Abstract:
:Recent studies have shown that dual mutations in fp25K and p35 of Autographa californica nucleopolyhedrovirus (AcMNPV) result in a typical apoptotic infection on Trichoplusia ni cells, suggesting the involvement of FP25K on NPV-induced apoptosis. To examine the effect of fp25K deletion on Bombyx mori NPV (BmNPV)-induced apoptosis, we generated a BmNPV mutant, fp-p35D, in which both fp25K and p35 genes are deleted from the genome, and compared its phenotype with wild-type (T3), fp25K-deleted (fp-null), and p35-deleted (p35D) BmNPVs. In BmN cells, p35D, but not T3 or fp-null, caused apoptosis with caspase-3 activation. Infection with fp-p35D also resulted in caspase-3 activation, but the level was comparable to that of p35D. Also, we did not observe any apoptotic responses in hemocytes from larvae infected with p35D or fp-p35D. These results indicate that unlike AcMNPV, deletion of fp25K does not affect the pathway of p35D-induced apoptosis of BmN cells and B. mori larvae.
journal_name
Virus Genesjournal_title
Virus genesauthors
Nakanishi T,Shimada T,Katsuma Sdoi
10.1007/s11262-010-0492-5subject
Has Abstractpub_date
2010-08-01 00:00:00pages
144-8issue
1eissn
0920-8569issn
1572-994Xjournal_volume
41pub_type
杂志文章相关文献
VIRUS GENES文献大全abstract::Vaccinia virus (VACV), a member of the Poxviridae family of large double-stranded DNA viruses, is being used as a smallpox vaccine as well as an expression vector for immunization against other infectious diseases and cancer. The host range of wild type VACV is very broad among mammalian cells. C7L is a host range gen...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-012-0822-x
更新日期:2013-02-01 00:00:00
abstract::Proteins harbor domains or short linear motifs, which facilitate their functions and interactions. Finding functional motifs in protein sequences could predict the putative cellular roles or characteristics of hypothetical proteins. In this study, we present Shetti-Motif, which is an interactive tool to (i) map UniPro...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-016-1416-9
更新日期:2017-04-01 00:00:00
abstract::Nine avian influenza viruses (AIV), H5N1 subtype, were isolated from dead poultry in the Karachi region of Pakistan from 2006 to 2008. The intravenous pathogenicity indices and HA protein cleavage sites of all nine viruses were consistent with highly pathogenic AIV. Based on phylogenetic analysis of the HA genes, thes...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-011-0689-2
更新日期:2012-04-01 00:00:00
abstract::Acinetobacter pittii is an important pathogen causing nosocomial infection worldwide. In this study, a multidrug-resistant A. pittii ABC38 was used as host bacterium to isolate the lytic phage vB_ApiP_XC38. The biological characteristics of vB_ApiP_XC38 were studied and the genome was sequenced and analyzed. vB_ApiP_X...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-020-01766-0
更新日期:2020-08-01 00:00:00
abstract::We have determined the 5' and 3' non-coding regions (NCR) of four dengue-2 viruses isolated from dengue patients with different clinical severities in Nakhon Phanom, Northeastern Thailand in 1993. The results were compared to prototype dengue-2 strains and were found to have highest homology with the New Guinea C stra...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1023/a:1007914520454
更新日期:1997-01-01 00:00:00
abstract::Hepatitis C virus (HCV) infection is a major global health issue. Although the search for HCV treatments has resulted in great achievements, the current treatment methods have limitations, and new methods and drugs for hepatitis C treatment are still required. The aim of the present study was to investigate the effect...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-015-1285-7
更新日期:2016-02-01 00:00:00
abstract::Rice tungro spherical virus (RTSV) was shown to have three coat protein (CP) species by high resolution NaDodSO4-PAGE and Western blot analyses. The sequence of a coat protein-expressing cDNA clone that was identified and selected from a RTSV cDNA library showed that the insert was composed of 2823 bp with only one la...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/BF01702392
更新日期:1993-06-01 00:00:00
abstract::To determine the prevalence of TT virus (TTV) and GB virus C/hepatitis G virus (GBV-C) infections among patients with liver disease and the general population in Shanghai, China, we studied 90 patients with liver diseases (acute hepatitis, 28; chronic hepatitis, 27; liver cirrhosis, 20; hepatocellular carcinoma, 15) a...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1023/a:1008188623062
更新日期:1999-01-01 00:00:00
