Abstract:
:
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Visan Idoi
10.1038/s41590-018-0282-0subject
pub_date
2019-01-01 00:00:00pages
1issue
1eissn
1529-2908issn
1529-2916pii
10.1038/s41590-018-0282-0journal_volume
20pub_type
杂志文章abstract::Invariant natural killer T cells (iNKT cells) can produce copious amounts of interleukin 4 (IL-4) early during infection. However, indirect evidence suggests they may produce this immunomodulatory cytokine in the steady state. Through intracellular staining for transcription factors, we have defined three subsets of i...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2731
更新日期:2013-11-01 00:00:00
abstract::Autophagosomes delivers cytoplasmic constituents to lysosomes for degradation, whereas inflammasomes are molecular platforms activated by infection or stress that regulate the activity of caspase-1 and the maturation of interleukin 1β (IL-1β) and IL-18. Here we show that the induction of AIM2 or NLRP3 inflammasomes in...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2215
更新日期:2012-01-29 00:00:00
abstract::Hematopoiesis requires tight regulation of the hematopoietic stem cell (HSC) population; however, the dynamics of HSC use at steady state are uncertain. Over 3-7 months, we evaluated the repopulation and self-renewal of more than 600 individual human 'severe combined immunodeficiency mouse-repopulating cells' (SRCs), ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1393
更新日期:2006-11-01 00:00:00
abstract::CD8(+) T cells eliminate intracellular infections through two contact-dependent effector functions: cytolysis and secretion of antiviral cytokines. Here we identify the following additional function for memory CD8(+) T cells that persist at front-line sites of microbial exposure: to serve as local sensors of previousl...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2568
更新日期:2013-05-01 00:00:00
abstract::Despite the longstanding correlation between transcription and variable-(diversity)-joining (V(D)J) recombination, it is unknown whether transcription itself can direct recombinase targeting. Here we show that blockade of transcriptional elongation through the mouse T cell receptor-alpha (Tcra) locus suppressed V(alph...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1379
更新日期:2006-10-01 00:00:00
abstract::Natural killer (NK) cells have traditionally been considered nonspecific components of innate immunity, but recent studies have shown features of antigen-specific memory in mouse NK cells. However, it has remained unclear whether this phenomenon also exists in primates. We found that splenic and hepatic NK cells from ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3227
更新日期:2015-09-01 00:00:00
abstract::NLRX1 is unique among the nucleotide-binding-domain and leucine-rich-repeat (NLR) proteins in its mitochondrial localization and ability to negatively regulate antiviral innate immunity dependent on the adaptors MAVS and STING. However, some studies have suggested a positive regulatory role for NLRX1 in inducing antiv...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3853
更新日期:2017-12-01 00:00:00
abstract::Using whole-genome microarray data sets of the Immunological Genome Project, we demonstrate a closer transcriptional relationship between NK cells and T cells than between any other leukocytes, distinguished by their shared expression of genes encoding molecules with similar signaling functions. Whereas resting NK cel...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2395
更新日期:2012-10-01 00:00:00
abstract::An important function of receptors that signal through immunoreceptor tyrosine-based activation motifs (ITAMs) is to regulate signaling by heterologous receptors. This review describes mechanisms by which ITAM-associated receptors modulate signaling by Toll-like receptors (TLRs), tumor necrosis factor receptor family ...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni.1706
更新日期:2009-04-01 00:00:00
abstract::Nonmuscle myosin light-chain kinase (MYLK) mediates increased lung vascular endothelial permeability in lipopolysaccharide-induced lung inflammatory injury, the chief cause of the acute respiratory distress syndrome. In a lung injury model, we demonstrate here that MYLK was also essential for neutrophil transmigration...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1628
更新日期:2008-08-01 00:00:00
abstract::The cellular sources of interleukin 6 (IL-6) that are relevant for differentiation of the TH17 subset of helper T cells remain unclear. Here we used a novel strategy for the conditional deletion of distinct IL-6-producing cell types to show that dendritic cells (DCs) positive for the signaling regulator Sirpα were ess...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3632
更新日期:2017-01-01 00:00:00
abstract::Progenitor-like CD8+ T cells mediate long-term immunity to chronic infection and cancer and respond potently to immune checkpoint blockade. These cells share transcriptional regulators with memory precursor cells, including T cell-specific transcription factor 1 (TCF1), but it is unclear whether they adopt distinct pr...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-019-0403-4
更新日期:2019-07-01 00:00:00
abstract::During the productive interaction of T cells with antigen-presenting cells (APCs), engaged receptors, including the T cell antigen receptors and their associated tyrosine kinases, assemble into spatially segregated supramolecular activation clusters (SMACs) at the area of cell contact. Here, we studied intracellular s...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni836
更新日期:2002-10-01 00:00:00
abstract::Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells generated during a large array of pathologic conditions ranging from cancer to obesity. These cells represent a pathologic state of activation of monocytes and relatively immature neutrophils. MDSCs are characterized by a distinct set of ...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/s41590-017-0022-x
更新日期:2018-02-01 00:00:00
abstract:: ...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-018-0247-3
更新日期:2018-11-01 00:00:00
abstract::Immunological memory is thought to be mediated exclusively by lymphocytes. However, enhanced innate immune responses caused by a previous infection increase protection against reinfection, which suggests the presence of innate immunological memory. Here we identified an important role for the stress-response transcrip...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3257
更新日期:2015-10-01 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature immunology
pub_type: 已发布勘误
doi:10.1038/s41590-020-00809-w
更新日期:2020-12-01 00:00:00
abstract::Mycobacterium tuberculosis PtpA, a secreted tyrosine phosphatase essential for tuberculosis pathogenicity, could be an ideal target for a drug against tuberculosis, but its active-site inhibitors lack selectivity over human phosphatases. Here we found that PtpA suppressed innate immunity dependent on pathways of the k...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3096
更新日期:2015-03-01 00:00:00
abstract::The inhibitory signaling of natural killer (NK) cells is crucial in the regulation of innate immune responses. Here we show that the association of KIR2DL1, an inhibitory receptor of NK cells, with beta-arrestin 2 mediated recruitment of the tyrosine phosphatases SHP-1 and SHP-2 to KIR2DL1 and facilitated 'downstream'...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1635
更新日期:2008-08-01 00:00:00
abstract::Immunologists are being compelled to develop new high-dimensional perspectives of cellular heterogeneity and to determine which applications best exploit the power of mass cytometry and associated multiplex approaches. ...
