Abstract:
:All complexes of T cell receptors (TCRs) bound to peptide-major histocompatibility complex (pMHC) molecules assume a stereotyped binding 'polarity', despite wide variations in TCR-pMHC docking angles. However, existing TCR-pMHC crystal structures have failed to show broadly conserved pairwise interaction motifs. Here we determined the crystal structures of two TCRs encoded by the variable beta-chain 8.2 (V(beta)8.2), each bound to the MHC class II molecule I-A(u), and did energetic mapping of V(alpha) and V(beta) contacts with I-A(u). Together with two previously solved structures of V(beta)8.2-containing TCR-MHC complexes, we found four TCR-I-A complexes with structurally superimposable interactions between the V(beta) loops and the I-A alpha-helix. This examination of a narrow 'slice' of the TCR-MHC repertoire demonstrates what is probably one of many germline-derived TCR-MHC interaction 'codons'.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Feng D,Bond CJ,Ely LK,Maynard J,Garcia KCdoi
10.1038/ni1502subject
Has Abstractpub_date
2007-09-01 00:00:00pages
975-83issue
9eissn
1529-2908issn
1529-2916pii
ni1502journal_volume
8pub_type
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更新日期:2012-05-20 00:00:00
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更新日期:2019-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2011-11-20 00:00:00
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更新日期:2016-04-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2004-09-01 00:00:00
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更新日期:2008-01-01 00:00:00
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