Recombinant lentivirus-delivered short hairpin RNAs targeted to conserved coxsackievirus sequences protect against viral myocarditis and improve survival rate in an animal model.

abstract：:Currently, virus-based vectors, namely derivatives of the adenovirus, are frequently used in a wide variety of ex vivo or local gene therapeutic applications. However, the efficacy of virus-based vectors in systemic applications is presently still extremely limited. Complex interactions of the various vector types wit...

journal_title：Virus genes

authors： Jönsson F,Kreppel F

更新日期：2017-10-01 00:00:00

abstract：:Base usage and dinucleotide frequency have been extensively studied in many eukaryotic organisms and bacteria, but not for viruses. In this paper, a comprehensive analysis of these aspects for infectious bursal disease virus (IBDV) was presented. The analysis of base usage indicated that all of the IBDV genes possess ...

journal_title：Virus genes

authors： Tan DY,Hair Bejo M,Aini I,Omar AR,Goh YM

更新日期：2004-01-01 00:00:00

abstract：:The near-complete (99.7 %) genome sequence of a novel Russian Plum pox virus (PPV) isolate Pk, belonging to the strain Winona (W), has been determined by 454 pyrosequencing with the exception of the thirty-one 5'-terminal nucleotides. This region was amplified using 5'RACE kit and sequenced by the Sanger method. Genom...

journal_title：Virus genes

authors： Sheveleva A,Kudryavtseva A,Speranskaya A,Belenikin M,Melnikova N,Chirkov S

更新日期：2013-10-01 00:00:00

abstract：:The immunity of a combined DNA vaccine of HSV-2 glycoproteins B2 (gB2) and D2 (gD2) genes in comparison to individual vaccines was studied with regard to protecting against the HSV infection. Two recombinant DNA vaccines of the pHS2-gB2 or pHS2-gD2 were constructed and formulated. The neutralizing antibody titers appe...

journal_title：Virus genes

authors： Lee HH,Cha SC,Jang DJ,Lee JK,Choo DW,Kim YS,Uh HS,Kim SY

更新日期：2002-10-01 00:00:00

abstract：:For millions of years viruses have adapted strategies to interfere with the immune defense of the host, which in turn has to deal with this challenge. In general the antiviral defense remains one step behind the pathogen. To achieve this strategic advantage large DNA-containing Viruses encode cellular homologues that ...

journal_title：Virus genes

authors： Raftery M,Müller A,Schönrich G

更新日期：2000-01-01 00:00:00

abstract：:Glycosylation on the globular head of the hemagglutinin (HA) protein of influenza virus acts as an important target for recognition and destruction of virus by innate immune proteins of the collectin family. In the current study, we have characterized the dynamic amino acid changes at N-linked glycosylation sites of f...

journal_title：Virus genes

authors： El Moussi A,Ben Hadj Kacem MA,Slim A

更新日期：2014-02-01 00:00:00

abstract：:The biological diversity within viruses is one of the largest found in all other forms of nature. Many mechanisms contribute to virus diversity and include incorporating genetic material from the host, recombination between viruses belonging to the same or to a different family, and even recombination between viruses ...

journal_title：Virus genes

authors： Davidson I,Silva RF

更新日期：2008-02-01 00:00:00

abstract：:Tomato mosaic virus (ToMV), a member of the genus Tobamovirus, infects several ornamental and horticultural crops worldwide. In this study, the nucleotide sequences of the coat protein gene of worldwide ToMV isolates were analyzed to estimate the genetic structure and diversity of this virus and the involved evolution...

journal_title：Virus genes

authors： Rangel EA,Alfaro-Fernández A,Font-San-Ambrosio MI,Luis-Arteaga M,Rubio L

更新日期：2011-12-01 00:00:00

abstract：:Human parainfluenza virus type 3 (HPIV3) causes the majority of childhood viral pneumonia around the world. Fusing the viral and target cell membranes is crucial for its entry into target cells, and the fusion process requires the concerted actions of two viral glycoproteins: hemagglutinin-neuraminidase (HN) and fusio...

journal_title：Virus genes

authors： Liu Y,Chi M,Wen H,Zhao L,Song Y,Liu N,Chi L,Wang Z

更新日期：2020-02-01 00:00:00

abstract：:The Tahyna virus (TAHV) is an important human pathogen in the Bunyaviridae family. To date, only the S and M segments of this virus have been sequenced, but the sequence of the L segment hasn't been established yet. In this study, we sequenced 963 nucleotides of the L segment of TAHV, comprising pre-motif A and motif ...

journal_title：Virus genes

authors： Quinan BR,de Brito Magalhães CL,Novaes RF,Dos Santos JR,Kroon EG,Bonjardim CA,Ferreira PC