abstract::During October 2014, unfamiliar mild mosaic and mottling symptoms were identified on leaves of pepper (Capsicum chinense cv. Habanero) seedlings grown in the Arava valley in Israel 2-3 weeks post planting. Symptomatic plants were tested positive by ELISA using laboratory-produced antisera for tobamovirus species. Typi...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-018-1539-2
更新日期:2018-04-01 00:00:00
abstract::The simian virus 40 (SV40) large T antigen is a 708 amino-acid protein possessing multiple biochemical activities that play distinct roles in productive infection or virus-induced cell transformation. The carboxy-terminal portion of T antigen includes a domain that carries the nucleotide binding and ATPase activities ...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1023/a:1007941622680
更新日期:1998-01-01 00:00:00
abstract::The authentic major capsid protein 1 (VP1) of hamster polyomavirus (HaPyV) consists of 384 amino acid (aa) residues (42 kDa). Expression from an additional in-frame initiation codon located upstream from the authentic VP1 open reading frame (at position -4) might result in the synthesis of a 388 aa-long, amino-termina...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-006-0028-1
更新日期:2007-06-01 00:00:00
abstract::The complete genomic sequence of canine calicivirus (CaCV) isolated from feces of a dog with diarrhea was determined. The CaCV genome, a positive-sense single-stranded RNA, contained 8513 nucleotides excluding the poly(A) tail and was longer than that of any other calicivirus strain with a completely known sequence. T...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1023/a:1020174225622
更新日期:2002-01-01 00:00:00
abstract::Seed-transmitted viruses have caused significant damage to watermelon crops in Korea in recent years, with cucumber green mottle mosaic virus (CGMMV) infection widespread as a result of infected seed lots. To determine the likely origin of CGMMV infection, we collected CGMMV isolates from watermelon and melon fields a...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-016-1415-x
更新日期:2017-04-01 00:00:00
abstract::Torque teno viruses (TTVs) are classified into the Anellovirus genus of the Circoviridae family. In addition to TTV isolates, TTV genogroup 3 also includes the 8 virus strains known as SENV-A to H. In this study, the prevalence of TTV group 3 viruses and that of SENV-D and H in particular were determined among the sta...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-009-0369-7
更新日期:2009-08-01 00:00:00
abstract::Base usage and dinucleotide frequency have been extensively studied in many eukaryotic organisms and bacteria, but not for viruses. In this paper, a comprehensive analysis of these aspects for infectious bursal disease virus (IBDV) was presented. The analysis of base usage indicated that all of the IBDV genes possess ...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1023/B:VIRU.0000012262.89898.c7
更新日期:2004-01-01 00:00:00
abstract::Although Sapovirus (Caliciviridae) has been accepted as one of the causes of acute gastroenteritis worldwide, little is known about the genetic characteristics of the whole genome of sapoviruses in China, especially those that infect humans. Here we report the complete genome sequence of a sapovirus strain, Human/Zhej...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-016-1343-9
更新日期:2016-10-01 00:00:00
abstract::The highly pathogenic Bombyx mori nucleopolyhedrovirus (BmNPV) has caused severe damages to sericulture in many countries, and the relationship between the pathogenicity of various BmNPV strains and their geographical evolution has been the topic of our interest. In this study, we isolated a new BmNPV strain from Thai...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-012-0721-1
更新日期:2012-06-01 00:00:00
abstract::DNA viruses as their host cells require a DNA-dependent DNA polymerase (Pol) to faithfully replicate their genomic information. Large eukaryotic DNA viruses as well as bacterial viruses encode a specific Pol equipped with a proofreading 3'-5'-exonuclease, and other replication proteins. All known viral Pol belong to f...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1023/a:1007997609122
更新日期:1998-01-01 00:00:00
abstract::Despite the vast distribution and expansive diversity of enteroviruses reported globally, indicators defining a complete view of the epidemiology of enteroviruses in tropical countries such as the Philippines are yet to be established. Detection of enteroviruses in the environment has been one of the markers of circul...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-012-0776-z
更新日期:2012-10-01 00:00:00
