Abstract:
:Plasma cell differentiation requires silencing of B cell transcription, while it establishes antibody-secretory function and long-term survival. The transcription factors Blimp-1 and IRF4 are essential for the generation of plasma cells; however, their function in mature plasma cells has remained elusive. We found that while IRF4 was essential for the survival of plasma cells, Blimp-1 was dispensable for this. Blimp-1-deficient plasma cells retained their transcriptional identity but lost the ability to secrete antibody. Blimp-1 regulated many components of the unfolded protein response (UPR), including XBP-1 and ATF6. The overlap in the functions of Blimp-1 and XBP-1 was restricted to that response, with Blimp-1 uniquely regulating activity of the kinase mTOR and the size of plasma cells. Thus, Blimp-1 was required for the unique physiological ability of plasma cells that enables the secretion of protective antibody.
journal_name
Nat Immunoljournal_title
Nature immunologyauthors
Tellier J,Shi W,Minnich M,Liao Y,Crawford S,Smyth GK,Kallies A,Busslinger M,Nutt SLdoi
10.1038/ni.3348subject
Has Abstractpub_date
2016-03-01 00:00:00pages
323-30issue
3eissn
1529-2908issn
1529-2916pii
ni.3348journal_volume
17pub_type
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