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Environmental allergens induce allergic inflammation through proteolytic maturation of IL-33.

Abstract：

:Allergic inflammation has crucial roles in allergic diseases such as asthma. It is therefore important to understand why and how the immune system responds to allergens. Here we found that full-length interleukin 33 (IL-33FL), an alarmin cytokine with critical roles in type 2 immunity and asthma, functioned as a protease sensor that detected proteolytic activities associated with various environmental allergens across four kingdoms, including fungi, house dust mites, bacteria and pollens. When exposed to allergen proteases, IL-33FL was rapidly cleaved in its central 'sensor' domain, which led to activation of the production of type 2 cytokines in group 2 innate lymphoid cells. Preventing cleavage of IL-33FL reduced allergic airway inflammation. Our findings reveal a molecular mechanism for the rapid induction of allergic type 2 inflammation following allergen exposure, with important implications for allergic diseases.

journal_name

Nat Immunol

journal_title

Nature immunology

authors

Cayrol C,Duval A,Schmitt P,Roga S,Camus M,Stella A,Burlet-Schiltz O,Gonzalez-de-Peredo A,Girard JP

doi

10.1038/s41590-018-0067-5

subject

Has Abstract

pub_date

2018-04-01 00:00:00

pages

375-385

issue

4

eissn

1529-2908

issn

1529-2916

pii

10.1038/s41590-018-0067-5

journal_volume

19

pub_type

杂志文章

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