The VP3 gene of human group C rotavirus.

Abstract:

:The complete nucleotide sequence of genome segment 4 from the human group C rotavirus (Bristol strain) was determined. Comparison of the nucleotide sequences of the genome termini with the consensus 5' and 3' terminal non-coding sequences of the human group C rotavirus genome revealed characteristic 5' and 3' sequence motifs. Human group C rotavirus genome segment 4 is 2,166bp long and encodes a single open reading frame of 2,082 nucleotides (693 amino acids) starting at nucleotide 55 and terminating at nucleotide 2,136 giving a 3' untranslated region of 30 nucleotides. Alignment with the porcine group C VP3 equivalent gene showed the human gene is one amino acid longer, and that the proteins have 84.1% amino acid sequence identity. A conserved potential nucleotide binding motif shared with the porcine VP3 sequence was identified. Analogy with the group A rotaviruses suggested that the genome segment 4 encodes the group C rotavirus guanylyltransferase.

journal_name

Virus Genes

journal_title

Virus genes

authors

Samarbaf-Zadeh AR,Lambden PR,Green SM,Deng Y,Caul EO,Clarke IN

doi

10.1007/BF00568909

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

169-73

issue

2

eissn

0920-8569

issn

1572-994X

journal_volume

13

pub_type

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