当前位置： SCI文献检索 > NATURE IMMUNOLOGY期刊下所有文献 > TRADD interacts with STAT1-alpha and influences interferon-gamma signaling.

TRADD interacts with STAT1-alpha and influences interferon-gamma signaling.

Abstract：

:Tumor necrosis factor receptor 1 (TNFR1)-associated death domain protein (TRADD) is essential in recruiting signaling molecules to the TNFR1 receptor complex. Interferon-gamma (IFN-gamma) is a potent activator of macrophages and uses signal transducer and activator of transcription 1-alpha (STAT1-alpha) for signal transduction. Here we demonstrate that IFN-gamma induces the formation of a nuclear-localized TRADD-STAT1-alpha complex. IFN-gamma-mediated STAT1-alpha phosphorylation was prolonged in cells with reduced TRADD expression. Moreover, we noted an increase in IFN-gamma-mediated STAT1-alpha DNA-binding activity, nuclear presence and transcriptional potential in the TRADD knockdown cells. These data indicate that TRADD may be involved in IFN-gamma signaling by forming a complex with STAT1-alpha within the nucleus and regulating IFN-gamma-mediated STAT1-alpha activation.

journal_name

Nat Immunol

journal_title

Nature immunology

authors

Wesemann DR,Qin H,Kokorina N,Benveniste EN

doi

10.1038/ni1025

keywords:

subject

Has Abstract

pub_date

2004-02-01 00:00:00

pages

199-207

issue

2

eissn

1529-2908

issn

1529-2916

pii

ni1025

journal_volume

5

pub_type

杂志文章

相关文献

NATURE IMMUNOLOGY文献大全
  • Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12.

    abstract：:DAP12 is a signaling adaptor containing an immunoreceptor tyrosine-based activation motif (ITAM) that pairs with receptors on myeloid cells and natural killer cells. We examine here the responses of mice lacking DAP12 to stimulation through Toll-like receptors (TLRs). Unexpectedly, DAP12-deficient macrophages produced...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni1204

    authors： Hamerman JA,Tchao NK,Lowell CA,Lanier LL

    更新日期：2005-06-01 00:00:00

  • Apoptosis in response to microbial infection induces autoreactive TH17 cells.

    abstract：:Microbial infections often precede the onset of autoimmunity. How infections trigger autoimmunity remains poorly understood. We investigated the possibility that infection might create conditions that allow the stimulatory presentation of self peptides themselves and that this might suffice to elicit autoreactive T ce...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.3512

    authors： Campisi L,Barbet G,Ding Y,Esplugues E,Flavell RA,Blander JM

    更新日期：2016-09-01 00:00:00

  • Early precursor T cells establish and propagate T cell exhaustion in chronic infection.

    abstract：:CD8+ T cells responding to chronic infections or tumors acquire an 'exhausted' state associated with elevated expression of inhibitory receptors, including PD-1, and impaired cytokine production. Exhausted T cells are continuously replenished by T cells with precursor characteristics that self-renew and depend on the ...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/s41590-020-0760-z

    authors： Utzschneider DT,Gabriel SS,Chisanga D,Gloury R,Gubser PM,Vasanthakumar A,Shi W,Kallies A

    更新日期：2020-10-01 00:00:00

  • A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses.

    abstract：:The family of mammalian Nod-like receptors (NLRs) consists of critical intracellular immune proteins structurally related to plant resistance proteins. The NLRs NALP3 and IPAF, for example, can each form a multiprotein proinflammatory complex called the 'inflammasome', and mutations in the gene encoding Nod2, another ...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni1459

    authors： Mayor A,Martinon F,De Smedt T,Pétrilli V,Tschopp J

    更新日期：2007-05-01 00:00:00

  • Atypical chemokine receptor 1 on nucleated erythroid cells regulates hematopoiesis.

