cells, we found ...

journal_title：Nature immunology

authors： Lee J,Zhou YJ,Ma W,Zhang W,Aljoufi A,Luh T,Lucero K,Liang D,Thomsen M,Bhagat G,Shen Y,Liu K

更新日期：2017-08-01 00:00:00

abstract：:The thiol-oxidoreductase ERp57 is an integral component of the peptide-loading complex of the major histocompatibility complex (MHC) class I pathway, but its function is unknown. To investigate its function in antigen presentation, we generated ERp57-deficient mice. Death in utero caused by ubiquitous ERp57 deletion w...

journal_title：Nature immunology

authors： Garbi N,Tanaka S,Momburg F,Hämmerling GJ

更新日期：2006-01-01 00:00:00

abstract：:We define here the specificity and significance of proteases in the endoplasmic reticulum (ER) that generate peptides for presentation by major histocompatibility complex (MHC) class I molecules. We show that aminopeptidases efficiently trimmed all residues except proline that flank the NH2-termini of antigenic precur...

journal_title：Nature immunology

authors： Serwold T,Gaw S,Shastri N

更新日期：2001-07-01 00:00:00

abstract：:Invariant natural killer T cells (iNKT cells) are innate-like lymphocytes that protect against infection, autoimmune disease and cancer. However, little is known about the epigenetic regulation of iNKT cell development. Here we found that the H3K27me3 histone demethylase UTX was an essential cell-intrinsic factor that...

journal_title：Nature immunology

authors： Beyaz S,Kim JH,Pinello L,Xifaras ME,Hu Y,Huang J,Kerenyi MA,Das PP,Barnitz RA,Herault A,Dogum R,Haining WN,Yilmaz ÖH,Passegue E,Yuan GC,Orkin SH,Winau F

更新日期：2017-02-01 00:00:00

abstract：:The mechanisms that initiate T helper type 2 (T(H)2) responses are poorly understood. Here we demonstrate that cysteine protease-induced T(H)2 responses occur via 'cooperation' between migratory dermal dendritic cells (DCs) and basophils positive for interleukin 4 (IL-4). Subcutaneous immunization with papain plus ant...

journal_title：Nature immunology

authors： Tang H,Cao W,Kasturi SP,Ravindran R,Nakaya HI,Kundu K,Murthy N,Kepler TB,Malissen B,Pulendran B

更新日期：2010-07-01 00:00:00

abstract：:Chemokines are chemoattractant proteins that are divided into subfamilies based upon cysteine signature motifs termed C, CC, CXC and CX3C. Chemokines have roles in immunity and inflammation that affect cell trafficking and activation of T cells as well as cells of the innate immune system. We report here CX3C chemokin...

journal_title：Nature immunology

authors： Tripp RA,Jones LP,Haynes LM,Zheng H,Murphy PM,Anderson LJ

更新日期：2001-08-01 00:00:00

abstract：:Innate lymphoid cells (ILCs) are tissue-resident sentinels that are essential for early host protection from pathogens at initial sites of infection. However, whether pathogen-derived antigens directly modulate the responses of tissue-resident ILCs has remained unclear. In the present study, it was found that liver-re...

journal_title：Nature immunology

authors： Weizman OE,Song E,Adams NM,Hildreth AD,Riggan L,Krishna C,Aguilar OA,Leslie CS,Carlyle JR,Sun JC,O'Sullivan TE

更新日期：2019-08-01 00:00:00

abstract：:Although much is known about the migration of T cells from blood to lymph nodes, less is known about the mechanisms regulating the migration of T cells from tissues into lymph nodes through afferent lymphatics. Here we investigated T cell egress from nonlymphoid tissues into afferent lymph in vivo and developed an exp...

journal_title：Nature immunology

authors： Ledgerwood LG,Lal G,Zhang N,Garin A,Esses SJ,Ginhoux F,Merad M,Peche H,Lira SA,Ding Y,Yang Y,He X,Schuchman EH,Allende ML,Ochando JC,Bromberg JS

更新日期：2008-01-01 00:00:00

abstract：:We identified a tumor-associated cytotoxic T lymphocyte (CTL) epitope derived from the widely expressed human MDM2 oncoprotein and were able to bypass self-tolerance to this tumor antigen in HLA-A*0201 (A2.1) transgenic mice and by generating A2.1-negative, allo-A2.1-restricted human T lymphocytes. A broad range of ma...

journal_title：Nature immunology

authors： Stanislawski T,Voss RH,Lotz C,Sadovnikova E,Willemsen RA,Kuball J,Ruppert T,Bolhuis RL,Melief CJ,Huber C,Stauss HJ,Theobald M

更新日期：2001-10-01 00:00:00

abstract：:Dynamic changes in the expression of transcription factors (TFs) can influence the specification of distinct CD8+ T cell fates, but the observation of equivalent expression of TFs among differentially fated precursor cells suggests additional underlying mechanisms. Here we profiled the genome-wide histone modification...

journal_title：Nature immunology

authors： Yu B,Zhang K,Milner JJ,Toma C,Chen R,Scott-Browne JP,Pereira RM,Crotty S,Chang JT,Pipkin ME,Wang W,Goldrath AW

