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Metabolic pressure and the breach of immunological self-tolerance.

Abstract：

:The prevalence of autoimmune disorders in affluent countries has reached epidemic proportions. Over the past 50 years, a reverse trend between the frequency of infectious diseases and the incidence of autoimmune and allergic diseases led to the so-called 'hygiene hypothesis'. Given the epidemiological evidence and recent experimental data, we propose that this concept should also include metabolic pressure secondary to exposure to excessive daily caloric intake and overnutrition. We discuss how metabolic workload can modulate immunological tolerance and review the molecular mechanisms and the state of the art of the field. We also critically evaluate possibilities for restoring immunological homeostasis under conditions of metabolic pressure.

journal_name

Nat Immunol

journal_title

Nature immunology

authors

De Rosa V,La Cava A,Matarese G

doi

10.1038/ni.3851

subject

Has Abstract

pub_date

2017-10-18 00:00:00

pages

1190-1196

issue

11

eissn

1529-2908

issn

1529-2916

pii

ni.3851

journal_volume

18

pub_type

杂志文章

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