    abstract：:Healthy individuals of African ancestry have neutropenia that has been linked with the variant rs2814778(G) of the gene encoding atypical chemokine receptor 1 (ACKR1). This polymorphism selectively abolishes the expression of ACKR1 in erythroid cells, causing a Duffy-negative phenotype. Here we describe an unexpected ...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.3763

    authors： Duchene J,Novitzky-Basso I,Thiriot A,Casanova-Acebes M,Bianchini M,Etheridge SL,Hub E,Nitz K,Artinger K,Eller K,Caamaño J,Rülicke T,Moss P,Megens RTA,von Andrian UH,Hidalgo A,Weber C,Rot A

    更新日期：2017-07-01 00:00:00

  • Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms.

    abstract：:Bacterial lipopolysaccharide triggers human caspase-4 (murine caspase-11) to cleave gasdermin-D and induce pyroptotic cell death. How lipopolysaccharide sequestered in the membranes of cytosol-invading bacteria activates caspases remains unknown. Here we show that in interferon-γ-stimulated cells guanylate-binding pro...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/s41590-020-0697-2

    authors： Wandel MP,Kim BH,Park ES,Boyle KB,Nayak K,Lagrange B,Herod A,Henry T,Zilbauer M,Rohde J,MacMicking JD,Randow F

    更新日期：2020-08-01 00:00:00

  • Transcriptome networks identify mechanisms of viral and nonviral asthma exacerbations in children.

    abstract：:Respiratory infections are common precursors to asthma exacerbations in children, but molecular immune responses that determine whether and how an infection causes an exacerbation are poorly understood. By using systems-scale network analysis, we identify repertoires of cellular transcriptional pathways that lead to a...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/s41590-019-0347-8

    authors： Altman MC,Gill MA,Whalen E,Babineau DC,Shao B,Liu AH,Jepson B,Gruchalla RS,O'Connor GT,Pongracic JA,Kercsmar CM,Khurana Hershey GK,Zoratti EM,Johnson CC,Teach SJ,Kattan M,Bacharier LB,Beigelman A,Sigelman SM,Presnel

    更新日期：2019-05-01 00:00:00

  • Elevated and sustained expression of the transcription factors Egr1 and Egr2 controls NKT lineage differentiation in response to TCR signaling.

    abstract：:Interactions driven by the T cell antigen receptor (TCR) determine the lineage fate of CD4(+)CD8(+) thymocytes, but the molecular mechanisms that induce the lineage-determining transcription factors are unknown. Here we found that TCR-induced transcription factors Egr2 and Egr1 had higher and more-prolonged expression...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.2230

    authors： Seiler MP,Mathew R,Liszewski MK,Spooner CJ,Barr K,Meng F,Singh H,Bendelac A

    更新日期：2012-02-05 00:00:00

  • Sensing necrosis with Mincle.

    abstract：:The mechanisms that lead to inflammation after necrotic cell death are poorly understood. New data show that the C-type lectin Mincle is involved in this process. ...

    journal_title：Nature immunology

    pub_type： 评论,杂志文章,评审

    doi：10.1038/ni1008-1099

    authors： Brown GD

    更新日期：2008-10-01 00:00:00

  • Hematopoietic progenitor kinase 1 negatively regulates T cell receptor signaling and T cell-mediated immune responses.

    abstract：:HPK1 is a Ste20-related serine-threonine kinase that inducibly associates with the adaptors SLP-76 and Gads after T cell receptor (TCR) signaling. Here, HPK1 deficiency resulted in enhanced TCR-induced phosphorylation of SLP-76, phospholipase C-gamma1 and the kinase Erk, more-persistent calcium flux, and increased pro...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni1416

    authors： Shui JW,Boomer JS,Han J,Xu J,Dement GA,Zhou G,Tan TH

    更新日期：2007-01-01 00:00:00

  • Hydrogen peroxide as second messenger in lymphocyte activation.

