Abstract：
:As a result of decades of research-driven breakthroughs in basic and clinical science and recent advances in the broad-scale implementation of interventions for the prevention and treatment of infection with HIV, a turning point has been reached in the global HIV-AIDS pandemic. To end the pandemic and achieve the goal of an AIDS-free generation, researchers and clinicians must follow the dual pathway of optimizing the implementation of existing prevention and treatment interventions and discovering with basic and clinical research new and effective tools in both of these arenas.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Fauci AS,Folkers GK,Dieffenbach CWdoi
10.1038/ni.2735subject
Has Abstractpub_date
2013-11-01 00:00:00pages
1104-7issue
11eissn
1529-2908issn
1529-2916pii
ni.2735journal_volume
14pub_type
杂志文章abstract：:High-fat diet (HFD) and inflammation are key contributors to insulin resistance and type 2 diabetes (T2D). Interleukin (IL)-1β plays a role in insulin resistance, yet how IL-1β is induced by the fatty acids in an HFD, and how this alters insulin signaling, is unclear. We show that the saturated fatty acid palmitate, b...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.2022
更新日期：2011-05-01 00:00:00
abstract：:The thiol-oxidoreductase ERp57 is an integral component of the peptide-loading complex of the major histocompatibility complex (MHC) class I pathway, but its function is unknown. To investigate its function in antigen presentation, we generated ERp57-deficient mice. Death in utero caused by ubiquitous ERp57 deletion w...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni1288
更新日期：2006-01-01 00:00:00
abstract：:Using both 'reverse genetics' and structural analysis, we have examined the in vivo relationship between antigenicity and T cell receptor (TCR) repertoire diversity. Influenza A virus infection of C57BL/6 mice induces profoundly different TCR repertoires specific for the nucleoprotein peptide of amino acids 366-374 (N...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni1175
更新日期：2005-04-01 00:00:00
abstract：:Newly activated CD8(+) T cells reprogram their metabolism to meet the extraordinary biosynthetic demands of clonal expansion; however, the signals that mediate metabolic reprogramming remain poorly defined. Here we demonstrate an essential role for sterol regulatory element-binding proteins (SREBPs) in the acquisition...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.2570
更新日期：2013-05-01 00:00:00
abstract：:Mucosal surfaces are exposed to environmental substances and represent a major portal of entry for microorganisms. The innate immune system is responsible for early defense against infections and it is believed that the interferons (IFNs) constitute the first line of defense against viruses. Here we identify an innate...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.3319
更新日期：2016-02-01 00:00:00
abstract：: ...
journal_title：Nature immunology
pub_type： 评论,杂志文章
doi：10.1038/s41590-018-0240-x
更新日期：2018-11-01 00:00:00
abstract：:Regulated glycosylation controls T cell processes, including activation, differentiation and homing by creating or masking ligands for endogenous lectins. Here we show that stimuli promoting T helper type 1 (TH1), TH2 or interleukin 17-producing T helper (TH-17) differentiation can differentially regulate the glycosyl...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni1482
更新日期：2007-08-01 00:00:00
abstract：:Oxidants such as H2O2 are connected to lymphocyte activation, but the molecular mechanisms behind this phenomenon are less clear. Here, I review data suggesting that by inhibiting protein tyrosine phosphatases, H2O2 plays an important role as a secondary messenger in the initiation and amplification of signaling at th...
journal_title：Nature immunology
pub_type： 杂志文章,评审
doi：10.1038/ni1202-1129
更新日期：2002-12-01 00:00:00
abstract：:Robert L. Coffman recounts how his work on immunoglobulin E regulation along with data from Tim Mosmann on the functional heterogeneity of T cell clones led to the T helper type 1-T helper type 2 hypothesis. ...
journal_title：Nature immunology
pub_type： 传,历史文章,杂志文章
doi：10.1038/ni0606-539
更新日期：2006-06-01 00:00:00
abstract：:Quantitative mass spectrometry reveals how CD4+ and CD8+ T cells restructure proteomes in response to antigen and mammalian target of rapamycin complex 1 (mTORC1). Analysis of copy numbers per cell of >9,000 proteins provides new understanding of T cell phenotypes, exposing the metabolic and protein synthesis machiner...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/s41590-019-0495-x
更新日期：2019-11-01 00:00:00
abstract：:Programmed cell death is essential for the development and maintenance of cellular homeostasis of the immune system. The Bcl-2 family of proteins comprises both pro-apoptotic and anti-apoptotic members. A subset of pro-apoptotic members, called 'BH3-only' proteins, share sequence homology only in the minimal death dom...
journal_title：Nature immunology
pub_type： 杂志文章,评审
doi：10.1038/ni0503-410
更新日期：2003-05-01 00:00:00
abstract：:Programmed cell death is essential for the development and maintenance of the immune system and its responses to exogenous and endogenous stimuli. Studies have demonstrated that in addition to caspase-dependent apoptosis, necrosis dependent on the kinases RIP1 and RIP3 (also called necroptosis) is a major programmed c...
journal_title：Nature immunology
pub_type： 杂志文章,评审
doi：10.1038/ni.2159
更新日期：2011-11-16 00:00:00
abstract：:Vaccines against important enteric pathogens such as rotavirus and poliovirus have shown lower efficacy in some populations. The application of new technologies and diverse scientific disciplines are needed to realize the promise of truly universal and effective solutions to combat those and other enteric diseases. ...