更新日期：2017-05-01 00:00:00

abstract：:After homing to lymph nodes, CD8+ T cells are primed by dendritic cells (DCs) in three phases. During phase one, T cells undergo brief serial contacts with DCs for several hours, whereas phase two is characterized by stable T cell-DC interactions. We show here that the duration of phase one and T cell activation kinet...

journal_title：Nature immunology

authors： Henrickson SE,Mempel TR,Mazo IB,Liu B,Artyomov MN,Zheng H,Peixoto A,Flynn MP,Senman B,Junt T,Wong HC,Chakraborty AK,von Andrian UH

更新日期：2008-03-01 00:00:00

abstract：:DAP12 is a signaling adaptor containing an immunoreceptor tyrosine-based activation motif (ITAM) that pairs with receptors on myeloid cells and natural killer cells. We examine here the responses of mice lacking DAP12 to stimulation through Toll-like receptors (TLRs). Unexpectedly, DAP12-deficient macrophages produced...

journal_title：Nature immunology

authors： Hamerman JA,Tchao NK,Lowell CA,Lanier LL

更新日期：2005-06-01 00:00:00

abstract：:Intestinal microfold cells (M cells) are an enigmatic lineage of intestinal epithelial cells that initiate mucosal immune responses through the uptake and transcytosis of luminal antigens. The mechanisms of M-cell differentiation are poorly understood, as the rarity of these cells has hampered analysis. Exogenous admi...

journal_title：Nature immunology

authors： Kanaya T,Hase K,Takahashi D,Fukuda S,Hoshino K,Sasaki I,Hemmi H,Knoop KA,Kumar N,Sato M,Katsuno T,Yokosuka O,Toyooka K,Nakai K,Sakamoto A,Kitahara Y,Jinnohara T,McSorley SJ,Kaisho T,Williams IR,Ohno H

更新日期：2012-06-17 00:00:00

abstract：:Clinical manifestations of COVID-19 caused by the new coronavirus SARS-CoV-2 are associated with age1,2. Adults develop respiratory symptoms, which can progress to acute respiratory distress syndrome (ARDS) in the most severe form, while children are largely spared from respiratory illness but can develop a life-threa...

journal_title：Nature immunology

authors： Weisberg SP,Connors TJ,Zhu Y,Baldwin MR,Lin WH,Wontakal S,Szabo PA,Wells SB,Dogra P,Gray J,Idzikowski E,Stelitano D,Bovier FT,Davis-Porada J,Matsumoto R,Poon MML,Chait M,Mathieu C,Horvat B,Decimo D,Hudson KE,Zot

更新日期：2021-01-01 00:00:00

abstract：:EAE can refer either to experimental autoimmune encephalomyelitis or experimental allergic encephalomyelitis. Although EAE is classically a prototypic T helper 1 (TH1) cell-mediated autoimmune disease, it can also be induced by TH2 cells. Characteristically, the most severe manifestation of allergy, anaphylaxis, is as...

journal_title：Nature immunology

authors： Pedotti R,Mitchell D,Wedemeyer J,Karpuj M,Chabas D,Hattab EM,Tsai M,Galli SJ,Steinman L

更新日期：2001-03-01 00:00:00

abstract：:Progenitor-like CD8+ T cells mediate long-term immunity to chronic infection and cancer and respond potently to immune checkpoint blockade. These cells share transcriptional regulators with memory precursor cells, including T cell-specific transcription factor 1 (TCF1), but it is unclear whether they adopt distinct pr...

journal_title：Nature immunology

authors： Yao C,Sun HW,Lacey NE,Ji Y,Moseman EA,Shih HY,Heuston EF,Kirby M,Anderson S,Cheng J,Khan O,Handon R,Reilley J,Fioravanti J,Hu J,Gossa S,Wherry EJ,Gattinoni L,McGavern DB,O'Shea JJ,Schwartzberg PL,Wu T

更新日期：2019-07-01 00:00:00

abstract：:Chronic inflammation has been strongly associated with tumor progression, but the underlying mechanisms remain elusive. Here we demonstrate that E3 ligase Itch and deubiquitinase Cyld formed a complex via interaction through 'WW-PPXY' motifs. The Itch-Cyld complex sequentially cleaved Lys63-linked ubiquitin chains and...

journal_title：Nature immunology

authors： Ahmed N,Zeng M,Sinha I,Polin L,Wei WZ,Rathinam C,Flavell R,Massoumi R,Venuprasad K

更新日期：2011-11-06 00:00:00

abstract：:Microbial infections often precede the onset of autoimmunity. How infections trigger autoimmunity remains poorly understood. We investigated the possibility that infection might create conditions that allow the stimulatory presentation of self peptides themselves and that this might suffice to elicit autoreactive T ce...

journal_title：Nature immunology

authors： Campisi L,Barbet G,Ding Y,Esplugues E,Flavell RA,Blander JM

更新日期：2016-09-01 00:00:00

abstract：:CD1 proteins present various glycolipid antigens to T cells, but the cellular mechanisms that control which particular glycolipids generate T cell responses are not understood. We show here that T cell recognition of glucose monomycolate antigens with long (C(80)) alkyl chains involves the delivery of CD1b proteins an...

journal_title：Nature immunology

authors： Moody DB,Briken V,Cheng TY,Roura-Mir C,Guy MR,Geho DH,Tykocinski ML,Besra GS,Porcelli SA

更新日期：2002-05-01 00:00:00