    abstract：:Oxidants such as H2O2 are connected to lymphocyte activation, but the molecular mechanisms behind this phenomenon are less clear. Here, I review data suggesting that by inhibiting protein tyrosine phosphatases, H2O2 plays an important role as a secondary messenger in the initiation and amplification of signaling at th...

    journal_title：Nature immunology

    pub_type： 杂志文章,评审

    doi：10.1038/ni1202-1129

    authors： Reth M

    更新日期：2002-12-01 00:00:00

  • Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10.

    abstract：:Despite their central function in orchestrating immunity, dendritic cells (DCs) can respond to inhibitory signals by becoming tolerogenic. Here we show that galectin-1, an endogenous glycan-binding protein, can endow DCs with tolerogenic potential. After exposure to galectin-1, DCs acquired an interleukin 27 (IL-27)-d...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.1772

    authors： Ilarregui JM,Croci DO,Bianco GA,Toscano MA,Salatino M,Vermeulen ME,Geffner JR,Rabinovich GA

    更新日期：2009-09-01 00:00:00

  • Different molecular complexes that mediate transcriptional induction and repression by FoxP3.

    abstract：:FoxP3 conditions the transcriptional signature and functional facets of regulatory T cells (Treg cells). Its mechanism of action, whether as an activator or a repressor, has remained unclear. Here, chromatin analysis showed that FoxP3 bound active enhancer elements, not repressed chromatin, around loci over- or under-...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.3835

    authors： Kwon HK,Chen HM,Mathis D,Benoist C

    更新日期：2017-11-01 00:00:00

  • Transcriptomic and epigenetic mechanisms underlying myeloid diversity in the lung.

    abstract：:The lung is inhabited by resident alveolar and interstitial macrophages as well as monocytic cells that survey lung tissues. Each cell type plays distinct functional roles under homeostatic and inflammatory conditions, but mechanisms establishing their molecular identities and functional potential remain poorly unders...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/s41590-019-0582-z

    authors： Sajti E,Link VM,Ouyang Z,Spann NJ,Westin E,Romanoski CE,Fonseca GJ,Prince LS,Glass CK

    更新日期：2020-02-01 00:00:00

  • Intrusive HIV-1-infected cells.

    abstract：:Macrophages infected with human immunodeficiency virus type 1 emit long intercellular conduits that shuttle the viral protein Nef to bystander B cells, where it impairs cellular function and immunoglobulin class switching. ...

    journal_title：Nature immunology

    pub_type： 新闻

    doi：10.1038/ni0909-933

    authors： Rudnicka D,Schwartz O

    更新日期：2009-09-01 00:00:00

  • Lineage specification of human dendritic cells is marked by IRF8 expression in hematopoietic stem cells and multipotent progenitors.

    abstract：:The origin and specification of human dendritic cells (DCs) have not been investigated at the clonal level. Through the use of clonal assays, combined with statistical computation, to quantify the yield of granulocytes, monocytes, lymphocytes and three subsets of DCs from single human CD34+ progenitor cells, we found ...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.3789

    authors： Lee J,Zhou YJ,Ma W,Zhang W,Aljoufi A,Luh T,Lucero K,Liang D,Thomsen M,Bhagat G,Shen Y,Liu K

    更新日期：2017-08-01 00:00:00

  • IL-1 induces mitochondrial translocation of IRAK2 to suppress oxidative metabolism in adipocytes.

    abstract：:Chronic inflammation is a common feature of obesity, with elevated cytokines such as interleukin-1 (IL-1) in the circulation and tissues. Here, we report an unconventional IL-1R-MyD88-IRAK2-PHB/OPA1 signaling axis that reprograms mitochondrial metabolism in adipocytes to exacerbate obesity. IL-1 induced recruitment of...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/s41590-020-0750-1

    authors： Zhou H,Wang H,Yu M,Schugar RC,Qian W,Tang F,Liu W,Yang H,McDowell RE,Zhao J,Gao J,Dongre A,Carman JA,Yin M,Drazba JA,Dent R,Hine C,Chen YR,Smith JD,Fox PL,Brown JM,Li X

