Abstract:
:Despite accumulating evidence that regulatory T cells play a crucial role in preventing autoimmunity, the processes underlying their generation during immune repertoire formation are unknown. We show here that interactions with a single self-peptide can induce thymocytes that bear an autoreactive T cell receptor (TCR) to undergo selection to become CD4+CD25+ regulatory T cells. Selection of CD4+CD25+ thymocytes appears to require a TCR with high affinity for a self peptide because thymocytes that bear TCRs with low affinity do not undergo selection into this pathway. Our findings indicate that specificity for self-peptides directs the selection of CD4+CD25+ regulatory thymocytes by a process that is distinct from positive selection and deletion.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Jordan MS,Boesteanu A,Reed AJ,Petrone AL,Holenbeck AE,Lerman MA,Naji A,Caton AJdoi
10.1038/86302keywords:
subject
Has Abstractpub_date
2001-04-01 00:00:00pages
301-6issue
4eissn
1529-2908issn
1529-2916journal_volume
2pub_type
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