Abstract:
:Plasma cells are cellular factories devoted entirely to the manufacture and export of a single product: soluble immunoglobulin (Ig). As the final mediators of a humoral response, plasma cells play a critical role in adaptive immunity. Although intense effort has been devoted to studying the regulation and requirements for early B cell development, little information has been available on plasma cells. However, more recent work-including studies on genetically altered mice and data from microarray analyses-has begun to identify the regulatory cascades that initiate and maintain the plasma cell phenotype. This review will summarize our current understanding of the molecules that regulate commitment to a plasma cell fate and those that mediate plasma cell function.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Calame KLdoi
10.1038/ni1201-1103keywords:
subject
Has Abstractpub_date
2001-12-01 00:00:00pages
1103-8issue
12eissn
1529-2908issn
1529-2916pii
ni1201-1103journal_volume
2pub_type
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