journal_title：Nature immunology
pub_type：
doi：10.1038/ni0910-769
更新日期：2010-09-01 00:00:00
abstract：:CD46 is a widely expressed transmembrane protein that was initially identified as binding and inactivating C3b and C4b complement products. We used mice that were transgenic for one of two human CD46 isoforms that differ in their cytoplasmic domains (termed CD46-1 and CD46-2) to analyze the effect of CD46 stimulation ...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni810
更新日期：2002-07-01 00:00:00
abstract：:Group 2 innate lymphoid cells (ILC2s) and CD4+ type 2 helper T cells (TH2 cells) are defined by their similar effector cytokines, which together mediate the features of allergic immunity. We found that tissue ILC2s and TH2 cells differentiated independently but shared overlapping effector function programs that were m...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.3582
更新日期：2016-12-01 00:00:00
abstract：:Chemokines facilitate leukocyte migration and positioning as well as other processes such as angiogenesis and leukocyte degranulation. The burgeoning knowledge on chemokines and their receptors has influenced many aspects of immunology, in part because cell migration is intimately related to leukocyte function. This o...
journal_title：Nature immunology
pub_type： 杂志文章,评审
doi：10.1038/84298
更新日期：2001-02-01 00:00:00
abstract：:Despite the prevalence and clinical importance of influenza, its long-term effect on lung immunity is unclear. Here we describe that following viral clearance and clinical recovery, at 1 month after infection with influenza, mice are better protected from Streptococcus pneumoniae infection due to a population of monoc...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/s41590-019-0568-x
更新日期：2020-02-01 00:00:00
abstract：:Immunological memory is thought to be mediated exclusively by lymphocytes. However, enhanced innate immune responses caused by a previous infection increase protection against reinfection, which suggests the presence of innate immunological memory. Here we identified an important role for the stress-response transcrip...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.3257
更新日期：2015-10-01 00:00:00
abstract：:In T lymphocytes, the mitogen-activated protein kinase (MAPK) p38 regulates pleiotropic functions and is activated by canonical MAPK signaling or the alternative activation pathway downstream of the T cell antigen receptor (TCR). Here we found that senescent human T cells lacked the canonical and alternative pathways ...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.2981
更新日期：2014-10-01 00:00:00
abstract：:Current approaches for the treatment of obesity, including diet and lifestyle changes, have not been successful in curtailing the obesity epidemic. The higher incidence of inflammation-associated chronic disease and greater susceptibility to infection in obese people represents a growing health threat. Improved unders...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.2343
更新日期：2012-07-19 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Nature immunology
pub_type： 已发布勘误
doi：10.1038/s41590-019-0554-3
更新日期：2020-01-01 00:00:00
abstract：:CD8+ T cell exhaustion dampens antitumor immunity. Although several transcription factors have been identified that regulate T cell exhaustion, the molecular mechanisms by which CD8+ T cells are triggered to enter an exhausted state remain unclear. Here, we show that interleukin-2 (IL-2) acts as an environmental cue t...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/s41590-020-00850-9
更新日期：2021-01-11 00:00:00
abstract：:The ubiquitin-editing enzyme A20 is a critical negative regulator of inflammation and cytokine-mediated activation of the transcription factor NF-kappaB; however, little is known about the mechanisms of A20-mediated inactivation of signaling intermediates such as RIP1. Here we demonstrate that the regulatory molecule ...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni1563
更新日期：2008-03-01 00:00:00
abstract：:In the version of this article initially published, the Supplementary Note was missing. The Supplementary Note has now been provided online and is cited in the Methods section of the article. The error has been corrected in the HTML and PDF version of the article. ...
journal_title：Nature immunology
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41590-018-0104-4
更新日期：2018-06-01 00:00:00
abstract：:Despite their central function in orchestrating immunity, dendritic cells (DCs) can respond to inhibitory signals by becoming tolerogenic. Here we show that galectin-1, an endogenous glycan-binding protein, can endow DCs with tolerogenic potential. After exposure to galectin-1, DCs acquired an interleukin 27 (IL-27)-d...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.1772
更新日期：2009-09-01 00:00:00
abstract：:The transcription factor c-Myb is expressed throughout T cell development in the thymus. However, little is understood about c-Myb function because of the embryonic lethality of traditional Myb-null mutations. Using tissue-specific deletion to abrogate c-Myb expression at distinct stages of T cell development, we iden...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni1085
更新日期：2004-07-01 00:00:00
abstract：: ...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/s41590-018-0309-6
更新日期：2019-02-01 00:00:00
abstract：:High-throughput 3' single-cell RNA-sequencing (scRNA-seq) allows cost-effective, detailed characterization of individual immune cells from tissues. Current techniques, however, are limited in their ability to elucidate essential immune cell features, including variable sequences of T cell antigen receptors (TCRs) that...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/s41590-019-0544-5
更新日期：2019-12-01 00:00:00
abstract：:Although master transcription factors (TFs) are key to the development of specific T cell subsets, whether additional transcriptional regulators are induced by the same stimuli that dominantly repress the development of other, non-specific T cell lineages has not been fully elucidated. Through the use of regulatory T ...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.3667
更新日期：2017-03-01 00:00:00
abstract：:CD8+ T cells responding to chronic infections or tumors acquire an 'exhausted' state associated with elevated expression of inhibitory receptors, including PD-1, and impaired cytokine production. Exhausted T cells are continuously replenished by T cells with precursor characteristics that self-renew and depend on the ...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/s41590-020-0760-z
更新日期：2020-10-01 00:00:00