更新日期：2008-06-01 00:00:00

abstract：:The intraspecies variability of capsid proteins of five viruses of the genus Comovirus was established. Inclusion of both capsid proteins to the sequence analysis reduces some uncertainties about species/strains demarcation criteria in the Comovirus genus. New approach is proposed for discrimination of Turnip ringspot...

journal_title：Virus genes

authors： Petrzik K,Koloniuk I

更新日期：2010-04-01 00:00:00

abstract：:Recent studies have shown that dual mutations in fp25K and p35 of Autographa californica nucleopolyhedrovirus (AcMNPV) result in a typical apoptotic infection on Trichoplusia ni cells, suggesting the involvement of FP25K on NPV-induced apoptosis. To examine the effect of fp25K deletion on Bombyx mori NPV (BmNPV)-induc...

journal_title：Virus genes

authors： Nakanishi T,Shimada T,Katsuma S

更新日期：2010-08-01 00:00:00

abstract：:The thymidylate synthase (TS, EC 2.1.1.45) is essential for the de novo synthesis of dTMP in pro- and eucaryotic organisms. Consequently it plays a major role in the replication of the DNA genome of a cell or a DNA virus. The gene encoding the TS of Chilo iridescent virus (CIV) was identified by nucleotide sequence an...

journal_title：Virus genes

authors： Müller K,Tidona CA,Bahr U,Darai G

更新日期：1998-01-01 00:00:00

abstract：:Papillomaviruses are small and complex viruses with circular DNA genome that belongs to the Papillomavirus family, which comprises at least 39 genera. The bovine papillomavirus (BPV) causes an infectious disease that is characterized by chronic and proliferative benign tumors that affect cattle worldwide. In the prese...

journal_title：Virus genes

authors： da Silva FR,Daudt C,Cibulski SP,Weber MN,Varela AP,Mayer FQ,Roehe PM,Canal CW

更新日期：2017-02-01 00:00:00

abstract：:Amino acid and phylogenetic analysis showed that PB1-F2 of H7N7 and H3N8 equine influenza virus (EIV) evolved into two and nine clades, respectively. The PB1-F2 gene of H7N7 EIV strains isolated after 1973 was identified as being replaced by that of H3N8 EIV circulating simultaneously. All H7N7 EIV strains before 1973...

journal_title：Virus genes

authors： Lu G,Guo W,Qi T,Ma J,Zhao S,Tian Z,Pan J,Zhu C,Wang X,Xiang W

更新日期：2013-10-01 00:00:00

abstract：:Vaccinia virus (VACV), a member of the Poxviridae family of large double-stranded DNA viruses, is being used as a smallpox vaccine as well as an expression vector for immunization against other infectious diseases and cancer. The host range of wild type VACV is very broad among mammalian cells. C7L is a host range gen...

journal_title：Virus genes

authors： Terajima M,Urban SL,Leporati AM

更新日期：2013-02-01 00:00:00

abstract：:Genetic diversity of eight Grapevine leafroll-associated virus 1 (GLRaV-1) isolates recovered from grapevines in three distinct locations in the Czech Republic and Slovakia was characterised by restriction fragment length polymorphism (RFLP) analysis and by sequencing of cloned 540 bp fragment of the heat shock protei...

journal_title：Virus genes

authors： Komínek P,Glasa M,Bryxiová M

更新日期：2005-12-01 00:00:00

abstract：:Bovine viral diarrhea virus (BVDV) belongs to the Pestivirus genus of the Flaviviridae family and has worldwide distribution, being one of the main causes of economic losses in cattle raising. The genome of pestiviruses is a single strand of positive-sense RNA with a length of 12.3 kb, which encodes one open reading f...

journal_title：Virus genes

authors： Mirosław P,Polak MP

更新日期：2020-08-01 00:00:00

abstract：:Staphylococcus aureus is a well-known pathogen that causes several serious diseases in humans and animals. As part of the efforts to control this pathogen, a newly isolated bacteriophage, SA12, which specifically targets S. aureus, was characterized, and its genome was completely sequenced. Host range and bacteriophag...

journal_title：Virus genes

authors： Chang Y,Lee JH,Shin H,Heu S,Ryu S

更新日期：2013-10-01 00:00:00

abstract：:Jaagsiekte sheep retrovirus (JSRV) is the causative agent of ovine pulmonary adenocarcinoma (OPA), a contagious lung cancer in sheep. Previous studies have shown that the JSRV envelope protein (Env) functions as an oncogene, in that it can morphologically transform rodent fibroblast and epithelial cell lines. To obtai...

