Abstract:
:Vaccinia virus (VACV), a member of the Poxviridae family of large double-stranded DNA viruses, is being used as a smallpox vaccine as well as an expression vector for immunization against other infectious diseases and cancer. The host range of wild type VACV is very broad among mammalian cells. C7L is a host range gene identified in VACV and is well conserved in mammalian poxviruses except for parapoxviruses and molluscum contagiosum virus. The molecular mechanisms by which the C7L gene exerts host range function are not well understood. The C7L protein does not have any known conserved domains or show sequence similarity to cellular proteins or viral proteins other than the C7L homologs in mammalian poxviruses. We generated recombinant vaccinia viruses carrying deletion mutants of the C7L gene using NYVAC as a parental strain and found that the N-terminus is essential for host range function of C7L, which is consistent with a previous report that showed that homology among C7L homologs are greater near the N-terminus than the C-terminus.
journal_name
Virus Genesjournal_title
Virus genesauthors
Terajima M,Urban SL,Leporati AMdoi
10.1007/s11262-012-0822-xsubject
Has Abstractpub_date
2013-02-01 00:00:00pages
20-7issue
1eissn
0920-8569issn
1572-994Xjournal_volume
46pub_type
杂志文章相关文献
VIRUS GENES文献大全abstract::Twenty-four avian influenza viruses were collected from poultry farms in three different governorates in Egypt during the years 2006-2009 and genetically characterized. All the isolates were confirmed to be type A and subtype H5 influenza virus by chromatographic strip test and hemagglutination inhibition assay. The s...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-011-0633-5
更新日期:2011-10-01 00:00:00
abstract::Newcastle disease virus with velogenic characteristics circulates in the poultry industry in Mexico and various other American countries. In Mexico, vaccine efficacy testing to obtain commercial registration is reliant on a challenge with a velogenic strain known colloquially as Chimalhuacan due to the site where it w...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-014-1082-8
更新日期:2014-10-01 00:00:00
abstract::During October 2014, unfamiliar mild mosaic and mottling symptoms were identified on leaves of pepper (Capsicum chinense cv. Habanero) seedlings grown in the Arava valley in Israel 2-3 weeks post planting. Symptomatic plants were tested positive by ELISA using laboratory-produced antisera for tobamovirus species. Typi...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-018-1539-2
更新日期:2018-04-01 00:00:00
abstract::A novel fluorescent probe-based real-time reverse transcription recombinase polymerase amplification (real-time RT-RPA) assay was developed for rapid detection of highly pathogenic type 2 porcine reproductive and respiratory syndrome virus (HP-PRRSV). The sensitivity analysis showed that the detection limit of RPA was...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-016-1378-y
更新日期:2016-12-01 00:00:00
abstract::Avian reovirus infection causes considerable economic loss to the commercial poultry industry. Live-attenuated vaccine strain S1133 (v-S1133, derived from parent strain S1133) is considered the safest and most effective vaccine and is currently used worldwide. To identify the genes responsible for its attenuation, DNA...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-013-1029-5
更新日期:2014-04-01 00:00:00
abstract::The complete nucleotide sequences of neuraminidase (NA) of two swine influenza viruses (H1N1) are presented. A/Sw/Quebec/5393/91 (SwQc91) virus, associated with the chronic respiratory disease and A/Sw/ Quebec/192/81 (SwQc81) virus, associated with the acute respiratory disease, were used. The deduced amino acid seque...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1023/a:1007944228967
更新日期:1997-01-01 00:00:00
abstract::We have examined sequence variability among nine isolates of hop stunt viroid (HSVd) collected from hop gardens in Tohoku district in Japan, the only area in the world where hop stunt disease is endemic. Six different consensus and one-consensus sequences as well as 12 sequence variants were detected in the nine HSVd-...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1023/a:1008182302704
更新日期:2001-01-01 00:00:00
abstract::Typically associated with fungal species, members of the viral family Totiviridae have recently been shown to be associated with plants, including important crop species, such as Carica papaya (papaya) and Zea mays (maize). Maize-associated totivirus (MATV) was first described in China and more recently in Ecuador, wh...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-019-01650-6