journal_title:Nature immunology
pub_type: 杂志文章,评审
doi:10.1038/ni.3485
更新日期:2016-07-19 00:00:00
abstract::Humoral autoimmunity paralleled by the accumulation of follicular helper T cells (T(FH) cells) is linked to mutation of the gene encoding the RNA-binding protein roquin-1. Here we found that T cells lacking roquin caused pathology in the lung and accumulated as cells of the T(H)17 subset of helper T cells in the lungs...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3008
更新日期:2014-11-01 00:00:00
abstract::After homing to lymph nodes, CD8+ T cells are primed by dendritic cells (DCs) in three phases. During phase one, T cells undergo brief serial contacts with DCs for several hours, whereas phase two is characterized by stable T cell-DC interactions. We show here that the duration of phase one and T cell activation kinet...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1559
更新日期:2008-03-01 00:00:00
abstract::The transcription factor X-box binding protein 1 (XBP-1) is essential for the differentiation of plasma cells and the unfolded protein response (UPR). Here we show that UPR-induced splicing of XBP-1 by the transmembrane endonuclease IRE1 is required to restore production of immunoglobulin in XBP-1-/- mouse B cells, pr...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni907
更新日期:2003-04-01 00:00:00
abstract::Apoptosis signal-regulating kinase 1 (ASK1) is an evolutionarily conserved mitogen-activated protein 3-kinase that activates both Jnk and p38 mitogen-activated protein kinases. Here we used ASK1-deficient mice to show that ASK1 was selectively required for lipopolysaccharide-induced activation of p38 but not of Jnk or...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni1200
更新日期:2005-06-01 00:00:00
abstract::High-dose radiation activates caspases in tumor cells to produce abundant DNA fragments for DNA sensing in antigen-presenting cells, but the intrinsic DNA sensing in tumor cells after radiation is rather limited. Here we demonstrate that irradiated tumor cells hijack caspase 9 signaling to suppress intrinsic DNA sensi...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-020-0641-5
更新日期:2020-05-01 00:00:00
abstract::The final stages of restriction to the T cell lineage occur in the thymus after the entry of thymus-seeding progenitors (TSPs). The identity and lineage potential of TSPs remains unclear. Because the first embryonic TSPs enter a non-vascularized thymic rudiment, we were able to directly image and establish the functio...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.3576
更新日期:2016-12-01 00:00:00
abstract::Nedd4 and Itch are E3 ubiquitin ligases that ubiquitinate similar targets in vitro and thus are thought to function similarly. T cells lacking Itch show spontaneous activation and T helper type 2 polarization. To test whether loss of Nedd4 affects T cells in the same way, we generated Nedd4(+/+) and Nedd4(-/-) fetal l...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1670
更新日期:2008-12-01 00:00:00
abstract::Regulatory T (Treg) cells suppress the development of inflammatory disease, but our knowledge of transcriptional regulators that control this function remains incomplete. Here we show that expression of Id2 and Id3 in Treg cells was required to suppress development of fatal inflammatory disease. We found that T cell a...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.2928
更新日期:2014-08-01 00:00:00
abstract::Toxoplasma gondii is a common protozoan parasite that infects up to one third of the world's population. Notably, very little is known about innate immune sensing mechanisms for this obligate intracellular parasite by human cells. Here, by applying an unbiased biochemical screening approach, we show that human monocyt...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/s41590-018-0250-8
更新日期:2019-01-01 00:00:00
abstract::Type 2 helper T cells (T(H)2) are critically involved in allergies and asthma. Here we demonstrate that extracellular matrix protein-1 (ECM1) is highly and selectively expressed in T(H)2 cells. ECM1 deficiency caused impaired T(H)2 responses and reduced allergic airway inflammation in vivo. Functional analysis demonst...
journal_title:Nature immunology
pub_type: 杂志文章
doi:10.1038/ni.1983
更新日期:2011-02-01 00:00:00