Abstract：
:Biologists, physicians and immunologists have contributed to the understanding of the cellular participants and biological pathways involved in inflammation. Here, we provide a general guide to the cellular and humoral contributors to inflammation as well as to the pathways that characterize inflammation in specific organs and tissues.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Netea MG,Balkwill F,Chonchol M,Cominelli F,Donath MY,Giamarellos-Bourboulis EJ,Golenbock D,Gresnigt MS,Heneka MT,Hoffman HM,Hotchkiss R,Joosten LAB,Kastner DL,Korte M,Latz E,Libby P,Mandrup-Poulsen T,Mantovani A,Millsdoi
10.1038/ni.3790subject
Has Abstractpub_date
2017-07-19 00:00:00pages
826-831issue
8eissn
1529-2908issn
1529-2916pii
ni.3790journal_volume
18pub_type
杂志文章abstract：:Macrophages have protective roles in immunity to pathogens, tissue development, homeostasis and repair following damage. Maladaptive immunity and inflammation provoke changes in macrophage function that are causative of disease. Despite a historical wealth of knowledge about macrophages, recent advances have revealed ...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.3324
更新日期：2016-01-01 00:00:00
abstract：:αβ T cell antigen receptors (TCRs) bind complexes of peptide and major histocompatibility complex (pMHC) with low affinity, which poses a considerable challenge for the direct identification of αβ T cell cognate peptides. Here we describe a platform for the discovery of MHC class II epitopes based on the screening of ...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/s41590-019-0335-z
更新日期：2019-05-01 00:00:00
abstract：:Membrane recruitment of adaptor proteins is crucial for coupling antigen receptors to downstream signaling events. Despite the essential function of the B cell adaptor SLP-65, the mechanism of its recruitment to the plasma membrane is not yet understood. Here we show that a highly conserved leucine zipper in the SLP-6...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni1163
更新日期：2005-02-01 00:00:00
abstract：:CD160, a glycosylphosphatidylinositol-anchored member of the immunoglobulin superfamily, is expressed on both cytolytic lymphocytes and some unstimulated CD4+ T cells. Here we show that CD160 expression was increased after activation of human CD4+ T cells and that crosslinking CD160 with monoclonal antibody strongly i...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni1554
更新日期：2008-02-01 00:00:00
abstract：:Mast cell activation induced by aggregation of Fc epsilon RI receptors with immunoglobulin E and antigen is mediated through the activation of multiple protein kinase cascades. Here we report that the regulatory protein RabGEF1 bound to Ras and negatively regulated Ras activation and its 'downstream' effector pathways...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni1093
更新日期：2004-08-01 00:00:00
abstract：:The ligation of Toll-like receptors (TLRs) leads to rapid activation of dendritic cells (DCs). However, the metabolic requirements that support this process remain poorly defined. We found that DC glycolytic flux increased within minutes of exposure to TLR agonists and that this served an essential role in supporting ...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.2833
更新日期：2014-04-01 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Nature immunology
pub_type： 已发布勘误
doi：10.1038/s41590-019-0476-0
更新日期：2019-10-01 00:00:00
abstract：:Autoreactive B cells have critical roles in a large diversity of autoimmune diseases, but the molecular pathways that control these cells remain poorly understood. We performed an in vivo functional screen of a lymphocyte-expressed microRNA library and identified miR-148a as a potent regulator of B cell tolerance. Ele...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.3385
更新日期：2016-04-01 00:00:00
abstract：:Neutrophils encounter and 'prioritize' many chemoattractants in their pursuit of bacteria. Here we tested the possibility that the phosphatase PTEN is responsible for the prioritization of chemoattractants. Neutrophils induced chemotaxis by two separate pathways, the phosphatidylinositol-3-OH kinase (PI(3)K) phosphata...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.1623
更新日期：2008-07-01 00:00:00
abstract：:Programmed cell death is essential for the development and maintenance of the immune system and its responses to exogenous and endogenous stimuli. Studies have demonstrated that in addition to caspase-dependent apoptosis, necrosis dependent on the kinases RIP1 and RIP3 (also called necroptosis) is a major programmed c...