    更新日期：2020-10-01 00:00:00

  • Drosha controls dendritic cell development by cleaving messenger RNAs encoding inhibitors of myelopoiesis.

    abstract：:To investigate if the microRNA (miRNA) pathway is required for dendritic cell (DC) development, we assessed the effect of ablating Drosha and Dicer, the two enzymes central to miRNA biogenesis. We found that while Dicer deficiency had some effect, Drosha deficiency completely halted DC development and halted myelopoie...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.3293

    authors： Johanson TM,Keown AA,Cmero M,Yeo JH,Kumar A,Lew AM,Zhan Y,Chong MM

    更新日期：2015-11-01 00:00:00

  • The histone demethylase UTX regulates the lineage-specific epigenetic program of invariant natural killer T cells.

    abstract：:Invariant natural killer T cells (iNKT cells) are innate-like lymphocytes that protect against infection, autoimmune disease and cancer. However, little is known about the epigenetic regulation of iNKT cell development. Here we found that the H3K27me3 histone demethylase UTX was an essential cell-intrinsic factor that...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.3644

    authors： Beyaz S,Kim JH,Pinello L,Xifaras ME,Hu Y,Huang J,Kerenyi MA,Das PP,Barnitz RA,Herault A,Dogum R,Haining WN,Yilmaz ÖH,Passegue E,Yuan GC,Orkin SH,Winau F

    更新日期：2017-02-01 00:00:00

  • The cytotoxic T cell proteome and its shaping by the kinase mTOR.

    abstract：:We used high-resolution mass spectrometry to map the cytotoxic T lymphocyte (CTL) proteome and the effect of the metabolic checkpoint kinase mTORC1 on CTLs. The CTL proteome was dominated by metabolic regulators and granzymes, and mTORC1 selectively repressed and promoted expression of a subset of CTL proteins (~10%)....

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.3314

    authors： Hukelmann JL,Anderson KE,Sinclair LV,Grzes KM,Murillo AB,Hawkins PT,Stephens LR,Lamond AI,Cantrell DA

    更新日期：2016-01-01 00:00:00

  • The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells.

    abstract：:Intestinal microfold cells (M cells) are an enigmatic lineage of intestinal epithelial cells that initiate mucosal immune responses through the uptake and transcytosis of luminal antigens. The mechanisms of M-cell differentiation are poorly understood, as the rarity of these cells has hampered analysis. Exogenous admi...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.2352

    authors： Kanaya T,Hase K,Takahashi D,Fukuda S,Hoshino K,Sasaki I,Hemmi H,Knoop KA,Kumar N,Sato M,Katsuno T,Yokosuka O,Toyooka K,Nakai K,Sakamoto A,Kitahara Y,Jinnohara T,McSorley SJ,Kaisho T,Williams IR,Ohno H

    更新日期：2012-06-17 00:00:00

  • CSF-1R, DAP12 and beta-catenin: a ménage à trois.

    abstract：:DAP12-coupled receptors influence signals emanating from Toll-like receptors, integrins and receptors for cytokines and growth factors. New findings indicate that DAP12 also facilitates the ability of CSF-1R, the receptor for M-CSF, to induce the stabilization and nuclear translocation of beta-catenin. ...

    journal_title：Nature immunology

    pub_type： 新闻

    doi：10.1038/ni0709-681

    authors： McVicar DW,Trinchieri G

    更新日期：2009-07-01 00:00:00

  • Alarmin S100A11 initiates a chemokine response to the human pathogen Toxoplasma gondii.

    abstract：:Toxoplasma gondii is a common protozoan parasite that infects up to one third of the world's population. Notably, very little is known about innate immune sensing mechanisms for this obligate intracellular parasite by human cells. Here, by applying an unbiased biochemical screening approach, we show that human monocyt...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/s41590-018-0250-8

    authors： Safronova A,Araujo A,Camanzo ET,Moon TJ,Elliott MR,Beiting DP,Yarovinsky F

