Abstract:
:In the steady state, dendritic cells (DCs) in the lymph node induce T cell tolerance to self antigens. Innate signals trigger the maturation of tissue DCs, which migrate into lymph nodes and activate T cells. To examine DCs in vivo, we produced transgenic mice whose DCs expressed enhanced yellow fluorescent protein. Two-photon microscopy of lymph nodes in live mice showed that most of the steady-state DCs were enmeshed in an extensive network and remained in place while actively probing adjacent T cells with their processes. Mature DCs were more motile than steady-state DCs and were rapidly dispersed and integrated into the sessile network, facilitating their interaction with migrating T cells.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Lindquist RL,Shakhar G,Dudziak D,Wardemann H,Eisenreich T,Dustin ML,Nussenzweig MCdoi
10.1038/ni1139keywords:
subject
Has Abstractpub_date
2004-12-01 00:00:00pages
1243-50issue
12eissn
1529-2908issn
1529-2916pii
ni1139journal_volume
5pub_type
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