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Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function.

Abstract：

:Phosphoinositide 3-kinase (PI3K) and phosphatase and tensin homolog (PTEN) phosphatase serve essential functions in the regulation of cell growth, differentiation and survival by modulating intracellular phosphatidylinositol-3,4,5-trisphosphate (PI-3,4,5-P3) concentrations. Here we show that the conditional deletion of Pten in B cells led to the preferential generation of marginal zone (MZ) B cells and B1 cells. PTEN-deficient B cells were hyperproliferative in response to mitogenic stimuli, and exhibited a lower threshold for activation through the B cell antigen receptor. Inactivation of PTEN rescued germinal center, MZ B and B1 cell formation in CD19-/- mice, arguing that recruitment and activation of PI3K are the dominant roles for CD19 in these B cell subpopulations. These findings establish the central role of PI-3,4,5-P3 regulation in the differentiation of peripheral B cell subsets.

journal_name

Nat Immunol

journal_title

Nature immunology

authors

Anzelon AN,Wu H,Rickert RC

doi

10.1038/ni892

keywords:

subject

Has Abstract

pub_date

2003-03-01 00:00:00

pages

287-94

issue

3

eissn

1529-2908

issn

1529-2916

pii

ni892

journal_volume

4

pub_type

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