abstract::Tobacco bushy top disease is caused by tobacco bushy top virus (TBTV, a member of the genus Umbravirus) which is dependent on tobacco vein-distorting virus (TVDV) to act as a helper virus encapsidating TBTV and enabling its transmission by aphids. Isometric virions from diseased tobacco plants were purified and diseas...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-010-0524-1
更新日期:2010-12-01 00:00:00
abstract::The genomic diversity of Argentine Tospoviruses from different geographical areas, and from several distinct crops was analysed here. For each isolate, RT-PCR, cloning and sequencing of a 450 nt fragment of the N gene were performed. Comparisons of RNA and predicted amino acid sequence identity and similarity were mad...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/BF00366986
更新日期:1996-01-01 00:00:00
abstract::The nucleic acid and deduced amino acid sequence of the fibre gene of the HNF-61 strain of porcine adenovirus serotype 5 (PAdV-5) was determined and compared to that of the HNF-70 strain of the same serotype (Nagy et al., J Gen Virol 82, 525-529, 2001) and also to adenovirus fibre genes from the genera Mastadenovirus ...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1023/a:1014580802250
更新日期:2002-03-01 00:00:00
abstract::We describe the isolation and characterization of an insect-specific flavivirus (ISF) from Ochlerotatus caspius (Pallas, 1771) mosquitoes collected in southern Portugal. The RNA genome of this virus, tentatively designated OCFVPT, for O. caspius flavivirus from Portugal, encodes a polyprotein showing all the features ...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-013-0960-9
更新日期:2013-12-01 00:00:00
abstract::The nucleotide sequence of two cloned restriction fragments encompassing the granulin genes from the granuloviruses of the potato tuber moth, Phthorimaea operculella, PhopGV, and the Egyptian cotton leaf worm, Spodoptera littoralis, SpliGV, have been determined. Although both viruses are able to infect the same Ph. op...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1023/a:1008179228236
更新日期:2000-10-01 00:00:00
abstract::The varicella zoster virus (VZV) ORF4 protein, one of immediate-early genes protein, is associated with the tegument in purified virions. ORF4 protein functions at both transcriptional and post-transcriptional levels, present during different phase of whole VZV life cycle. ORF4 protein acts as a nucleocytoplasm shuttl...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-013-1006-z
更新日期:2014-04-01 00:00:00
abstract::Serum samples collected from 88 Peruvians with unexplained fever were analyzed for viral sequences using metagenomics. Nucleic acids of anelloviruses, pegivirus A (GBV-C), HIV, Dengue virus, and Oropouche virus were detected. We also characterized from two sera the RNA genomes of new species of partitivirus and dicist...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-017-1514-3
更新日期:2018-02-01 00:00:00
abstract::In our transient expression assays, the IE180 and TK promoters were markedly suppressed by the EP0 of the pseudorabies virus strains Ea and Fa (EP0/Ea, EP0/Fa). This is in contrast with the transactivating activity of EP0 from strain YS-81 (EP0/YS-81) in previous studies. Amino acid sequence alignment revealed several...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-008-0320-3
更新日期:2009-04-01 00:00:00
abstract::Novel duck reovirus (NDRV), the prototype strain of the species Avian orthoreovirus (ARV), is associated with high mortality in Pekin ducklings. σC is an outer capsid protein encoded by the S1 genome segment of NDRV which mediates attachment to host cells. Our previous studies using immunoprecipitation and mass spectr...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/s11262-020-01750-8
更新日期:2020-06-01 00:00:00
abstract::The threat of highly virulent avian influenza, such as H5N1 and swine-origin H1N1 influenza viruses, bring out an urgent need to develop a universal influenza vaccine, which may provide cross-protection against different strain of influenza A viruses. The extra-domain of influenza M2 protein (M2e), which is almost com...
journal_title:Virus genes
pub_type: 杂志文章,评审
doi:10.1007/s11262-010-0547-7
更新日期:2011-02-01 00:00:00
abstract::The complete nucleotide sequence of genome segment 4 from the human group C rotavirus (Bristol strain) was determined. Comparison of the nucleotide sequences of the genome termini with the consensus 5' and 3' terminal non-coding sequences of the human group C rotavirus genome revealed characteristic 5' and 3' sequence...
journal_title:Virus genes
pub_type: 杂志文章
doi:10.1007/BF00568909
更新日期:1996-01-01 00:00:00