journal_title：Nature immunology
pub_type： 杂志文章,评审
doi：10.1038/ni.2159
更新日期：2011-11-16 00:00:00
abstract：:The CD4 versus CD8 lineage specification of thymocytes is linked to coreceptor expression. The transcription factor MAZR has been identified as an important regulator of Cd8 expression. Here we show that variegated CD8 expression by loss of Cd8 enhancers was reverted in MAZR-deficient mice, which confirms that MAZR ne...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.1860
更新日期：2010-05-01 00:00:00
abstract：:The extracellular protein Spätzle is required for activation of the Toll signaling pathway in the embryonic development and innate immune defense of Drosophila. Spätzle is synthesized as a pro-protein and is processed to a functional form by a serine protease. We show here that the mature form of Spätzle triggers a To...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni955
更新日期：2003-08-01 00:00:00
abstract：:Invariant natural killer T cells (iNKT cells) can produce copious amounts of interleukin 4 (IL-4) early during infection. However, indirect evidence suggests they may produce this immunomodulatory cytokine in the steady state. Through intracellular staining for transcription factors, we have defined three subsets of i...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.2731
更新日期：2013-11-01 00:00:00
abstract：:The molecular mechanisms directing the development of 'natural' CD4+CD25+Foxp3+ regulatory T cells (T(reg) cells) in the thymus are not thoroughly understood. We show here that conditional deletion of transforming growth factor-beta receptor I (TbetaRI) in T cells blocked the appearance of CD4+CD25+Foxp3+ thymocytes a...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.1607
更新日期：2008-06-01 00:00:00
abstract：: ...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/s41590-018-0309-6
更新日期：2019-02-01 00:00:00
abstract：:HPK1 is a Ste20-related serine-threonine kinase that inducibly associates with the adaptors SLP-76 and Gads after T cell receptor (TCR) signaling. Here, HPK1 deficiency resulted in enhanced TCR-induced phosphorylation of SLP-76, phospholipase C-gamma1 and the kinase Erk, more-persistent calcium flux, and increased pro...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni1416
更新日期：2007-01-01 00:00:00
abstract：:The thiol-oxidoreductase ERp57 is an integral component of the peptide-loading complex of the major histocompatibility complex (MHC) class I pathway, but its function is unknown. To investigate its function in antigen presentation, we generated ERp57-deficient mice. Death in utero caused by ubiquitous ERp57 deletion w...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni1288
更新日期：2006-01-01 00:00:00
abstract：:The human helicase senataxin (SETX) has been linked to the neurodegenerative diseases amyotrophic lateral sclerosis (ALS4) and ataxia with oculomotor apraxia (AOA2). Here we identified a role for SETX in controlling the antiviral response. Cells that had undergone depletion of SETX and SETX-deficient cells derived fro...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.3132
更新日期：2015-05-01 00:00:00
abstract：: ...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/s41590-018-0247-3
更新日期：2018-11-01 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Nature immunology
pub_type： 已发布勘误
doi：10.1038/s41590-019-0545-4
更新日期：2019-12-01 00:00:00
abstract：:CD8(+) T cells eliminate intracellular infections through two contact-dependent effector functions: cytolysis and secretion of antiviral cytokines. Here we identify the following additional function for memory CD8(+) T cells that persist at front-line sites of microbial exposure: to serve as local sensors of previousl...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.2568
更新日期：2013-05-01 00:00:00
abstract：:Plasticity is a hallmark of cells of the myelomonocytic lineage. In response to innate recognition or signals from lymphocyte subsets, mononuclear phagocytes undergo adaptive responses. Shaping of monocyte-macrophage function is an essential component of resistance to pathogens, tissue damage and repair. The orchestra...
journal_title：Nature immunology
pub_type： 杂志文章,评审
doi：10.1038/ni.1937
更新日期：2010-10-01 00:00:00
abstract：:Bacterial lipopolysaccharide triggers human caspase-4 (murine caspase-11) to cleave gasdermin-D and induce pyroptotic cell death. How lipopolysaccharide sequestered in the membranes of cytosol-invading bacteria activates caspases remains unknown. Here we show that in interferon-γ-stimulated cells guanylate-binding pro...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/s41590-020-0697-2
更新日期：2020-08-01 00:00:00
abstract：:The glycolipid alpha-galactosylceramide binds with high affinity to CD1d and stimulates natural killer T cells. Here we report the crystal structure of human CD1d in complex with synthetic alpha-galactosylceramide at a resolution of 3.0 A. The structure shows a tightly fit lipid in the CD1d binding groove, with the sp...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni1225
更新日期：2005-08-01 00:00:00
abstract：:T cell exhaustion has a major role in failure to control chronic infection. High expression of inhibitory receptors, including PD-1, and the inability to sustain functional T cell responses contribute to exhaustion. However, the transcriptional control of these processes remains unclear. Here we demonstrate that the t...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.2046
更新日期：2011-05-29 00:00:00
abstract：:The molecular basis for the propensity of a small number of environmental proteins to provoke allergic responses is largely unknown. Herein, we report that mite group 13 allergens of the fatty acid-binding protein (FABP) family are sensed by an evolutionarily conserved acute-phase protein, serum amyloid A1 (SAA1), tha...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/s41590-020-0698-1
更新日期：2020-07-01 00:00:00
abstract：:In recent years, a population of unconventional T cells called 'mucosal-associated invariant T cells' (MAIT cells) has captured the attention of immunologists and clinicians due to their abundance in humans, their involvement in a broad range of infectious and non-infectious diseases and their unusual specificity for ...
journal_title：Nature immunology
pub_type： 杂志文章,评审
doi：10.1038/s41590-019-0444-8
更新日期：2019-09-01 00:00:00
abstract：:The actin cytoskeleton seems to play two critical roles in the activation of T cells. One of these roles is T cell shape development and movement, including formation of the immunological synapse. The other is the formation of a scaffold for signaling components. This review focuses on the recent convergence of cell b...
journal_title：Nature immunology
pub_type： 杂志文章,评审
doi：10.1038/76877
更新日期：2000-07-01 00:00:00
abstract：:Autophagy is an intracellular bulk degradation system that is highly conserved in eukaryotes. The discovery of autophagy-related ('ATG') proteins in the 1990s greatly advanced the mechanistic understanding of autophagy and clarified the fact that autophagy serves important roles in various biological processes. In add...
journal_title：Nature immunology
pub_type： 杂志文章,评审
doi：10.1038/ni.3273
更新日期：2015-10-01 00:00:00
abstract：:The mechanisms that initiate T helper type 2 (T(H)2) responses are poorly understood. Here we demonstrate that cysteine protease-induced T(H)2 responses occur via 'cooperation' between migratory dermal dendritic cells (DCs) and basophils positive for interleukin 4 (IL-4). Subcutaneous immunization with papain plus ant...
journal_title：Nature immunology
pub_type： 杂志文章
doi：10.1038/ni.1883
更新日期：2010-07-01 00:00:00
