High prevalence of adeno-associated virus (AAV) type 2 rep DNA in cervical materials: AAV may be sexually transmitted.

Abstract:

:Adeno-associated virus (AAV) is a human parvovirus that in laboratory and animal models has the ability to suppress the oncogenic phenotype of a variety of viruses and cellular derived oncogenes. The inhibitory effects of AAV have been mapped to its rap gene (Rep78 protein). Furthermore, seroepidemiologic data indicate that AAV infection is linked to reduced cervical cancer rates in humans. Because of AAV's inverse relationship with cervical cancer, we attempted to identify AAV rep sequences within DNA derived from cervical brushings taken from nondiseased middle class patients at a Little Rock clinic. Polymerase chain reaction (PCR) amplification was carried out with primers designed to amplify a specific segment of the endogenous human beta-globin gene or the AAV rep gene. Of those cervical samples that were positive for beta-globin DNA, 50% were also found to be positive for AAV rep DNA when analyzed by either ethidium bromide staining or dot-blot hybridization with an internal probe. These data strongly suggest that AAV is commonly carried in the genital region and further raise the possibility that AAV can be sexually transmitted.

journal_name

Virus Genes

journal_title

Virus genes

authors

Han L,Parmley TH,Keith S,Kozlowski KJ,Smith LJ,Hermonat PL

doi

10.1007/BF00370000

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

47-52

issue

1

eissn

0920-8569

issn

1572-994X

journal_volume

12

pub_type

杂志文章
  • Molecular evidence for the existence of two distinct subgroups in cucumber mosaic cucumovirus.

    abstract::Infectious full-length cDNA clones from the genomic RNAs of a subgroup II cucumber mosaic cucumovirus strain (Trk7) were obtained. Sequence analysis of the whole genome revealed strong homology (99%) to the genome of Q-CMV, the only subgroup II strain whose entire genomic nucleotide sequence had been available in the ...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1023/a:1008016202128

    authors: Szilassy D,Salánki K,Balázs E

    更新日期:1999-01-01 00:00:00

  • Cleavage of transcripts of foot and mouth disease virus (FMDV), Asia1 serotype, by ribozymes targeted to the VP3 and VP4 genes.

    abstract::Two ribozyme genes were designed to cut within the VP4 and VP3 sequences of foot and mouth disease virus (FMDV) Asia1 serotype genome. The two genes were synthesized and cloned into pBluescript under the control of the T3 promoter. The ribozyme designed to cut the VP4 gene contained two catalytic sequences targeted to...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1007/BF01702658

    authors: Stram Y,Molad T

    更新日期:1995-01-01 00:00:00

  • Comparison of hepatitis B X gene mutation between patients with hepatocellular carcinoma and patients with chronic hepatitis B.

    abstract::Hepatitis B virus (HBV), a major causative agent of hepatocellular carcinoma (HCC), encodes an oncogenic X protein (HBx) that transcriptionally activates multiple viral and cellular promoters. The present study aimed to identify the specific gene mutation related to the clinical outcome of HCC. Seventy-two HBV-infecte...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1007/s11262-010-0557-5

    authors: Fan W,Shi B,Wei H,Du G,Song S

    更新日期:2011-04-01 00:00:00

  • Influenza A viruses: why focusing on M2e-based universal vaccines.

    abstract::The threat of highly virulent avian influenza, such as H5N1 and swine-origin H1N1 influenza viruses, bring out an urgent need to develop a universal influenza vaccine, which may provide cross-protection against different strain of influenza A viruses. The extra-domain of influenza M2 protein (M2e), which is almost com...

    journal_title:Virus genes

    pub_type: 杂志文章,评审

    doi:10.1007/s11262-010-0547-7

    authors: Ebrahimi SM,Tebianian M

    更新日期:2011-02-01 00:00:00

  • Phylogenetic analysis of NS5B gene of classical swine fever virus isolates indicates plausible Chinese origin of Indian subgroup 2.2 viruses.