journal_title：Virus genes

authors： Dakessian RM,Inoshima Y,Fan H

更新日期：2007-08-01 00:00:00

abstract：:Two cucumber mosaic virus (CMV) isolates XJ1 and XJ2 were obtained from sugar beet showing yellow mosaic symptom in Shihezi, Xinjiang Uigur municipality of China. The coat protein gene of the two CMV isolates and their associated satellite RNAs were amplified by reverse transcriptase polymerase chain reaction (RT-PCR)...

journal_title：Virus genes

authors： Xi D,Lan L,Wang J,Xu W,Xiang B,Lin H

更新日期：2006-12-01 00:00:00

abstract：:Protein 2A is a non-structural protein of coxsackievirus B3 (CVB3), an important human pathogen that can cause a variety of human diseases. Protein 2A not only participates in viral life cycle, but also regulates host cell functions; however, the underlying mechanisms remain poorly understood. In order to better under...

journal_title：Virus genes

authors： Zhao T,Huang X,Xia Y

更新日期：2016-04-01 00:00:00

abstract：:DNA fragments containing the secretory glycoprotein A (gA) gene of Marek's disease virus type 1 (MDV1) were cloned from the DNA libraries of very virulent Md5 and virulent BC-1 strains and sequenced. Two open reading frames (ORF1 and ORF2) were identified for both strains. The ORF1 has the potential to code for a prot...

journal_title：Virus genes

authors： Ihara T,Kato A,Ueda S,Ishihama A,Hirai K

更新日期：1989-11-01 00:00:00

abstract：:The main function of baculoviral chitinase protein (V-CHIA) is to promote the final liquefaction of infected host larvae, facilitating the dispersion of occlusion bodies (OBs) in the environment. In this study, a v-chiA from Epinotia aporema Granulovirus (EpapGV) was identified and characterized. The 1,713 base pairs ...

journal_title：Virus genes

authors： Salvador R,Ferrelli ML,Sciocco-Cap A,Romanowski V

更新日期：2014-04-01 00:00:00

abstract：:We evaluated the predicted biochemical properties of Gag proteins from a diverse group of feline immunodeficiency viruses (FIV) to determine how different evolutionary histories of virus and host have changed or constrained these important structural proteins. Our data are based on FIV sequences derived from domestic ...

journal_title：Virus genes

authors： Burkala E,Poss M

更新日期：2007-10-01 00:00:00

abstract：:Japanese encephalitis (JE), which is a mosquito-borne arboviral infection, is the leading cause of viral encephalitis in Asian countries. The causative agent of JE is Japanese encephalitis virus (JEV), in which the predominant genotype has changed from genotype III (G III) to genotype I (G I). However, a method for th...

journal_title：Virus genes

authors： Zhang L,Cao S,Wu R,Zhu S,Liu H,Yuan L,Shi S,Zhang D,Huang X,Wen X,Wen Y,Yan Q,Huang Y,Ma X

更新日期：2015-04-01 00:00:00

abstract：:Cap-independent translations of viral RNAs of enteroviruses and rhinoviruses, cardioviruses and aphthoviruses, hepatitis A and C viruses (HAV and HCV), and pestivirus are initiated by the direct binding of 40S ribosomal subunits to a cis-acting genetic element termed the internal ribosome entry site (IRES) or ribosome...

journal_title：Virus genes

authors： Le SY,Siddiqui A,Maizel JV Jr

更新日期：1996-01-01 00:00:00

abstract：:Pneumonia virus of mice (PVM) is an enveloped RNA-containing virus of Family Paramyxoviridae. Sequences had been determined previously for a number of PVM genes, although these represented cloned cDNAs rather than consensus sequences. Sequences were not available for the 3' -leader and 5' -trailer regions that constit...

journal_title：Virus genes

authors： Krempl CD,Lamirande EW,Collins PL

更新日期：2005-03-01 00:00:00

abstract：:The previous study of the 25 hemagglutinin-esterase (HE) glycoprotein genes of influenza C viruses identified four discrete lineages represented by C/Yamagata/26/81, C/Aichi/1/81, C/Aomori/74 and C/Mississippi/80, respectively. Here we compared the M gene sequence among the 24 viruses isolated between 1964 and 1991. A...

journal_title：Virus genes

authors： Tada Y,Hongo S,Muraki Y,Sugawara K,Kitame F,Nakamura K

更新日期：1997-01-01 00:00:00

abstract：:Viroids, the smallest and simplest agents of infectious disease, cause a number of economically important diseases of crop plants. Present evidence indicates that most of these diseases originated recently (in the 20th century) by chance transfer of viroids from endemically infected wild plants or by use of viroid-inf...

journal_title：Virus genes

authors： Diener TO

更新日期：1995-01-01 00:00:00