更新日期:2019-06-01 00:00:00
abstract::Porcine reproductive and respiratory syndrome (PRRS) is a swine disease of major economic importance that causes reproductive and respiratory problems in pigs. In the present study, one strain of porcine reproductive and respiratory syndrome virus (PRRSV) was isolated in Xinjiang province, Northwest China, designated ...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-014-1122-4
更新日期:2015-02-01 00:00:00
abstract::By using a phage vector (lambda ZAP II) and the mRNA extracted from IMR-32 cells infected with the RC.HL strain of rabies virus, we constructed a cDNA library from which four nucleoprotein (N)-specific cDNA clones were obtained by Southern blot hybridization. These clones contained a cDNA insert of about 1.4 kb, in wh...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/BF01703607
更新日期:1994-03-01 00:00:00
abstract::The expression of geminivirus genes is controlled by bidirectional promoters which are located in the large intergenic region of the circular DNA genomes and specifically regulated by virus encoded proteins. In order to study the simultaneous regulation of both orientations of the DNA A and DNA B promoters of African ...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1023/a:1008183827072
更新日期:2001-03-01 00:00:00
abstract::The major immunogenic protein VP2 from a pathogenic field isolate (variant A virus) of infectious bursal disease virus (IBDV) was cloned and sequenced to examine antigenic variations. The VP2 open reading frame consists of 1509 nucleotides and codes for a 503 amino acid protein. Overall, the VP2 amino acid sequence of...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/BF01702563
更新日期:1992-08-01 00:00:00
abstract::Foot-and-mouth disease (FMD) is the most contagious and devastating disease of livestock. Our previous studies demonstrated that TK(-)/gG(-)/P1(+), a recombinant expressing the FMDV capsid precursor protein (P1) based on attenuated pseudorabies virus (PRV) TK(-)/gG(-), could be used as a recombinant vaccine to protect...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-008-0204-6
更新日期:2008-04-01 00:00:00
abstract::Orf virus (ORFV) strain D1701-V, a Parapoxvirus belonging to the family Poxviridae, became attractive as a novel virus vector system that we successfully used for the generation of recombinant vaccines. Therefore, the identification of viral genes involved in host tropisms or immune modulation is of great interest, as...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-014-1069-5
更新日期:2014-08-01 00:00:00
abstract::The original version of this article unfortunately contained errors in the "Results" section. ...
journal_title:Virus genes
pub_type: 已发布勘误
doi:10.1007/s11262-019-01662-2
更新日期:2019-06-01 00:00:00
abstract::Ramu stunt disease of sugarcane was first reported in Papua New Guinea in the mid 1980s. The disease can reduce sugarcane yields significantly and causes severe stunting and mortality in highly susceptible cultivars. The causal agent of Ramu stunt has been investigated but its characterization has not been completed. ...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-015-1279-5
更新日期:2016-02-01 00:00:00
abstract::Exfoliative toxin A (ETA)-coding temperate bacteriophages are leading contributors to the toxic phenotype of impetigo strains of Staphylococcus aureus. Two distinct eta gene-positive bacteriophages isolated from S. aureus strains which recently caused massive outbreaks of pemphigus neonatorum in Czech maternity hospit...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-015-1223-8
更新日期:2015-08-01 00:00:00
abstract::Dengue virus (DENV) is an arthropod-borne human pathogen that represents a severe public health threat in both endemic and non-endemic regions. So far, there is no licensed vaccine or specific drugs available for dengue fever. A fifteen-amino-acid-long peptide that includes the NGR motif was chemically synthesized and...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-017-1508-1
更新日期:2018-02-01 00:00:00
abstract::The antigenic variation in Foot and Mouth Disease Virus (FMDV) is very high. The effective strategy to control the Foot and Mouth Disease (FMD) in India which is a habitat of four serotypes O, A, C and Asia 1, is by regular vaccination, using the vaccine strain most suitable for the local situation. India is an endemi...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1023/a:1007984621839
更新日期:1997-01-01 00:00:00