    abstract::Twenty-three CSFV isolates recovered from field outbreaks in various parts of India during 2006-2009 were used for genetic analysis in the NS5B region (409 nts). Seventeen of these were studied earlier [16] in the 5'UTR region. Phylogenetic analysis indicated the continued dominance of subgroup 1.1 strains in the coun...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1007/s11262-011-0572-1

    authors: Patil SS,Hemadri D,Veeresh H,Sreekala K,Gajendragad MR,Prabhudas K

    更新日期:2012-02-01 00:00:00

  • Genetic analysis of H3 subtype influenza viruses isolated from domestic ducks in northern China during 2004-2005.

    abstract::The broad distribution and prevalence of H3 subtype influenza viruses in avian and mammalian hosts constitutes a global threat to both human and veterinary health. In this present study, six H3N8 influenza viruses isolated from domestic ducks during 2004-2005 in northern China were genetically and phylogenetically cha...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1007/s11262-008-0300-7

    authors: Pu J,Liu QF,Xia YJ,Fan YL,Brown EG,Tian FL,Liu JH

    更新日期:2009-02-01 00:00:00

  • Analysis of codon usage in Newcastle disease virus.

    abstract::In this study, the relative synonymous codon usage (RSCU) values, effective number of codon (ENC) values, nucleotide contents, and dinucleotide were used to investigate codon usage pattern of each protein-coding gene and genome among 31 Newcastle disease virus (NDV) isolates. The result shows that the overall extent o...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1007/s11262-011-0574-z

    authors: Wang M,Liu YS,Zhou JH,Chen HT,Ma LN,Ding YZ,Liu WQ,Gu YX,Zhang J

    更新日期:2011-04-01 00:00:00

  • Characterization of an early gene (wsv477) from shrimp white spot syndrome virus (WSSV).

    abstract::White spot syndrome virus (WSSV) is one of the most virulent pathogens causing high mortality in shrimp. The viral early genes play a key role in DNA replication and virus proliferation. In this study, a WSSV gene (wsv477) encoding 208 amino acid peptides was characterized as an early gene. The temporal analysis showe...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1007/s11262-006-0053-0

    authors: Han F,Xu J,Zhang X

    更新日期:2007-04-01 00:00:00

  • Heptad-repeat sequences in the glycoprotein of rhabdoviruses.

    abstract::Two or three regions containing three or more successive newly defined heptads of a-d hydrophobic amino acid repeats have been located in the cDNA-derived amino acid sequences of glycoprotein G of all rhabdoviruses examined (rabies, vesicular stomatitis, fish, and plant rhabdoviruses) by computer search. These new hep...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1007/BF01702591

    authors: Coll JM

    更新日期:1995-01-01 00:00:00

  • Complete nucleotide sequence of a mumps virus genotype I strain isolated in Korea.

    abstract::The complete nucleotide sequence of mumps virus isolated in Korea, Dg1062/Korea/98 (Dg1062), was determined. As other mumps viruses, its genome was to be 15,384 nucleotides (nts) in length and encoded seven proteins. The both 5' and 3' ends were confirmed to be 55 and 24 nts by RACE method, respectively. The full-leng...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1023/B:VIRU.0000016859.04203.88

    authors: Lee JY,Na BK,Lee HD,Chang SW,Kim KA,Kim JH,Cho HW,Kim J,Kang C

    更新日期:2004-03-01 00:00:00

  • The N-terminus of vaccinia virus host range protein C7L is essential for function.

    abstract::Vaccinia virus (VACV), a member of the Poxviridae family of large double-stranded DNA viruses, is being used as a smallpox vaccine as well as an expression vector for immunization against other infectious diseases and cancer. The host range of wild type VACV is very broad among mammalian cells. C7L is a host range gen...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1007/s11262-012-0822-x

    authors: Terajima M,Urban SL,Leporati AM

    更新日期:2013-02-01 00:00:00

  • Cervical cancer-causing human papillomaviruses have an alternative initiation site for the L1 protein.

