Blimp-1 controls plasma cell function through the regulation of immunoglobulin secretion and the unfolded protein response.

Abstract:

:Plasma cell differentiation requires silencing of B cell transcription, while it establishes antibody-secretory function and long-term survival. The transcription factors Blimp-1 and IRF4 are essential for the generation of plasma cells; however, their function in mature plasma cells has remained elusive. We found that while IRF4 was essential for the survival of plasma cells, Blimp-1 was dispensable for this. Blimp-1-deficient plasma cells retained their transcriptional identity but lost the ability to secrete antibody. Blimp-1 regulated many components of the unfolded protein response (UPR), including XBP-1 and ATF6. The overlap in the functions of Blimp-1 and XBP-1 was restricted to that response, with Blimp-1 uniquely regulating activity of the kinase mTOR and the size of plasma cells. Thus, Blimp-1 was required for the unique physiological ability of plasma cells that enables the secretion of protective antibody.

journal_name

Nat Immunol

journal_title

Nature immunology

authors

Tellier J,Shi W,Minnich M,Liao Y,Crawford S,Smyth GK,Kallies A,Busslinger M,Nutt SL

doi

10.1038/ni.3348

subject

Has Abstract

pub_date

2016-03-01 00:00:00

pages

323-30

issue

3

eissn

1529-2908

issn

1529-2916

pii

ni.3348

journal_volume

17

pub_type

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