abstract::Korean field infectious bursal disease viruses (IBDVs) were isolated from IBDV suspected commercial chickens. A previous study revealed that these IBDV field isolates were virulent or very virulent IBDVs. The isolates were passaged three times in the chorioallantoic membrane of specific-pathogen-free embryonated chick...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1023/b:viru.0000025776.52661.b0
更新日期:2004-04-01 00:00:00
abstract::Porcine epidemic diarrhea virus (PEDV) causes a devastating enteric disease with acute diarrhea, dehydration and significant mortality in swine, thereby incurring heavy economic losses in Korea. Spike (S) glycoprotein has been suggested as an important determinant for PEDV biological properties. In this study, the nuc...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-007-0096-x
更新日期:2007-10-01 00:00:00
abstract::A BK virus isolate cloned from the urine of an immunosuppressed patient was identified as the WW strain. Fine mapping using four base-pair restriction enzymes identified a number of small deletions and insertions relative to prototype BK. The finding of a transcriptional control region with a structure similar to that...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/BF00315259
更新日期:1989-03-01 00:00:00
abstract::Porcine reproductive and respiratory syndrome (PRRS) is considered to be one of the most important infectious diseases affecting livestock. This study used gene sequence analysis of ORF5 and Nsp2 to determine the molecular epidemiology of PRRSV in different parts of the Guangxi province of China. These genes were sele...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-012-0824-8
更新日期:2013-02-01 00:00:00
abstract::The establishment of viral pathogens in new host environments following spillover events probably requires adaptive changes within both the new host and pathogen. After many generations, signals for ancient cross-species transmission may become lost and a strictly host-adapted phylogeny may mimic true co-divergence wh...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-019-01702-x
更新日期:2019-12-01 00:00:00
abstract::Pseudorabies virus (PRV) belongs to the Alphaherpesvirinae subfamily of Herpesviridae. PRV-induced pseudorabies is a highly contagious disease that has caused huge economic losses to the global swine industry. The PRV gE/gI gene deletion vaccine strain (Fa ΔgE/gI strain) constructed from the PRV Fa wild-type strain wa...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-020-01760-6
更新日期:2020-08-01 00:00:00
abstract::Sacbrood virus (SBV) represents a serious threat to the health of managed honeybees. We determined four complete SBV genomic sequences (AmSBV-Kor1, AmSBV-Kor2, AcSBV-Kor3, and AcSBV-Kor4) isolated from Apis mellifera and Apis cerana in various regions of South Korea. A phylogenetic tree was constructed from the comple...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-015-1268-8
更新日期:2016-04-01 00:00:00
abstract::Boid inclusion body disease (BIBD) is a viral disease of boids caused by reptarenavirus. In this study, tissue from naturally infected boid snakes were homogenized and propagated in African Monkey kidney (Vero) and rat embryonic fibroblast (REF) cells. Virus replication was determined by the presence of cytopathic eff...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-016-1345-7
更新日期:2016-10-01 00:00:00
abstract::Cell mediated immunity (CMI) is crucial for the defense against viruses. Cytotoxic T lymphocytes (CTLs) play a major role in CMI. They recognize endogenous antigenic peptides presented by antigen presenting cells in association with the major histocompatibility complex (MHC) class I molecules. The elucidation of the s...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1023/a:1007913216861
更新日期:1997-01-01 00:00:00
abstract::Varicella-zoster virus (VZV) DNA was detectable by in-situ hybridization in blood mononuclear cells (MNCs) of patients with varicella or zoster for 2-56 days after the onset of a rash. VZV DNA was present in many MNCs from one acute varicella patient 2 days after the onset of the rash and was rarely found in MNCs duri...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/BF00684037
更新日期:1989-08-01 00:00:00
abstract::Mal de Río Cuarto virus (MRCV) is a newly described species of the genus Fijivirus, family Reoviridae. Compared with other plant-infecting genus of the family, the function and localization of MRCV and other Fijivirus proteins are poorly understood. Through analysis of viral particle purifications, we positively ident...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-009-0345-2
更新日期:2009-06-01 00:00:00