    abstract::All known sequences of the DNA encoding the major cervical cancer-causing human papillomavirus type 16 (HPV16) L1 capsid protein contain initiation codons which would allow translation to begin at either nucleotide 5559 or 5637. However the formation of virus-like particles (VLPs) only occurs efficiently when the init...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1007/s11262-004-4579-8

    authors: Webb E,Cox J,Edwards S

    更新日期:2005-01-01 00:00:00

  • Identification and characterization of a novel Tritimovirus species isolated from wild Trisetum flavescens L., family Poaceae.

    abstract::Yellow oat-grass plants (Trisetum flavescens L.) with mild mosaic and pronounced dwarfing symptoms were observed at different locations in the Czech Republic. Electron microscope observations of symptomatic plants revealed the presence of filamentous particles and inclusion bodies characteristic of the family Potyviri...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1007/s11262-009-0373-y

    authors: Hassan M,Sirlova L,Jokes M,Vacke J

    更新日期:2009-08-01 00:00:00

  • Variations in the nucleocapsid protein gene of infectious bronchitis viruses isolated in Korea.

    abstract::Fourteen infectious bronchitis viruses (IBVs) were isolated in Korea between 2001 and 2003 from chickens suspected to be infected with IBVs. The nucleocapsid (N) protein genes of the various IBVs were amplified by reverse transcriptase-polymerase chain reaction (RT-PCR) and were cloned and sequenced, and the nucleotid...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1007/s11262-005-1788-8

    authors: Park JY,Pak SI,Sung HW,Kim JH,Song CS,Lee CW,Kwon HM

    更新日期:2005-10-01 00:00:00

  • Genetic diversity of Sugarcane bacilliform virus isolates infecting Saccharum spp. in India.

    abstract::Sugarcane bacilliform virus (SCBV), which causes leaf freckle in sugarcane, is a member of the genus Badnavirus. Studies were conducted to characterize SCBV in Saccharum officinarum germplasm and cultivated varieties in India by sequencing the complete genomes of five isolates. Genome lengths ranged from 7,553 to 7,88...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1007/s11262-013-0890-6

    authors: Karuppaiah R,Viswanathan R,Kumar VG

    更新日期:2013-06-01 00:00:00

  • Sequencing, phylogenetic analysis, and potential recombination events of infectious bronchitis viruses isolated in Korea.

    abstract::The S2 glycoprotein and membrane (M) protein genes and S1 glycoprotein and nucleocapsid (N) genes of 11 Korean infectious bronchitis virus (IBV) isolates were amplified by RT-PCR, cloned, and sequenced. The resultant nucleotide sequences were compared with the published sequences for non-Korean IBV strains. Korean IBV...

    journal_title:Virus genes

    pub_type: 信件

    doi:10.1007/s11262-012-0856-0

    authors: Song JE,Jeong WG,Sung HW,Kwon HM

    更新日期:2013-04-01 00:00:00

  • Nucleotide sequence of the capsid protein gene of potato virus Y (PVY).

    abstract::The nucleotide sequence of the 3' terminal region of potato virus Y (PVY) was determined. Starting with a poly(A) tail of 18 residues a non-coding region of 335 nucleotides precedes the region encoding for the virus coat protein (cp) 801 nucleotides long ending with a TGA. This region was located by comparing the pred...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1007/BF00572704

    authors: Rosner A,Raccah B

    更新日期:1988-06-01 00:00:00

  • Characterisation of a satellite RNA of Cucumber mosaic virus that induces chlorosis in Capsicum annuum.