    更新日期：2019-01-01 00:00:00

  • Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection.

    abstract：:T cell exhaustion has a major role in failure to control chronic infection. High expression of inhibitory receptors, including PD-1, and the inability to sustain functional T cell responses contribute to exhaustion. However, the transcriptional control of these processes remains unclear. Here we demonstrate that the t...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.2046

    authors： Kao C,Oestreich KJ,Paley MA,Crawford A,Angelosanto JM,Ali MA,Intlekofer AM,Boss JM,Reiner SL,Weinmann AS,Wherry EJ

    更新日期：2011-05-29 00:00:00

  • USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation.

    abstract：:Genes and pathways in which inactivation dampens tissue inflammation present new opportunities for understanding the pathogenesis of common human inflammatory diseases, including inflammatory bowel disease, rheumatoid arthritis and multiple sclerosis. We identified a mutation in the gene encoding the deubiquitination ...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni.3581

    authors： Torre S,Polyak MJ,Langlais D,Fodil N,Kennedy JM,Radovanovic I,Berghout J,Leiva-Torres GA,Krawczyk CM,Ilangumaran S,Mossman K,Liang C,Knobeloch KP,Healy LM,Antel J,Arbour N,Prat A,Majewski J,Lathrop M,Vidal SM,Gros

    更新日期：2017-01-01 00:00:00

  • A cis element in the recombination activating gene locus regulates gene expression by counteracting a distant silencer.

    abstract：:We have identified a silencer and an antisilencing element that interact at a distance of 85 kilobases to regulate expression of the recombination activating genes Rag1 and Rag2 in thymocytes. Transgenic experiments showed that Rag promoter-proximal cis elements directed tissue-specific expression and that a Runx-depe...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni1053

    authors： Yannoutsos N,Barreto V,Misulovin Z,Gazumyan A,Yu W,Rajewsky N,Peixoto BR,Eisenreich T,Nussenzweig MC

    更新日期：2004-04-01 00:00:00

  • Remote control of γc expression by arginine methylation.

    abstract：: ...

    journal_title：Nature immunology

    pub_type： 评论,杂志文章

    doi：10.1038/s41590-018-0240-x

    authors： Park JY,Park JH

    更新日期：2018-11-01 00:00:00

  • Deciphering CD4+ T cell specificity using novel MHC-TCR chimeric receptors.

    abstract：:αβ T cell antigen receptors (TCRs) bind complexes of peptide and major histocompatibility complex (pMHC) with low affinity, which poses a considerable challenge for the direct identification of αβ T cell cognate peptides. Here we describe a platform for the discovery of MHC class II epitopes based on the screening of ...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/s41590-019-0335-z

    authors： Kisielow J,Obermair FJ,Kopf M

    更新日期：2019-05-01 00:00:00

  • 53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination.

    abstract：:The mammalian protein 53BP1 is activated in many cell types in response to genotoxic stress, including DNA double-strand breaks (DSBs). We now examine potential functions for 53BP1 in the specific genomic alterations that occur in B lymphocytes. Although 53BP1 was dispensable for V(D)J recombination and somatic hyperm...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni1067

    authors： Manis JP,Morales JC,Xia Z,Kutok JL,Alt FW,Carpenter PB

    更新日期：2004-05-01 00:00:00

  • Patterns of nonclassical MHC antigen presentation.

    abstract：:The identification of pattern-recognition receptors that selectively respond to evolutionarily conserved chemical (often pathogen-derived) moieties has provided key insight into how innate immune cells facilitate rapid and relatively specific antimicrobial immune activity. In contrast, relatively slower adaptive immun...

    journal_title：Nature immunology

    pub_type： 杂志文章

    doi：10.1038/ni1475

    authors： Hansen TH,Huang S,Arnold PL,Fremont DH

    更新日期：2007-06-01 00:00:00