    abstract::The presence of Cucumber mosaic virus (CMV) satellite RNA dramatically changes symptoms on some hosts. A satellite RNA present in a strain of CMV (PepY-CMV) that induced chlorosis in pepper (Capsicum annuum) was shown to induce chlorosis in pepper in combination with another strain (Fny-CMV) that by itself induced a g...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1007/s11262-011-0608-6

    authors: Choi SK,Jeon YW,Yoon JY,Choi JK

    更新日期:2011-08-01 00:00:00

  • A short insert in the leader sequence of RNA 3L, a long variant of Alfalfa mosaic virus RNA3, introduces two unidentified reading frames.

    abstract::N20-RNA 3L, a large form of RNA 3 associated with Alfalfa mosaic virus (AMV) strain N20 comprises 2281 nt and has approximately 97% overall sequence similarity to the longest previously described RNA 3 of AMV strain YSMV (YSMV-RNA 3; 2188 nt). Compared with YSMV-RNA 3, N20-RNA 3L contains an additional 97 nt in the 5'...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1007/s11262-004-7433-0

    authors: Jayasena KW,Randles JW

    更新日期:2004-12-01 00:00:00

  • Molecular cloning and characterization of retrovirus-like intracisternal type A particle genes (IAP) present in the Chinese hamster genome.

    abstract::Endogenous retrovirus-like sequences that are homologous to the multigenic murine and Syrian hamster intracisternal type A particle (IAP) genes can be detected in very few copies in the Chinese hamster (CH) genome. They were cloned from a CHO gene library and two recombinants, harboring the major IAP-like DNA genes ch...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1007/BF00570029

    authors: Servenay M,Kupiec JJ,Peries J,Emanoil-Ravier R

    更新日期:1990-12-01 00:00:00

  • Interaction between Translocation-associated membrane protein 1 and σC protein of novel duck reovirus controls virus infectivity.

    abstract::Novel duck reovirus (NDRV), the prototype strain of the species Avian orthoreovirus (ARV), is associated with high mortality in Pekin ducklings. σC is an outer capsid protein encoded by the S1 genome segment of NDRV which mediates attachment to host cells. Our previous studies using immunoprecipitation and mass spectr...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1007/s11262-020-01750-8

    authors: Xiao R,Mi X,Sun J,Ding M,Li C,Zhu J,Liu G,Ma W,Zhou H,Chen Z

    更新日期:2020-06-01 00:00:00

  • Hamster polyomavirus-derived virus-like particles are able to transfer in vitro encapsidated plasmid DNA to mammalian cells.

    abstract::The authentic major capsid protein 1 (VP1) of hamster polyomavirus (HaPyV) consists of 384 amino acid (aa) residues (42 kDa). Expression from an additional in-frame initiation codon located upstream from the authentic VP1 open reading frame (at position -4) might result in the synthesis of a 388 aa-long, amino-termina...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1007/s11262-006-0028-1

    authors: Voronkova T,Kazaks A,Ose V,Ozel M,Scherneck S,Pumpens P,Ulrich R

    更新日期:2007-06-01 00:00:00

  • Origin and evolution of viroids and viroid-like satellite RNAs.

    abstract::Viroids, the smallest and simplest agents of infectious disease, cause a number of economically important diseases of crop plants. Present evidence indicates that most of these diseases originated recently (in the 20th century) by chance transfer of viroids from endemically infected wild plants or by use of viroid-inf...

    journal_title:Virus genes

    pub_type: 杂志文章,评审

    doi:10.1007/BF01728653

    authors: Diener TO

    更新日期:1995-01-01 00:00:00

  • Phylogenetic analysis of hemagglutinin and neuraminidase genes of H9N2 viruses isolated from migratory ducks.

    abstract::Genetic analysis indicated that the pandemic influenza strains derived from wild aquatic birds harbor viruses of 15 hemagglutinin (HA) and 9 neuraminidase (NA) antigenic subtypes. Surveillance studies have shown that H9N2 subtype viruses are worldwide in domestic poultry and could infect mammalian species, including h...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1023/a:1026304117797

    authors: Liu JH,Okazaki K,Shi WM,Kida H

    更新日期:2003-12-01 00:00:00

  • Genomic sequence analysis of the Illinois strain of the Agrotis ipsilon multiple nucleopolyhedrovirus.

    abstract::The Agrotis ipsilon multiple nucleopolyhedrovirus (AgipMNPV) is a group II nucleopolyhedrovirus (NPV) from the black cutworm, A. ipsilon, with potential as a biopesticide to control infestations of cutworm larvae. The genome of the Illinois strain of AgipMNPV was completely sequenced. The AgipMNPV genome was 155,122 n...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1007/s11262-008-0297-y

    authors: Harrison RL

    更新日期:2009-02-01 00:00:00

  • The evolution of small DNA viruses of eukaryotes: past and present considerations.

    abstract::Historically, viral evolution has often been considered from the perspective of the ability of the virus to maintain viral pathogenic fitness by causing disease. A predator-prey model has been successfully applied to explain genetically variable quasi-species of viruses, such as influenza virus and human immunodeficie...

    journal_title:Virus genes

    pub_type: 杂志文章,评审

    doi:10.1007/BF01728663

    authors: Shadan FF,Villarreal LP

    更新日期:1995-01-01 00:00:00

  • Complete nucleotide sequence of the rice tungro spherical virus genome of the highly virulent strain Vt6.

    abstract::The complete nucleotide sequence of rice tungro spherical virus (RTSV) strain Vt6, originally from Mindanao, the Philippines, with higher virulence to resistant rice cultivars, was determined and compared with the published sequence for the Philippine-type strain A (RTSV-A-Shen). It was reported that RTSV-A was not ab...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1023/a:1008116408733

    authors: Isogai M,Cabauatan PQ,Masuta C,Uyeda I,Azzam O

    更新日期:2000-01-01 00:00:00

  • Genetic mechanisms of antigenic variation in infectious bursal disease virus: analysis of a naturally occurring variant virus.

    abstract::The major immunogenic protein VP2 from a pathogenic field isolate (variant A virus) of infectious bursal disease virus (IBDV) was cloned and sequenced to examine antigenic variations. The VP2 open reading frame consists of 1509 nucleotides and codes for a 503 amino acid protein. Overall, the VP2 amino acid sequence of...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1007/BF01702563

    authors: Lana DP,Beisel CE,Silva RF

    更新日期:1992-08-01 00:00:00

  • Complete nucleotide sequence, genome organization and phylogenic analysis of the canine calicivirus.

    abstract::The complete genomic sequence of canine calicivirus (CaCV) isolated from feces of a dog with diarrhea was determined. The CaCV genome, a positive-sense single-stranded RNA, contained 8513 nucleotides excluding the poly(A) tail and was longer than that of any other calicivirus strain with a completely known sequence. T...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1023/a:1020174225622

    authors: Matsuura Y,Tohya Y,Nakamura K,Shimojima M,Roerink F,Mochizuki M,Takase K,Akashi H,Sugimura T

    更新日期:2002-01-01 00:00:00

  • A sensitive duplex nanoparticle-assisted PCR assay for identifying porcine epidemic diarrhea virus and porcine transmissible gastroenteritis virus from clinical specimens.

    abstract::In this study, a novel duplex nanoparticle-assisted polymerase chain reaction (nanoPCR) assay was developed to detect porcine epidemic diarrhea virus (PEDV) and porcine transmissible gastroenteritis virus (TGEV). Two pairs of primers were designed based on the conserved region within the N gene of PEDV and TGEV. In a ...

    journal_title:Virus genes

    pub_type: 杂志文章

    doi:10.1007/s11262-016-1405-z

    authors: Zhu Y,Liang L,Luo Y,Wang G,Wang C,Cui Y,Ai X,Cui S

    更新日期:2017-02-01 00:00:00